Patents Assigned to Nicox Ophthalmics, Inc.
  • Ophthalmic formulations of cetirizine and methods of use
    Patent number: 11918573
    Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: March 5, 2024
    Assignee: NICOX OPHTHALMICS, INC.
    Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
  • Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
    Patent number: 11814408
    Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic gent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, Meibomian gland dysfuntion or skin inflammation or a respiratory disease (e.g., asthma).
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: November 14, 2023
    Assignee: Nicox Ophthalmics, Inc.
    Inventors: Thomas Cavanagh, Shikha P. Barman, Tian Hao, Thomas B. Leland, Ritesh V. Thekkedath
  • Ophthalmic formulations of cetirizine and methods of use
    Patent number: 11617749
    Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: April 4, 2023
    Assignee: Nicox Ophthalmics, Inc.
    Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
  • Process for the preparation of sterile ophthalmic aqueous fluticasone propionate form a nanocrystals suspensions
    Patent number: 11406596
    Abstract: A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 9, 2022
    Assignee: NICOX OPHTHALMICS, INC.
    Inventors: Jean-Michel Bukowski, Akshay Nadkarni, José L. Boyer, Brigitte Duquesroix-Chakroun, Tomas Navratil
  • Ophthalmic formulations of cetirizine and methods of use
    Patent number: 10987352
    Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: April 27, 2021
    Assignee: NICOX OPHTHALMICS, INC
    Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
  • Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
    Patent number: 10954263
    Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 23, 2021
    Assignee: NICOX OPHTHALMICS, INC
    Inventors: Thomas Cavanagh, Shikha P. Barman, Tian Hao, Thomas B. Leland, Ritesh V. Thekkedath
  • Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
    Patent number: 10174071
    Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: January 8, 2019
    Assignee: NICOX OPHTHALMICS, INC.
    Inventors: Thomas Cavanagh, Shikha P. Barman, Tian Hao, Thomas B. Leland, Ritesh V. Thekkedath
  • Ophthalmic formulations of cetirizine and methods of use
    Patent number: 9993471
    Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: June 12, 2018
    Assignee: NICOX OPHTHALMICS, INC.
    Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
  • Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
    Patent number: 9822142
    Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: November 21, 2017
    Assignee: Nicox Ophthalmics, Inc.
    Inventors: Thomas Cavanagh, Shikha P. Barman, Tian Hao, Thomas B. Leland, Ritesh V. Thekkedath
  • Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
    Patent number: 9815865
    Abstract: The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: November 14, 2017
    Assignee: Nicox Ophthalmics, Inc.
    Inventors: Shikha P. Barman, Ritesh Vasudevan Thekkedath, Koushik Barman, Thomas Cavanagh, Tian Hao, Thomas Bovard Leland
  • Ophthalmic formulations of cetirizine and methods of use
    Patent number: 9750684
    Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: September 5, 2017
    Assignee: Nicox Ophthalmics, Inc.
    Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice