Patents Assigned to Niigata University of Pharmacy and Applied Life Sciences
  • Heptamer-type small guide nucleic acids inducing apoptosis of human leukemia cells
    Patent number: 9617538
    Abstract: There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 11, 2017
    Assignees: NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCE, NIIGATA UNIVERSITY
    Inventors: Masayuki Nashimoto, Masuhiro Takahashi, Miwako Narita, Tetsuo Yoshida, Tatsuya Miyazawa
  • Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
    Patent number: 7365221
    Abstract: Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl or ester thereof; R2 is hydrogen, halogen, hydroxyl or —OR3, R3 is C2-C20 substituted or unsubstituted carboxyacyl; and R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: April 29, 2008
    Assignees: Panacos Pharmaceuticals, Inc., The University of North Carolina at Chapel Hill, Niigata University of Pharmacy and Applied Life Sciences
    Inventors: Graham P. Allaway, Carl T. Wild, Yoshiki Kashiwada, Kuo-Hsiung Lee
  • Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
    Publication number: 20050020548
    Abstract: Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl or ester thereof; R2 is hydrogen, halogen, hydroxyl or —OR3, R3 is C2-C20 substituted or unsubstituted carboxyacyl; and R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.
    Type: Application
    Filed: June 18, 2004
    Publication date: January 27, 2005
    Applicants: Panacos Pharmaceuticals, Inc., The University of North Carolina at Chapel Hill, Niigata University of Pharmacy and Applied Life Sciences
    Inventors: Graham Allaway, Carl Wild, Yoshiki Kashiwada, Kuo-Hsiung Lee