Patents Assigned to Nippon Soda Company Limited
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Patent number: 5204255Abstract: A hybrid plasminogen activator-like polypeptide comprising a polypeptide region responsible for an affinity to fibrin derived from a tissue plasminogen activator polypeptide and a polypeptide region responsible for an enzyme activity derived from a prourokinase polypeptide; a DNA segment coding for the hybrid polypeptide; plasmid containing the DNA segment; a microorganism transformed with the DNA; and a process for production of the hybrid polypeptide comprising culturing the microorganism and recovering the hybrid polypeptide from the cultured cells.Type: GrantFiled: July 3, 1991Date of Patent: April 20, 1993Assignees: Sagami Chemical Research Center, Central Glass Company, Limited, Hodogaya Chemical Co., Ltd., Nippon Soda Company, Limited, Nissan Chemical Industries, Limited, Toyo Soda Manufacturing Co., Ltd.Inventors: Michito Tagawa, Masakatsu Wada, Masayuki Yamada, Midori Yokoyama, Naganori Numao
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Patent number: 5188829Abstract: A human prourokinase-like polypeptide having the following amino acid sequence:(Met).Ser.sup.1 -X.sup.156.Y.sup.157.Z.sup.158 --wherein Met is an occasionally present methionine, Ser is the first N-terminal serine, X is the 156th arginine or other amino acid, Y is the 157th proline, glycine, alanine or valine, Z is the 158th lysine or arginine, and the solid lines represent the same amino acid sequences as corresponding parts of an amino acid sequence of a natural type human prourokinase or a human prourokinase-like polypeptide wherein the 135th lysine is changed to an amino acid other than a basic amino acid, or substantially the same amino acid sequence as the above-mentioned amino acid sequence, is provided.Moreover, a DNA segment coding for the above-mentioned polypeptide; a plasmid containing the DNA segment; E. coli transformed with the plasmid; a process for production of the polypeptide characterized by culturing the E.Type: GrantFiled: April 10, 1989Date of Patent: February 23, 1993Assignees: Sagami Chemical Research Center, Central Glass Company, Limited, Hodogaya Chemical Co., Ltd., Nippon Soda Company, Limited, Nissan Chemical Industries, Limited, Tosoh CorporationInventors: Yo-ichi Kobayashi, Muneki Omori, Chikako Yamada
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Patent number: 4970157Abstract: An isolated gene coding for phenylalanine dehydrogenase of a microorganism belonging to a genus selected from the group consisting of the genera Bacillus and Sporosarcina origin; plasmids containing the gene; microorganism transformed with the plasmid, a process for the production of phenylalanine dehydrogenase using the microogranism; and a process for the production of L-phenylalanine using the enzyme.Type: GrantFiled: August 11, 1987Date of Patent: November 13, 1990Assignees: Sagami Chemical Research Center, Central Glass Company, Limited, Hodogaya Chemical Co., Ltd., Nippon Soda Company, Limited, Nissan Chemical Industries, Limited, Toyo Soda Manufacturing Co., Ltd.Inventors: Yasuo Hibino, Yasuhisa Asano, Noriko Okazaki, Naganori Numao
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Patent number: 4568766Abstract: 4-Hydroxy-4'-isopropoxydiphenylsulfone useful as color developer for heat-sensitive color-developable recording material.Type: GrantFiled: June 25, 1984Date of Patent: February 4, 1986Assignee: Nippon Soda Company LimitedInventors: Masakichi Yahagi, Tetsuo Igaki, Shinji Yoshinaka, Kosaku Morita, Kimiaki Kinoshita, Masashi Enokiya, Akio Kaneko, Toshiyuki Yamashita
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Patent number: 4532363Abstract: There is a method for the production of 3-phenylpyrrole derivatives having the general formula ##STR1## wherein X is halogen, nitro or haloalkyl having 1 to 3 carbon atoms;n is 0, 1 or 2; andZ is hydrogen or halogen;which comprises reacting a compound having the general formula ##STR2## wherein X and n are as previously defined; andY is hydrogen or halogen;with ammonia or aqueous ammonia in an organic solvent.A compound having the general formula [I] is useful as fungicide or intermediate thereof.Type: GrantFiled: May 30, 1984Date of Patent: July 30, 1985Assignee: Nippon Soda Company LimitedInventors: Akiyoshi Ueda, Humiko Nagasaki, Yutaka Takakura, Shigeru Kojima
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Patent number: 4529552Abstract: Composite oxyalkoxides and their derivatives are novel organometallic compounds which give alkaline earth metal titanates such as barium titanate or strontium titanate by hydrolysis or thermal decomposition. The oxyalkoxides are synthesized by the reaction between an alkoxytitanium and an alkaline earth metal hydroxide, and their derivatives are synthesized by the reaction between the composite oxyalkoxide and a chelating agent.Type: GrantFiled: January 24, 1983Date of Patent: July 16, 1985Assignee: Nippon Soda Company LimitedInventors: Iwao Kato, Yoshihiko Nakamura, Tetsuo Yoshimoto, Masanori Iwamori, Kazuo Ozawa, Makoto Asai
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Patent number: 4515729Abstract: A cyclohexane derivative having the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl or halo phenyl;R.sub.2 is C.sub.1-3 alkyl or cyano group;R.sub.3 is C.sub.1-4 alkyl;R.sub.4 is C.sub.1-4 alkyl or C.sub.1-4 alkenyl;X is straight or branched chain C.sub.1-4 alkylene; andn is 0, 1 or 2,which possess herbicidal properties, and the process for its preparation.Type: GrantFiled: January 26, 1983Date of Patent: May 7, 1985Assignee: Nippon Soda Company LimitedInventors: Isao Iwataki, Kagari Fujita, Hisao Ishikawa, Hideo Hosaka, Kenichi Kohara
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Patent number: 4482740Abstract: A compound having the general formula ##STR1## wherein R.sub.1 is ethyl or allyl; andR.sub.2 is alkyl having 1-4 carbon atoms;and a metal salt of the compound defined herein above.The compound is useful as herbicides.Type: GrantFiled: December 27, 1982Date of Patent: November 13, 1984Assignee: Nippon Soda Company LimitedInventors: Isao Iwataki, Akira Nakayama, Minoru Kaeriyama, Hisao Ishikawa, Hideo Hosaka, Kenichi Kohara, Shozo Yamada
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Patent number: 4476303Abstract: Compounds having the formula ##STR1## wherein R.sub.1 denotes hydrogen atom, halogen group atom or methyl radical,R.sub.2 denotes cyclohexyl radical, phenyl radical or phenyl radical substituted with methyl radical or nitro radical, andX denotes oxygen atom or sulfur atom,are useful for the control of phytophthora diseases and downy mildew of vegetable and fruit trees.The compounds of formula [I] can be prepared by reacting compounds having the formula ##STR2## wherein R.sub.1, R.sub.2 and X are defined previously, are reacted with a carbonic acid derivative in the presence of an acid-binding agent.Type: GrantFiled: February 8, 1983Date of Patent: October 9, 1984Assignee: Nippon Soda Company LimitedInventors: Kuniyasu Maeda, Minoru Kaeriyama, Nobuo Matsui, Masami Mizuno, Yasushi Yasuda, Akira Nakata
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Patent number: 4471126Abstract: There is a method for the production of 3-phenylpyrrole derivatives having the general formula ##STR1## wherein X is halogen, nitro or haloalkyl having 1 to 3 carbon atoms;n is 0, 1 or 2; andZ is hydrogen or halogen;which comprises reacting a compound having the general formula ##STR2## wherein X and n are as previously defined; andY is hydrogen or halogen;with ammonia or aqueous ammonia in an organic solvent.A compound having the general formula [I] is useful as fungicide or intermediate thereof.Type: GrantFiled: April 18, 1983Date of Patent: September 11, 1984Assignee: Nippon Soda Company LimitedInventors: Akiyoshi Ueda, Humihiko Nagasaki, Yutaka Takakura, Shigeru Kojima
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Patent number: 4442116Abstract: A compound of the formula ##STR1## wherein typical representations of X, Y and Z is oxygen or sulfur; R.sub.1 is methyl; R.sub.2 is phenyl substituted with chlor, methyl, methoxy, nitro or methylenedioxy; and R.sub.3 is cyclohexyl, methylcyclohexyl or tetrahydropyranyl, is useful as an acaricide.Type: GrantFiled: February 19, 1982Date of Patent: April 10, 1984Assignee: Nippon Soda Company, LimitedInventors: Isao Iwataki, Minoru Kaeriyama, Nobuo Matsui, Tomio Yamada
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Patent number: 4433079Abstract: Water-dispersion adhesives stable in storage and dilution dispersion and excellent in adhesive properties for extrusion lamination which comprise a dispersion of a resin in water, wherein the resin (A) is obtained from a reaction of a polyepoxy compound (B) with a reaction mixture (C) of a polyethyleneimine (D) and a monoepoxy compound (E).Type: GrantFiled: March 9, 1983Date of Patent: February 21, 1984Assignee: Nippon Soda Company LimitedInventors: Noriyuki Kobayashi, Akihiko Funamoto
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Patent number: 4431814Abstract: A compound of the formula ##STR1## wherein typical representations of X, Y and Z is oxygen or sulfur; R.sub.1 is methyl; R.sub.2 is phenyl substituted with chlor, methyl, methoxy, nitro or methylenedioxy; and R.sub.3 is cyclohexyl, methylcyclohexyl or tetrahydropyranyl, is useful as an acaricide.Type: GrantFiled: February 16, 1982Date of Patent: February 14, 1984Assignee: Nippon Soda Company LimitedInventors: Isao Iwataki, Minoru Kaeriyama, Nobuo Matsui, Tomio Yamada
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Patent number: 4391743Abstract: An organic solution of a composition consisting essentially of 100 parts of an indium compound represented by the formulaIn(X).sub.l (Y).sub.mwherein X denotes a chelate ring formed by .beta.-diketones, esters of .beta.-ketoacids or the like, Y denotes an alkoxide formed by aliphatic alcohols or the like, and l and m denote an integer which is either 1 or 2 having the relationship of l+m=3, and from 5 to 20 parts of a tin compound represented by the formulaSn(X').sub.2 or Sn(Y')m'wherein X' denotes a chelate ring formed by .beta.-diketones or esters of .beta.-ketoacids, Y' denotes an alkoxide formed by aliphatic alcohols, and m' denotes 2 or 4, is suitable for deposition of transparent, hardened and low resistivity film coatings of tin-doped indium oxide on a substrate by dipcoating.Type: GrantFiled: November 30, 1981Date of Patent: July 5, 1983Assignee: Nippon Soda Company LimitedInventors: Umio Maeda, Hirofumi Shoji, Yasusuke Wada, Yoshio Horie
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Patent number: 4355184Abstract: .alpha., .beta.-unsaturated-ketones are synthesized by reacting with an aldehyde and an alkali metal salt of acetoacetic acid in the presence of an aliphatic secondary amine in the mixture of heterogeneous solvents producing an oil layer and a water layer.Type: GrantFiled: April 27, 1981Date of Patent: October 19, 1982Assignee: Nippon Soda Company LimitedInventors: Tsutomu Kaku, Kiyoshi Katsuura, Mikio Sawaki
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Patent number: 4346098Abstract: A fungicidal composition containing as the active component a mixture of (I) a compound having the formula of ##STR1## wherein R.sub.1 is methylene or C.sub.2-4 alkylene, andR.sub.2 is C.sub.1-4 alkyl,and(II) a compound having the formula of ##STR2## wherein R.sub.3 is C.sub.1-2 alkyl.Type: GrantFiled: December 5, 1980Date of Patent: August 24, 1982Assignee: Nippon Soda Company LimitedInventors: Yasushi Yasuda, Masami Mizuno, Hiroaki Nishikawa, Akira Murakami
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Patent number: 4336196Abstract: Sodium salts of phenylmalonic acid mono-esters are produced by reacting a phenylacetic acid ester with carbon dioxide in the presence of a sodium substituted compound, which is prepared by substituting a sodium atom for a hydrogen atom of an organic compound selected from a group consisting of acetylene, cumene, triphenylmethane, methyl-methylthiomethyl-sulfoxide and dimethyl-sulfoxide, at a temperature in a range of -20.degree. C. to -40.degree. C.Type: GrantFiled: July 21, 1980Date of Patent: June 22, 1982Assignees: Nippon Soda Company Limited, Shionogi Company LimitedInventors: Shigeo Kitamura, Kazuo Yoshioka, Yoshiharu Seriyama, Hiroshi Misuta
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Patent number: 4326881Abstract: Compounds of the general formula ##STR1## wherein Xn is 2-Cl, 3-Cl, 2,3-Cl.sub.2 or 3-CF.sub.3, andR is hydrogen or acetyl,with the proviso that Xn is 2,3-Cl.sub.2 in the case of R being hydrogen, are outstanding effective fungicides.Type: GrantFiled: December 18, 1978Date of Patent: April 27, 1982Assignee: Nippon Soda Company LimitedInventors: Akiyoshi Ueda, Hideo Takagi, Kazuhiko Ohkuma
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Patent number: 4321363Abstract: Highly pure urokinase can be produced by affinity chromatography on a novel adsorbent which comprises a water insoluble carrier and a ligand united to the carrier. The ligand is shown by the general formula ##STR1## wherein X is oxygen, sulfur or imino group, and R is amino or carboxyl group.Type: GrantFiled: February 21, 1980Date of Patent: March 23, 1982Assignee: Nippon Soda Company LimitedInventors: Daigaku Takiguchi, Eiji Itou, Hiroaki Nakamura, Izumi Kumita
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Patent number: 4316044Abstract: Isovaleric acid derivatives having the formula ##STR1## wherein typical representations of X is halophenyl, R.sub.1 is hydrogen or cyano, R.sub.2 is hydrogen or lower alkyl, and Y is halophenyl. These derivatives possess insecticidal and acaricidal properties. The process for their preparation is described.Type: GrantFiled: August 29, 1980Date of Patent: February 16, 1982Assignee: Nippon Soda Company LimitedInventors: Keiichi Ishimitsu, Isamu Kasahara, Tomio Yamada, Michihiko Matsuda, Hidemitsu Takahashi, Shuichi Soma