Patents Assigned to Nipro Corporaton
  • S-nitrosoprotein preparation and production method therefor
    Patent number: 7803759
    Abstract: A protein is efficiently nitrosylated with nitrogen monoxide by merely mixing S-nitrosoglutathione as a nitrogen monoxide donor with a protein solution containing a stabilizing agent comprising at least one compound or a combination of plural compounds selected from an N-acetylamino acid, a fatty acid, and a fatty acid salt. The method that enables efficient NO addition to a cysteine residue in un-nitrosylated protein without changing the structure of protein and hence provides NO to a living organism.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: September 28, 2010
    Assignee: Nipro Corporaton
    Inventors: Yu Ishima, Takaaki Akaike, Masaki Otagiri