Abstract: An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the undifferentiated state thereof and to provide the substance as an agent for maintaining the undifferentiated state of stem cells or an agent for promoting the proliferation of stem cells. Another object of the present invention is to provide an agent for treating a wound that has a wound healing effect on the skin and is readily available in the field of skin regenerative medicine or cosmetic treatment, and safe and inexpensive.

Abstract: An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the undifferentiated state thereof and to provide the substance as an agent for maintaining the undifferentiated state of stem cells or an agent for promoting the proliferation of stem cells. Another object of the present invention is to provide an agent for treating a wound that has a wound healing effect on the skin and is readily available in the field of skin regenerative medicine or cosmetic treatment, and safe and inexpensive.

Abstract: The object of the present invention is to provide a preventive and relieving medicine for activated matrix metalloproteinase-causing disorders and diseases, which contains a solvent extract of Ganoderma mushroom. The preventive and relieving medicine for activated matrix metalloproteinase (MMP)-causing disorders and diseases according to the present invention contains the solvent extract of Ganoderma mushroom. The solvent extract of Ganoderma mushroom has MMP inhibiting behaviors and is effective for prevention, suppression, and symptomatic relief of various activated MMP-causing disorders and diseases, such as metastasis of cancers, ulceration, rheumatoid arthritis, osteoporosis, periodontitis, and aging of skin.