Abstract: A syringe in accordance with the invention comprises a cylinder (10) having a smooth, substantially hemi-spherical ‘closed’ end (12) with a centrally placed hole (14) for dispensing the contents of the syringe. The plunger may have an annular rim (22) close to its inner end, which is arranged to engage with a corresponding annular slot (28) formed in the inner wall of the cylinder when the syringe is in its filled state. The rim (22) not only holds the plunger 16 in position prior to use, but also acts to prevent leakage of the contents. As the plunger (16) is depressed the rim (22) also acts to provide a tight seal between the piston and the cylinder. The cylinder has a second internal slot or groove (30) close to its domed end (12). When the plunger reaches the end of its travel the rim (22) engages tightly with the second annular slot (30) in order to prevent the piston being pulled out again for re-use of the syringe.