Patents Assigned to NIRvana Sciences
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Patent number: 11999885Abstract: Provided are fluorescent microparticles and/or nanoparticles that have a polymeric matrix and at least one porphyrinic macrocycle associated therewith. The porphyrinic macrocycles associated with the presently disclosed fluorescent microparticles and/or nanoparticles are in some embodiments selected from the group consisting of porphyrins (including 17,18-didehydrophorbines), chlorins (including phorbines), bacteriochlorins (including bacteriophorbines), and isobacteriochlorins (including isobacteriochlorins containing a fused āEā ring). In some embodiments, the porphyrinic macrocycles have structures selected from Formulas I and H.Type: GrantFiled: June 12, 2017Date of Patent: June 4, 2024Assignee: NIRVANA SCIENCES INC.Inventors: James Bruce Pitner, Rosemary B. Evans-Storms, Duane A. Olsen
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Publication number: 20240082431Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.Type: ApplicationFiled: January 4, 2022Publication date: March 14, 2024Applicant: NIRvana Sciences, Inc.Inventors: James Bruce Pitner, Russell D. Thomas, Joshua O. Akhigbe
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Patent number: 11904026Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.Type: GrantFiled: January 4, 2021Date of Patent: February 20, 2024Assignee: NIRvana Sciences Inc.Inventors: James Bruce Pitner, Russell D. Thomas, Joshua O. Akhigbe
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Publication number: 20220249708Abstract: Provided are bacteriochlorin derivatives with narrow band emission. In some embodiments, the bacteriochlorin derivatives are PEGylated. In some embodiments, the bacteriochlorin derivatives have high water solubility (e.g., 10 mg/mL or more). In some embodiments the bacteriochlorin derivatives are PEGylated and have high water solubility. The bacteriochlorin derivatives can include bioconjugatable groups for forming conjugates, for example, with antibodies and nanoparticles. The bacteriochlorin derivatives and their conjugates can be used in imaging and therapeutic applications. Methods of synthesizing the bacteriochlorin derivatives are also provided.Type: ApplicationFiled: May 19, 2020Publication date: August 11, 2022Applicant: NIRvana Sciences Inc.Inventors: Christopher J. MacNevin, Chih-Yuan Chen
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Publication number: 20220249707Abstract: Provided are chlorin derivatives with narrow band emission. In some embodiments, the bacteriochlorin derivatives are PEGylated. In some embodiments, the chlorin derivatives have high water solubility (e.g., 10 mg/mL or more). In some embodiments, the chlorin derivatives are PEGylated and have high water solubility. The chlorin derivatives can include bioconjugatable groups for forming conjugates, for example, with antibodies and nanoparticles. The chlorin derivatives and their conjugates can be used in imaging and therapeutic applications. Methods of synthesizing the chlorin derivatives are also provided.Type: ApplicationFiled: May 19, 2020Publication date: August 11, 2022Applicant: NIRvana Sciences Inc.Inventors: Christopher J. MacNevin, James Bruce Pitner, Chih-Yuan Chen
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Publication number: 20210361783Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.Type: ApplicationFiled: January 4, 2021Publication date: November 25, 2021Applicant: NIRvana Sciences Inc.Inventors: James Bruce Pitner, Russell D. Thomas, Joshua O. Akhigbe
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Publication number: 20200009272Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a bacteriochlorin, a metallobacteriochlorin, a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed bacteriochlorins, metallobacteriochlorins, and/or derivatives thereof simultaneously.Type: ApplicationFiled: February 2, 2018Publication date: January 9, 2020Applicant: NIRvana Sciences Inc.Inventors: James Bruce Pitner, Rajalekha Manjakuppam Rajamahendiran, Russell D. Thomas
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Publication number: 20190264102Abstract: Provided are fluorescent microparticles and/or nanoparticles that have a polymeric matrix and at least one porphyrinic macrocycle associated therewith. The porphyrinic macrocycles associated with the presently disclosed fluorescent microparticles and/or nanoparticles are in some embodiments selected from the group consisting of porphyrins (including 17,18-didehydrophorbines), chlorins (including phorbines), bacteriochlorins (including bacteriophorbins), and isobacteriochlorins (including isobacteriochlorins containing a fused āEā ring). In some embodiments, the porphyrinic macrocycles have structures selected from Formulas I and H.Type: ApplicationFiled: June 12, 2017Publication date: August 29, 2019Applicant: NIRvana SciencesInventors: James Bruce Pitner, Rosemary B. Evans-Storms, Duane A. Olsen