Abstract: This invention has for its object to provide a method of inducing a transition in crystalline state of a crystallizable medicinal substance with great ease and improved efficiency and uniformity on a high production scale. According to the invention, an extruder is used for inducing a transition from one crystalline state (.DELTA.) to another crystalline state in a crystallizable medicinal substance.
Type:
Grant
Filed:
June 9, 1995
Date of Patent:
September 22, 1998
Assignee:
Nippon Shinyaju Co., Ltd.
Inventors:
Kouichi Nakamichi, Shougo Izumi, Masaaki Oka