Patents Assigned to Nippon Hypox Laboratories Incorporated
  • Publication number: 20180049996
    Abstract: A novel agent which is effective in the prevention or treatment of a chronic respiratory disease such as COPD, interstitial pneumonia and asthma is provided. The therapeutic agent for a chronic respiratory disease comprises, as an active ingredient, a hydroquinone derivative represented by general formula (1) wherein R1 represents an alkyl group having 4 to 8 carbon atoms, and R2 represents a hydrogen atom, an alkylcarbonyl group having 2 to 6 carbon atoms or an alkoxycarbonyl group having 2 to 6 carbon atoms.
    Type: Application
    Filed: October 19, 2017
    Publication date: February 22, 2018
    Applicant: NIPPON HYPOX LABORATORIES INCORPORATED
    Inventors: Tokutaro Miki, Hiroshi Nishikawa, Jong-Koo Kang, Satoru Sugiyama
  • Patent number: 7847132
    Abstract: The progression of hepatic fibrosis and hepatic cirrhosis caused by various hepatic disorders and damages such as chronic hepatitis can be restrained by hepatic fibrosis inhibitor containing a compound represented by the following chemical formula: wherein, R1 represents an alkyl group with a carbon number of 4 to 8, and R2 represents a hydrogen atom, alkylcarbonyl group with a carbon number of 2 to 6, or alkoxycarbonyl group with a carbon number of 2 to 6.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: December 7, 2010
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Naohisa Ishikawa, Satoru Sugiyama, Tokutaro Miki, Hiroshi Nishikawa
  • Patent number: 5416242
    Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: May 16, 1995
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro
  • Patent number: 5276058
    Abstract: Novel 3,4-dihydroxychalcone derivatives useful as a pharmaceutical material, and novel anti-inflammatory preparations. The 3,4-dihydroxychalcone derivatives are compounds of the formula [I], ##STR1## wherein X is a substituted phenyl group represented, e.g., by the formula (i), ##STR2## in which R.sup.1 is a hydrogen atom or an alkyl group and R.sup.2 is an alkyl group, an alkoxy group or an --OH group (excluding an OH-group in the 4-position)or salts thereof. The anti-inflammatory preparations contain one of the above 3,4-dihydroxychalcone derivatives as an active ingredient.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: January 4, 1994
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro
  • Patent number: 5264421
    Abstract: A food composition prepared from a lactic acid fermented aqueous liquorice extract which is free of the disadvantages of extremely strong sweetness which makes liquorice extracts unsuitable for maintaining and enhancing the pharmacological activities (both disease preventing and treating effects) of treating ulcers and hepatic diseases.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: November 23, 1993
    Assignee: Nippon Hypox Laboratories, Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro, Hisao Kakegawa, Tokutaro Miki
  • Patent number: 5194445
    Abstract: The preparation for preventing and curing organ dysfunctions, provided by the present invention, is a medicament having the activity to prevent and cure organ dysfunctions which active oxygen species and active organic radical species would cause, and unconventionally improved in stability in vivo by containing, as an active component, the ascorbic acid derivative of the formula, ##STR1## wherein R.sub.2 is a group selected from the class consisting of an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms, an alkyl group having 9 inclusive to 17 inclusive alkyl groups and an alkoxycarbonyl lower alkyl group of which the terminal alkoxy group has 7 inclusive to 20 inclusive carbon atoms; and the ascorbic acid derivative of the above formula in which R.sub.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: March 16, 1993
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 5143648
    Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: September 1, 1992
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 5141547
    Abstract: A process for the production of a molded glass article is disclosed, said process comprises the steps of: applying wet treatment to a surface of a lead oxide-containing glass material, thereby forming a hydrated layer having a lower lead oxide content than that of a basic glass; heating the glass material having the hydrated layer; and press-molding the heated glass material. According to the process, a molded glass article having no cloudiness can be obtained and lead is not deposited on the surfaces of the molds used.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: August 25, 1992
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Shigeru Asanuma, Shoji Adachi, Yasuhiko Kaneko
  • Patent number: 5109025
    Abstract: 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: April 28, 1992
    Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa
  • Patent number: 5061812
    Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: October 29, 1991
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 5053490
    Abstract: A powdery complex is obtained by combining a useful substance such as vitamin E and liquid fatty oil with albumin. This powdery complex has excellent storage stability and can keep the useful substance contained therein stably for a long time.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: October 1, 1991
    Assignees: Nippon Hypox Laboratories Incorporated, Toshio Satoh
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Kakegawa Hisao
  • Patent number: 5051406
    Abstract: The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: September 24, 1991
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventor: Toshio Satoh
  • Patent number: 5034543
    Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: July 23, 1991
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 5004742
    Abstract: The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.
    Type: Grant
    Filed: August 14, 1989
    Date of Patent: April 2, 1991
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 4952564
    Abstract: The present invention which is an antiallergic agent characterized by containing isoliquiritigenin as an effective component provides a novel antiallergic agent exhibiting a low toxicity and excellent antiallergic properties.
    Type: Grant
    Filed: September 23, 1987
    Date of Patent: August 28, 1990
    Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Sato, Hitoshi Matsumoto
  • Patent number: 4898890
    Abstract: A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: February 6, 1990
    Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Sato, Hitoshi Matsumoto, Hisao Kakegawa
  • Patent number: RE36139
    Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carton atoms, and/or a salt thereof.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: March 9, 1999
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro