Patents Assigned to Nippon Medical School Foundation
  • Publication number: 20220235375
    Abstract: A method for producing a nucleic acid-encapsulated adeno-associated virus (AAV) hollow particle, comprising the following steps: (1) preparing a linear nucleic acid fragment comprising a sequence for A region and a sequence for D? region in an AAV inverted terminal repeat (ITR) (i.e., an AD sequence) or a sequence complementary to the AD sequence and a target gene sequence; (2) introducing the nucleic acid fragment prepared in step (1) into a cell capable of producing an AAV hollow particle; and (3) culturing the cell obtained in step (2).
    Type: Application
    Filed: July 2, 2020
    Publication date: July 28, 2022
    Applicants: NIPPON MEDICAL SCHOOL FOUNDATION, TAKARA BIO INC.
    Inventors: Takashi OKADA, Junichi MINENO, Hideto CHONO
  • Publication number: 20220127606
    Abstract: Provided are a complex that comprises a nucleic acid-containing nanoparticle and a hollow particle of a non-enveloped virus, a method for producing the complex, and a pharmaceutical composition comprising the complex.
    Type: Application
    Filed: January 29, 2020
    Publication date: April 28, 2022
    Applicants: NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Takashi Okada, Hiromi KINOH, Yoshitsugu AOKI, Shin'ichi TAKEDA
  • Publication number: 20210246173
    Abstract: The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the amino acid sequence for wild-type AAV capsid protein; a nucleic acid encoding the mutant; a cell containing the nucleic acid; a method for producing a recombinant AAV particle, comprising a step of culturing the cell to produce the recombinant AAV particle; a recombinant AAV particle containing the mutant; a composition containing the recombinant AAV particle; and a method for transferring a gene into a target cell, comprising a step of bringing the recombinant AAV particle into contact with the target cell.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 12, 2021
    Applicants: NIPPON MEDICAL SCHOOL FOUNDATION, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, TAKARA BIO INC.
    Inventors: Takashi OKADA, Hironori OKADA, Hiromi KINOH, Tatsuji ENOKI, Toshikazu NISHIE, Junichi MINENO
  • Publication number: 20210228205
    Abstract: An automatic needle mover (1) for moving a medical threaded needle includes: two shafts (a first shaft (11) and a second shaft (12)) extending in the same direction and slidable relative to each other along a longitudinal direction; a needle holding portion (a second needle support portion (22)) provided on one end side of the second shaft (12); a needle-receiving portion (a first needle support portion (21)) provided on one end side of the first shaft (11); and a handle (30) serving as a control portion for controlling the sliding of the two shafts. The needle holding portion has a first groove portion provided in a first claw portion protruding in a direction intersecting the longitudinal direction of the shafts. The needle-receiving portion has a second groove portion provided in a second claw portion protruding in a direction intersecting the longitudinal direction of the shafts.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 29, 2021
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Ryu NAKADATE, Susumu OGURI, Makoto HASHIZUME, Akio MORITA
  • Publication number: 20210205285
    Abstract: The present invention provides a therapeutic agent or a prophylactic agent of dementia containing xanthine oxidase inhibitor such as a compound represented in formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: February 17, 2017
    Publication date: July 8, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, Nippon Medical School Foundation, Teijin Phama Limited
    Inventors: Takeshi NISHINO, Shinsuke KATO, Masako KATO, Hidenori SUZUKI, Ken OKAMOTO
  • Patent number: 11028131
    Abstract: The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the amino acid sequence for wild-type AAV capsid protein; a nucleic acid encoding the mutant; a cell containing the nucleic acid; a method for producing a recombinant AAV particle, comprising a step of culturing the cell to produce the recombinant AAV particle; a recombinant AAV particle containing the mutant; a composition containing the recombinant AAV particle; and a method for transferring a gene into a target cell, comprising a step of bringing the recombinant AAV particle into contact with the target cell.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 8, 2021
    Assignees: NIPPON MEDICAL SCHOOL FOUNDATION, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, TAKARA BIO INC.
    Inventors: Takashi Okada, Hironori Okada, Hiromi Kinoh, Tatsuji Enoki, Toshikazu Nishie, Junichi Mineno
  • Publication number: 20210087560
    Abstract: An object of the present invention is to provide a vector capable of oligodendrocyte-specifically suppressing expression of the PLP1 gene for treating PMD caused by abnormality of the PLP1 gene, and a promoter and miRNA therefor, and a pharmaceutical composition comprising the vector. The oligodendrocyte-specific promoter of the present invention comprises a nucleic acid having a sequence identity of at least 90% to a nucleotide sequence set forth in SEQ ID NO: 1. The miRNA of the present invention specific to the PLP1 gene comprises a pair of nucleotide sequences consisting of a specific antisense sequence and sense sequence.
    Type: Application
    Filed: February 6, 2019
    Publication date: March 25, 2021
    Applicants: NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, NIPPON MEDICAL SCHOOL FOUNDATION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken Inoue, Heng Li, Takashi Okada, Yu Ohki, Makoto Koizumi
  • Publication number: 20200284792
    Abstract: The present invention aims to develop a method capable of evaluating T cell immune function. A method for evaluating T cell immune function including detecting and quantifying soluble PD-L1 having a binding ability to PD-1, and an ELISA system used for detecting and quantifying bsPD-L1, including a carrier with a solid-phased PD-1 protein, a means for reacting the carrier and a test sample, and a means for detecting and m quantifying soluble PD-L1 bound to the carrier as bsPD-L1.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 10, 2020
    Applicants: UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, JAPAN, NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Yoshiko IWAI, Masahiro TAKEUCHI, Tomomitsu DOI
  • Publication number: 20200002384
    Abstract: The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the amino acid sequence for wild-type AAV capsid protein; a nucleic acid encoding the mutant; a cell containing the nucleic acid; a method for producing a recombinant AAV particle, comprising a step of culturing the cell to produce the recombinant AAV particle; a recombinant AAV particle containing the mutant; a composition containing the recombinant AAV particle; and a method for transferring a gene into a target cell, comprising a step of bringing the recombinant AAV particle into contact with the target cell.
    Type: Application
    Filed: January 29, 2018
    Publication date: January 2, 2020
    Applicants: NIPPON MEDICAL SCHOOL FOUNDATION, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, TAKARA BIO INC.
    Inventors: Takashi OKADA, Hironori OKADA, Hiromi KINOH, Tatsuji ENOKI, Toshikazu NISHIE, Junichi MINENO
  • Publication number: 20190330705
    Abstract: A method of detecting somatic mutations of tumor marker genes includes recovering a peripheral blood mononuclear cell layer from a blood sample collected from a subject and examining whether or not a nucleic acid derived from tumor marker genes having somatic mutations is detected from DNA included in the peripheral blood mononuclear cell layer.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Applicants: TOPPAN PRINTING CO., LTD., NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Shiro KITANO, Takeshi Yamada, Goro Takahashi, Takuma Iwai, Koki Takeda
  • Publication number: 20190307761
    Abstract: The inventors found that postsurgical recurrence and/or metastasis of cancer is suppressed by administering a beta-blocker to a cancer patient during a perioperative period of cancer surgery. Accordingly, the disclosure provides an agent for suppressing recurrence and/or metastasis of cancer, comprising a beta-blocker and being administered during a perioperative period of cancer surgery.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 10, 2019
    Applicants: ONO PHARMACEUTICAL CO., LTD., NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Atsuhiro SAKAMOTO, Tatsuaki OKAMURA, Tomohiro HARADA
  • Patent number: 10413546
    Abstract: A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: September 17, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NIPPON MEDICAL SCHOOL FOUNDATION, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Takeshi Nishino, Shinsuke Kato, Masako Kato, Hidenori Suzuki, Ken Okamoto
  • Publication number: 20180135138
    Abstract: A method for evaluating a health condition, includes: measuring a test amount of cell free DNA per unit amount of a body fluid sample collected from a subject after tumor resection; and comparing the measured test amount of cell free DNA with a reference value so as to evaluate a health condition of the subject. The reference value is one of a predetermined threshold value; an amount of cell free DNA per unit amount of a body fluid sample collected from the subject before tumor resection; an amount of cell free DNA per unit amount of a body fluid sample collected from the subject between 1 week and 3 months after tumor resection; and an amount of cell free DNA per unit amount of a body fluid sample collected from the subject by the time of collecting the body fluid sample for measuring the test amount of cell free DNA.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicants: TOPPAN PRINTING CO., LTD., NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Shiro Kitano, Takeshi Yamada, Takuma Iwai
  • Publication number: 20180117047
    Abstract: A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.
    Type: Application
    Filed: February 23, 2016
    Publication date: May 3, 2018
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NIPPON MEDICAL SCHOOL FOUNDATION, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Takeshi NISHINO, Shinsuke KATO, Masako KATO, Hidenori SUZUKI, Ken OKAMOTO
  • Patent number: 9133484
    Abstract: A transfection agent is provided that has lower toxicity and can be applied in the clinical setting. The transfection agent comprises a peptide surfactant.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: September 15, 2015
    Assignees: 3-D MATRIX, LTD., NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Daizo Yoshida, Jiro Takei
  • Patent number: 9097693
    Abstract: The invention provides a method for simple, rapid and inexpensive analysis of drugs such as nicotine and other drugs which are accumulated in biological samples of addictive drugger of tobacco, stimulant drug and the like. The method comprises the steps of introducing the biological sample into an injection needle, inserting the needle into an injector of a chromatograph and injecting a carrier into the needle to conduct chromatography treatment.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 4, 2015
    Assignees: SHINWA CHEMICAL INDUSTRIES, LTD., NATIONAL UNIVERSITY CORPORATION TOYOHASHI UNIVERSITY OF TECHNOLOGY, NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Hiroo Wada, Kiyokatsu Jinno, Yoshihiro Saito, Youkichi Ohno, Makiko Hayashida
  • Patent number: 8944991
    Abstract: The invention provides a surgical device for endoscopic surgery having the function of temporarily storing liquid (a first function), the function of keeping a physical space for surgery and a sufficient endoscopic field (a second function), and the function of protecting organs (a third function), and an insertion device for inserting the surgical device into a body. [Solving Means] The surgical device for endoscopic surgery is an inter-organ spacer (10) including liquid holding means (1) formed of a porous soft material having the ability to temporarily store liquid and the ability to retain its shape. The insertion device for inserting the inter-organ spacer into a body includes a tubular holder capable of holding the inter-organ spacer for endoscopic surgery.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: February 3, 2015
    Assignees: Nippon Medical School Foundation, Hogy Medical Co., Ltd.
    Inventors: Yoshiharu Nakamura, Satoshi Matsumoto, Toshiki Inoue
  • Patent number: 8684938
    Abstract: A biological condition evaluation apparatus determines a symptom of a heart abnormality based on at least one index calculated from a heartbeat interval and/or a pulse interval. The apparatus determines whether it is in a referential period where an amount of change in the index is comparatively small. The apparatus determines whether a plurality of conditions are satisfied or not in an evaluation period set after the referential period. One condition is that an amount of change in the index in the evaluation period is greater than that observed during the referential period. Another condition is that a rate of change in the index is equal to or greater than a predetermined threshold value. The apparatus determines that there is a symptom of a heart abnormality, when both the conditions are satisfied.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: April 1, 2014
    Assignees: DENSO CORPORATION, Nippon Medical School Foundation, Toyota Jidosha Kabushiki Kaisha
    Inventors: Kazuhiro Sakai, Shinji Nanba, Takao Katoh, Motohisa Osaka, Yoshitaka Fuwamoto
  • Patent number: 8548578
    Abstract: A living body state monitor apparatus includes: a living body information acquisition device to acquire living body information containing an electrocardiography waveform and a pulse waveform from a user; an irregular heartbeat detection section to detect an irregular heartbeat from the electrocardiography waveform; and a pulse wave feature quantity extraction section to extract a pulse wave feature quantity from a pulse wave corresponding to the irregular heartbeat. Further, a living body state determination section is included to determine a danger degree on user's living body state using both of (A) information on kind and/or continued time period of an irregular heartbeat detected by the irregular heartbeat detection section, and (B) a pulse wave feature quantity extracted by the pulse wave feature quantity extraction section, and/or a variation of the extracted pulse wave feature quantity.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: October 1, 2013
    Assignees: DENSO CORPORATION, Toyota Jidosha Kabushiki Kaisha, Nippon Medical School Foundation
    Inventors: Shinya Matsunaga, Shinji Nanba, Tsuyoshi Nakagawa, Kouki Futatsuyama, Takao Katoh, Hiroshige Murata, Hiroshi Hayashi, Motohisa Osaka, Minoru Makiguchi
  • Patent number: 8318792
    Abstract: A method for treating amyotrophic lateral sclerosis is disclosed wherein a compound having xanthine dehydrogenase inhibiting activity is administered.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: November 27, 2012
    Assignees: Nippon Medical School Foundation, National University Corporation Tottori University
    Inventors: Takeshi Nishino, Yasuko Abe, Shinsuke Kato