Abstract: The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.
Type:
Grant
Filed:
February 18, 2011
Date of Patent:
August 19, 2014
Assignee:
Nikinc Pharma B.V.
Inventors:
Suzette Veronica Van Der Waal, Stanley Brul, Johannes Jacob De Soet, Lucas Wilhelmus Maria Van Der Sluis
Abstract: The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.
Type:
Application
Filed:
February 18, 2011
Publication date:
December 27, 2012
Applicant:
Nikinc Pharma B.V.
Inventors:
Suzette Veronica Van Der Waal, Stanley Brul, Johannes Jacob De Soet, Lucas Wilhelmus Maria Van Der Sluis