Patents Assigned to Nippon Hypox Laboratories Incorporated
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Publication number: 20180049996Abstract: A novel agent which is effective in the prevention or treatment of a chronic respiratory disease such as COPD, interstitial pneumonia and asthma is provided. The therapeutic agent for a chronic respiratory disease comprises, as an active ingredient, a hydroquinone derivative represented by general formula (1) wherein R1 represents an alkyl group having 4 to 8 carbon atoms, and R2 represents a hydrogen atom, an alkylcarbonyl group having 2 to 6 carbon atoms or an alkoxycarbonyl group having 2 to 6 carbon atoms.Type: ApplicationFiled: October 19, 2017Publication date: February 22, 2018Applicant: NIPPON HYPOX LABORATORIES INCORPORATEDInventors: Tokutaro Miki, Hiroshi Nishikawa, Jong-Koo Kang, Satoru Sugiyama
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Patent number: 7847132Abstract: The progression of hepatic fibrosis and hepatic cirrhosis caused by various hepatic disorders and damages such as chronic hepatitis can be restrained by hepatic fibrosis inhibitor containing a compound represented by the following chemical formula: wherein, R1 represents an alkyl group with a carbon number of 4 to 8, and R2 represents a hydrogen atom, alkylcarbonyl group with a carbon number of 2 to 6, or alkoxycarbonyl group with a carbon number of 2 to 6.Type: GrantFiled: December 7, 2009Date of Patent: December 7, 2010Assignee: Nippon Hypox Laboratories IncorporatedInventors: Naohisa Ishikawa, Satoru Sugiyama, Tokutaro Miki, Hiroshi Nishikawa
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Patent number: 5416242Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.Type: GrantFiled: August 1, 1994Date of Patent: May 16, 1995Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro
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Patent number: 5276058Abstract: Novel 3,4-dihydroxychalcone derivatives useful as a pharmaceutical material, and novel anti-inflammatory preparations. The 3,4-dihydroxychalcone derivatives are compounds of the formula [I], ##STR1## wherein X is a substituted phenyl group represented, e.g., by the formula (i), ##STR2## in which R.sup.1 is a hydrogen atom or an alkyl group and R.sup.2 is an alkyl group, an alkoxy group or an --OH group (excluding an OH-group in the 4-position)or salts thereof. The anti-inflammatory preparations contain one of the above 3,4-dihydroxychalcone derivatives as an active ingredient.Type: GrantFiled: June 9, 1993Date of Patent: January 4, 1994Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro
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Patent number: 5264421Abstract: A food composition prepared from a lactic acid fermented aqueous liquorice extract which is free of the disadvantages of extremely strong sweetness which makes liquorice extracts unsuitable for maintaining and enhancing the pharmacological activities (both disease preventing and treating effects) of treating ulcers and hepatic diseases.Type: GrantFiled: April 6, 1992Date of Patent: November 23, 1993Assignee: Nippon Hypox Laboratories, IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro, Hisao Kakegawa, Tokutaro Miki
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Patent number: 5194445Abstract: The preparation for preventing and curing organ dysfunctions, provided by the present invention, is a medicament having the activity to prevent and cure organ dysfunctions which active oxygen species and active organic radical species would cause, and unconventionally improved in stability in vivo by containing, as an active component, the ascorbic acid derivative of the formula, ##STR1## wherein R.sub.2 is a group selected from the class consisting of an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms, an alkyl group having 9 inclusive to 17 inclusive alkyl groups and an alkoxycarbonyl lower alkyl group of which the terminal alkoxy group has 7 inclusive to 20 inclusive carbon atoms; and the ascorbic acid derivative of the above formula in which R.sub.Type: GrantFiled: May 20, 1991Date of Patent: March 16, 1993Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5143648Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: August 20, 1991Date of Patent: September 1, 1992Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5141547Abstract: A process for the production of a molded glass article is disclosed, said process comprises the steps of: applying wet treatment to a surface of a lead oxide-containing glass material, thereby forming a hydrated layer having a lower lead oxide content than that of a basic glass; heating the glass material having the hydrated layer; and press-molding the heated glass material. According to the process, a molded glass article having no cloudiness can be obtained and lead is not deposited on the surfaces of the molds used.Type: GrantFiled: February 20, 1991Date of Patent: August 25, 1992Assignee: Nippon Hypox Laboratories IncorporatedInventors: Shigeru Asanuma, Shoji Adachi, Yasuhiko Kaneko
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Patent number: 5109025Abstract: 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.Type: GrantFiled: July 25, 1990Date of Patent: April 28, 1992Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: 5061812Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: July 20, 1989Date of Patent: October 29, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5053490Abstract: A powdery complex is obtained by combining a useful substance such as vitamin E and liquid fatty oil with albumin. This powdery complex has excellent storage stability and can keep the useful substance contained therein stably for a long time.Type: GrantFiled: March 13, 1989Date of Patent: October 1, 1991Assignees: Nippon Hypox Laboratories Incorporated, Toshio SatohInventors: Toshio Satoh, Hitoshi Matsumoto, Kakegawa Hisao
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Patent number: 5051406Abstract: The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.Type: GrantFiled: November 30, 1990Date of Patent: September 24, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventor: Toshio Satoh
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Patent number: 5034543Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: July 20, 1989Date of Patent: July 23, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5004742Abstract: The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.Type: GrantFiled: August 14, 1989Date of Patent: April 2, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 4952564Abstract: The present invention which is an antiallergic agent characterized by containing isoliquiritigenin as an effective component provides a novel antiallergic agent exhibiting a low toxicity and excellent antiallergic properties.Type: GrantFiled: September 23, 1987Date of Patent: August 28, 1990Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Sato, Hitoshi Matsumoto
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Patent number: 4898890Abstract: A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.Type: GrantFiled: December 23, 1987Date of Patent: February 6, 1990Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Sato, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: RE36139Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carton atoms, and/or a salt thereof.Type: GrantFiled: December 13, 1995Date of Patent: March 9, 1999Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro