Abstract: The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
Type:
Grant
Filed:
September 2, 2015
Date of Patent:
October 9, 2018
Assignee:
NICOX SCIENCE IRELAND
Inventors:
Nicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Sergio Romeo
Abstract: The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan-1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.
Type:
Grant
Filed:
July 7, 2014
Date of Patent:
February 20, 2018
Assignee:
NICOX SCIENCE IRELAND
Inventors:
Ennio Ongini, Nicoletta Almirante, Laura Storoni, Elena Bastia
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
Type:
Grant
Filed:
April 14, 2014
Date of Patent:
March 21, 2017
Assignee:
Nicox Science Ireland
Inventors:
Nicoletta Almirante, Laura Storoni, Gael Ronsin, Elena Bastia
Abstract: The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
Type:
Grant
Filed:
October 10, 2013
Date of Patent:
September 20, 2016
Assignee:
NICOX SCIENCE IRELAND
Inventors:
Ennio Ongini, Nicoletta Almirante, Laura Storoni
Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metabolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
Type:
Grant
Filed:
January 22, 2014
Date of Patent:
July 14, 2015
Assignee:
NICOX SCIENCE IRELAND
Inventors:
Gael Ronsin, Laura Storoni, Francesca Benedini
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
Type:
Grant
Filed:
October 23, 2012
Date of Patent:
June 23, 2015
Assignee:
Nicox Science Ireland
Inventors:
Gael Ronsin, Laura Storoni, Francesca Benedini