Patents Assigned to Nippon Kayaku Kabushiki
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Publication number: 20180214423Abstract: It is an object of the present invention to provide a pharmaceutical composition which can suppress a reduction in the content of an active ingredient caused by oxidation or decomposition of the rapamycin or a derivative thereof, can ensure long-term stability, and has high safety. The present invention provides a pharmaceutical composition comprising (A) rapamycin or a derivative thereof and (B) trehalose, and a method for producing a pharmaceutical composition comprising rapamycin or a derivative thereof, which comprises adding a solution containing rapamycin or a derivative thereof to sugars having a critical relative humidity at 25° C. of 95% or more.Type: ApplicationFiled: July 27, 2016Publication date: August 2, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventor: Dai KAWAMURA
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Publication number: 20180208685Abstract: A supported molded catalyst having increased hardness, the supported molded catalyst being capable of improving the long-term stability of a reaction for producing a conjugated diolefin by catalytic oxidative dehydrogenation from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen; and a method for producing the catalyst is provided. A molded catalyst for conjugated diolefin production, the molded catalyst being a catalyst for producing a conjugated diolefin by a catalytic oxidative dehydrogenation reaction from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen, and being produced by molding a composite metal oxide and a glass fiber-like inorganic auxiliary agent.Type: ApplicationFiled: September 15, 2016Publication date: July 26, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Shigeki OKUMURA, Yuta NAKAZAWA, Hiroki MOTOMURA, Bungo NISHIZAWA, Tomohiro OBATA, Koji NAKAYAMA
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Patent number: 10017653Abstract: An aqueous pigment ink composition having high scratch resistance and good ejection properties and redispersibility, an ink jet recording method using the aqueous pigment ink composition, and a colored substance including the aqueous pigment ink composition. The ink composition includes a colorant, a resin, and water. The colorant includes a coloring matter that is substantially insoluble in water. The resin is a polymer produced by polymerization of at least one monomer represented by the following formula (1) in which R1 denotes a hydrogen atom or a methyl group, and R2 denotes a methyl group, a C8 alkyl group, or the like.Type: GrantFiled: March 26, 2015Date of Patent: July 10, 2018Assignee: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Akira Kawaguchi, Maiko Iuchi, Ha Sai, Toru Ishii
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Publication number: 20180186712Abstract: Provided is a method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid, which enables one to achieve an operation stably over a long period of time while improving an effective yield, even in a high-load reaction, and in the method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid, multilayer filling of stacking two or more catalyst layers each containing a complex metal oxide catalyst in the axial direction of the tube under specified conditions is performed, and the catalyst layer on the most gas outlet side in the tube axis contains a catalyst containing a compound represented by a specified formulation formula.Type: ApplicationFiled: May 12, 2016Publication date: July 5, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Motohiko SUGIYAMA, Ryota HIRAOKA, Tomoyuki KAWAMURA, Shogo YASUDA
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Patent number: 10012901Abstract: The purpose of the present invention is to provide the following: a photosensitive epoxy resin composition that, via photolithography, can form a high-resolution, low-stress image that has vertical side walls and resists moisture and heat, and/or a resist laminate using said photosensitive epoxy resin composition; and an article or articles obtained by curing said photosensitive epoxy resin composition and/or resist laminate. The present invention is a photosensitive resin composition containing the following: an epoxy resin (A), a polyol compound (B) having a specific structure, a cationic-polymerization photoinitiator (C), a silane compound (D) containing an epoxy group, and a reactive epoxy monomer (E) having a specific structure. The epoxy resin (A) contains the phenol derivative represented by formula (1), an epoxy resin (a) obtained via a reaction with epihalohydrin, and an epoxy resin (b) that can be represented by formula (2).Type: GrantFiled: November 21, 2013Date of Patent: July 3, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Naoko Imaizumi, Shinya Inagaki, Nao Honda
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Patent number: 10007142Abstract: A polarizer contains, in a base thereof, at least one of an azo compound represented by Formula (1) or a salt thereof (as compound A), and at least one of an azo compound represented by Formula (2-I), (2-II), (3), (4-I), (4-II), (5-I) or (5-II), or a salt thereof (as compound B).Type: GrantFiled: November 16, 2017Date of Patent: June 26, 2018Assignees: NIPPON KAYAKU KABUSHIKI KAISHA, POLATECHNO CO., LTD.Inventors: Noriaki Mochizuki, Takahiro Higeta
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Patent number: 9993569Abstract: Provided is a pharmaceutical preparation composition comprising a polymerized camptothecin derivative which is obtained by bonding a camptothecin derivative to a polymer carrier, and has nanoparticle-forming properties of associating in an aqueous solution, the pharmaceutical preparation composition having enhanced preparation stability. Particularly, a pharmaceutical preparation maintaining nanoparticle-forming properties, which are an important factor, and having an excellent storage stability is provided. Disclosed is a pharmaceutical preparation comprising a block copolymer in which a polyethylene glycol segment is linked to a polyglutamic acid segment containing a glutamic acid unit having a camptothecin derivative bonded thereto, the pharmaceutical preparation capable of forming associates in an aqueous solution. When the pharmaceutical preparation is made into an aqueous solution containing the camptothecin derivative at a concentration of 1 mg/mL, the pH of the aqueous solution is 2.4 to 7.Type: GrantFiled: November 27, 2017Date of Patent: June 12, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Shinya Fujita, Shin Aoki
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Publication number: 20180154859Abstract: A gas generator includes a partition portion, a cylindrical portion, and a separation wall portion which divide a space in a housing into a first combustion chamber, a second combustion chamber, a gas passage chamber, and a gas emission chamber. The first combustion chamber includes a space inside the cylindrical portion on a side of an igniter relative to the separation wall portion, and the second combustion chamber includes the space inside the cylindrical portion on a side of the partition portion relative to the separation wall portion. The gas passage chamber includes a space outside the cylindrical portion which faces a circumferential wall portion of the housing, and the gas emission chamber includes a space on a side of a gas discharge opening relative to the partition portion.Type: ApplicationFiled: August 20, 2015Publication date: June 7, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Dairi KUBO, Daisuke HAGIHARA
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Patent number: 9963542Abstract: A silicone-modified epoxy resin which yields a cured product having low gas permeability and excellent strength; a composition of the silicone-modified epoxy resin; and an epoxy resin cured product obtainable by curing the composition, are provided. An epoxy resin represented by the following Formula (1): wherein R1 represents a hydrocarbon group having 1 to 6 carbon atoms; X represents an organic group having a norbornane epoxy structure, or a hydrocarbon group having 1 to 6 carbon atoms; n represents an integer from 1 to 3; plural R1s and plural Xs present in the formula may be respectively identical or different; and two or more of plural Xs represent an organic group having a norbornane epoxy structure.Type: GrantFiled: March 25, 2015Date of Patent: May 8, 2018Assignees: Shin-Etsu Chemical Co., Ltd., Nippon Kayaku Kabushiki KaishaInventors: Toshio Shiobara, Junichi Sawada, Miyuki Wakao, Tsutomu Kashiwagi, Naofusa Miyagawa, Yoshihiro Kawada, Chie Sasaki, Naosuke Taniguchi
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Patent number: 9944760Abstract: The purpose of the present invention is to provide a silicone-modified epoxy resin which produces a cured product having excellent low gas permeability and strength; a composition of the resin; and an epoxy resin cured product obtainable by curing the composition. Disclosed is an epoxy resin represented by the following Formula (1): wherein R1 independently represents a monovalent aromatic hydrocarbon group having 6 to 12 carbon atoms; R2 independently represents a monovalent aliphatic hydrocarbon group having 1 to 12 carbon atoms; R3 independently represents a monovalent aliphatic hydrocarbon group having 1 to 12 carbon atoms or a monovalent aromatic hydrocarbon group having 6 to 12 carbon atoms; R4 represents an oxygen atom or a divalent hydrocarbon group having an aliphatic cyclic structure; R5 represents silicone chain having a norbornane epoxy structure at either end; and X represents an organic group having a norbornane epoxy group.Type: GrantFiled: February 18, 2015Date of Patent: April 17, 2018Assignees: Shin-Etsu Chemical Co., Ltd., Nippon Kayaku Kabushiki KaishaInventors: Toshio Shiobara, Junichi Sawada, Miyuki Wakao, Tsutomu Kashiwagi, Naofusa Miyagawa, Yoshihiro Kawada, Chie Sasaki, Naosuke Taniguchi
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Publication number: 20180071721Abstract: Provided are a catalyst that may suppress the production of a coke-like substance in a reaction for producing a conjugated diolefin from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen. A composite metal oxide catalyst for producing a conjugated diolefin from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen by a catalytic oxidative dehydrogenation reaction, the composite metal oxide catalyst having a relative intensity range of X-ray diffraction peaks represented by the following Formula (A): 0?Rh(=Ph1/Ph2)<0.8 (A) wherein Ph1 represents the maximum peak height within the range of 2?=28.1°±0.2° for the X-ray diffraction peaks; Ph2 represents the maximum peak height within the range of 2?=27.9°±0.2° for the X-ray diffraction peaks; and Rh represents the relative intensity ratio of Ph1 with respect to Ph2.Type: ApplicationFiled: March 2, 2016Publication date: March 15, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Shigeki OKUMURA, Yuuta NAKAZAWA, Hiroki MOTOMURA, Bungo NISHIZAWA, Koji NAKAYAMA
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Patent number: 9902364Abstract: A gas generator includes a housing and a partition portion dividing a space in the housing into a combustion chamber accommodating a gas generating agent and a filter chamber accommodating a filter. The partition portion includes a first region which opens at the time of activation by being located to be opposed to a hollow portion of the filter and an annular second region which does not open even at the time of activation by being located to be opposed to a portion of an axial end surface of the filter except for the hollow portion. The second region is provided with a large-thickness portion constructed to be greater in thickness than the first region and opposed to an outer edge portion of the axial end surface of the filter, and the large-thickness portion is constructed to gradually be greater in thickness from an inner circumferential end portion toward an outer circumferential end portion.Type: GrantFiled: July 23, 2015Date of Patent: February 27, 2018Assignee: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Takahiro Imai, Dairi Kubo
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Publication number: 20180029018Abstract: Provided is a catalyst for manufacturing an unsaturated aldehyde and/or an unsaturated carboxylic acid, which is prepared by a method in which a molybdenum component raw material is composed of only an ammonium molybdate, the weight of water for dissolution is 8.5 times or less relative to the weight of molybdenum contained in the ammonium molybdate; and a bismuth component raw material is composed of only bismuth nitrate, the weight of a nitric acid aqueous solution for dissolution is 2.3 times or more relative to the weight of bismuth contained in the bismuth nitrate, and a nitric acid concentration in the nitric acid aqueous solution for dissolving the bismuth nitrate is 10% by weight or more.Type: ApplicationFiled: February 25, 2016Publication date: February 1, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Tomoyuki KAWAMURA, Motohiko SUGIYAMA, Ryota HIRAOKA
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Publication number: 20180029019Abstract: Provided are a catalyst which, in a reaction. for producing a conjugated diolefin by catalytic oxidative dehydrogenation from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen, may suppress the production of a coke-like substance and improve the long-term stability of the reaction; and a method for producing the same. Disclosed is a composite metal oxide catalyst for producing a conjugated diolefin by a gas phase catalytic oxidative dehydrogenation reaction from a mixed gas including a monoolefin having 4 or more carbon atoms and molecular oxygen, the composite metal oxide catalyst having a solid acidity of 35 to 172 ?mol/g.Type: ApplicationFiled: March 2, 2016Publication date: February 1, 2018Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Yuuta NAKAZAWA, Shigeki OKUMURA, Hiroki MOTOMURA, Bungo NISHIZAWA, Koji NAKAYAMA
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Patent number: 9855261Abstract: The purpose of the present invention is to provide a polymeric compound in which a camptothecin compound and an anti-cancer effect enhancer, particularly a PARP inhibitor, are bound to a single molecule, whereby it becomes possible to reduce the toxicity to normal cells and deliver and release the two components to an affected area with high efficiency to thereby improve the pharmacological efficacy of the two components. Provided is a polymeric compound represented by general formula (1).Type: GrantFiled: October 31, 2013Date of Patent: January 2, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Keiichiro Yamamoto, Manami Okazaki
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Patent number: 9855339Abstract: Provided is a pharmaceutical preparation composition comprising a polymerized camptothecin derivative which is obtained by bonding a camptothecin derivative to a polymer carrier, and has nanoparticle-forming properties of associating in an aqueous solution, the pharmaceutical preparation composition having enhanced preparation stability. Particularly, a pharmaceutical preparation maintaining nanoparticle-forming properties, which are an important factor, and having an excellent storage stability is provided. Disclosed is a pharmaceutical preparation comprising a block copolymer in which a polyethylene glycol segment is linked to a polyglutamic acid segment containing a glutamic acid unit having a camptothecin derivative bonded thereto, the pharmaceutical preparation capable of forming associates in an aqueous solution. When the pharmaceutical preparation is made into an aqueous solution containing the camptothecin derivative at a concentration of 1 mg/mL, the pH of the aqueous solution is 2.4 to 7.Type: GrantFiled: October 16, 2015Date of Patent: January 2, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Shinya Fujita, Shin Aoki
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Patent number: 9859508Abstract: [Problem] To provide: a novel compound which has high mobility and on/off ratio and is useful for organic electronic devices; and a method for producing the compound. [Solution] A condensed polycyclic aromatic compound which is represented by general formula (1). (In the formula, A represents a 1,5-dihydronaphthalene ring or a 2,6-dihydronaphthalene ring; each of R1, R2, R3 and R4 independently represents a hydrogen atom, a halogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted alicyclic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted hydrocarbon oxy group, a substituted or unsubstituted ester group, a substituted or unsubstituted acyl group, or a substituted or unsubstituted cyano group; and each of X1 and X2 independently represents an oxygen atom, a sulfur atom or a selenium atom.Type: GrantFiled: February 27, 2014Date of Patent: January 2, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kazuo Takimiya, Shoji Shinamura, Masahiro Hamada, Yuichi Sadamitsu
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Patent number: 9857685Abstract: The purpose of the present invention is to provide: a resin composition, a cured product of which has extremely low residual stress and exhibits excellent adhesion to a metal substrate such as a Pt, LT or Ta substrate after a wet heat test in the fields of semiconductors and MEMS/micromachine applications; a laminate of this resin composition; and a cured product of this resin composition or the laminate. The present invention is a photosensitive resin composition which contains an epoxy resin (A), a compound having a phenolic hydroxyl group (B) and a cationic photopolymerization initiator (C), and wherein: the epoxy resin (A) has a weighted average epoxy equivalent weight of 300 g/eq. or more; 20% by mass or more of the epoxy resin (A) is an epoxy resin represented by formula (1) and having an epoxy equivalent weight of 500-4,500 g/eq.; and the compound having a phenolic hydroxyl group (B) contains a phenolic compound having a specific structure.Type: GrantFiled: June 9, 2015Date of Patent: January 2, 2018Assignee: Nippon Kayaku Kabushiki KaishaInventors: Naoko Imaizumi, Yoshiyuki Ono, Takanori Koizumi, Maki Kumagai, Shinya Inagaki
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Publication number: 20170350856Abstract: A field effect transistor and a sensor using the field effect transistor is provided. The field effect transistor can be manufactured so as to have uniform properties by simple steps at low costs, and can stably detect, when used as a sensor, a very small amount of analyte with a high sensitivity while the properties are hardly deteriorated. A channel of the field effect transistor is constituted by a single-walled carbon nanotube thin film that is grown, by a chemical vapor deposition method, using particles of a nonmetallic material as growth nuclei, the nonmetallic material containing 500 mass ppm or less metallic impurities that contain a metal and its compounds.Type: ApplicationFiled: August 6, 2015Publication date: December 7, 2017Applicants: NIPPON KAYAKU KABUSHIKI KAISHA, OSAKA UNIVERSITYInventors: Yoshihiro KOBAYASHI, Ryota NEGISHI, Hiroto KASE, Michiharu ARIFUKU, Noriko KIYOYANAGI, Tomio MORINO
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Publication number: 20170306092Abstract: Problem to be Solved One of the objects of the resent invention is to provide a new polybenzoxazine compound that can afford a cured product having excellent toughness, heat resistance and flame retardance without using other components together. Solution A benzoxazine compound represented by formula (1): wherein n is an average repeating number and represents a real number of 1 to 5; R1 to R8 each independently represent a hydrogen atom, a halogen atom, an alkyl group having a carbon number of 1 to 8 or an aryl group; when n is 2 or more and the number of each R3 to R7 is 2 or more, each R3 to R7 may be the same or different; and R9 represents a residue of a monoamine compound from which an amino group is removed.Type: ApplicationFiled: March 22, 2017Publication date: October 26, 2017Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Tsutomu TAKEICHI, Tsubasa OHSAWA, Takuto MORI, Kazunori ISHIKAWA, Koju IWASAKI