Patents Assigned to Nisshin Oil Mills, Ltd.
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Patent number: 5380829Abstract: Disclosed are thioglycoside analogs of gangliosides represented by the formula ##STR1## in which Y represents a radical of the following formula ##STR2## and X represents a radical of the formula ##STR3## wherein m is an integer of 15 to 25, l is an integer of 0 to 3 and n is an integer of 11 to 15. The thioglycoside analogs are expected to exert specific enzyme-inhibitory effects.Type: GrantFiled: February 27, 1992Date of Patent: January 10, 1995Assignees: The Nisshin Oil Mills, Ltd., Akira HasegawaInventors: Akira Hasegawa, Makoto Kiso
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Patent number: 5371202Abstract: An improved process for the preparation of O-glycosyl compounds of sialic acid, which are useful as intermediates in the synthesis of sialoconjugated glycosides. This process comprises effecting condensation reaction between thioglycosides of sialic acid and sugar derivatives in the presence of N-iodosuccinimide and trifluoromethanesulfonic acid. O-glycosyl compounds of sialic acid are prepared in high resio- and stereo-selectivity and in high yields.Type: GrantFiled: February 12, 1992Date of Patent: December 6, 1994Assignee: The Nisshin Oil Mills, Ltd.Inventor: Akira Hasegawa
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Patent number: 5369096Abstract: Disclosed are glycolipid derivatives of formula (I) ##STR1## wherein X is a group selected from ##STR2## n is 0 or an integer of 1-10 and R denotes a branched hydrocarbon chain containing from 19 to 39 carbon atoms. Those compounds are useful as antiinflammatory agents, or as agents for the treatment of rheumatoid arthritis.Type: GrantFiled: July 15, 1993Date of Patent: November 29, 1994Assignee: The Nisshin Oil Mills, Ltd.Inventors: Yutaka Yamada, Naofumi Takahashi, Keisuke Adachi, Akihiko Kameyama
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Patent number: 5305476Abstract: A shower bathing device comprising a passage through which hot water is passed, a chamber filled with a medical solution to supply the medical solution into the passage, a stream pump for mixing the medical solution in the chamber with hot water passing through the passage, and a screw inserted into a through hole for adjusting the amount of the medical solution supplied to the stream pump, wherein hot water can be showered while including a desired density of medicine therein.Type: GrantFiled: April 15, 1993Date of Patent: April 26, 1994Assignee: The Nisshin Oil Mills, Ltd.Inventors: Keiichi Ohyama, Ayami Inaba, Takashi Murata
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Patent number: 5252761Abstract: A branched monoester represented by the formula R.sup.1 COOR.sup.2 acts as a silicone-dissolving or solubilizing agent. In the formula, R.sup.1 is an isoalkyl group having 4 to 17 carbon atoms, and R.sup.2 is an isoalkyl group having 3 to 18 carbon atoms.Type: GrantFiled: December 27, 1990Date of Patent: October 12, 1993Assignee: The Nisshin Oil Mills, Ltd.Inventors: Tadashiro Hirose, Yoshihiro Ueda, Yoshiaki Takagi
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Patent number: 5227403Abstract: A nutrient comprising fats and oils having superior digestibility and absorptivity are provided, which fats and oils are comprised of at least one triglyceride having fatty acids of C.sub.8 to C.sub.14 at the 2-position of the triglyceride and identical unsaturated acids of C.sub.18 or higher at both the 1- and 3-positions thereof. Examples of the unsaturated fatty acids of C.sub.18 or higher are linolic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.Type: GrantFiled: October 23, 1991Date of Patent: July 13, 1993Assignee: The Nisshin Oil Mills, Ltd.Inventors: Akira Seto, Osamu Yamada
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Patent number: 5183675Abstract: A process for producing a salad oil comprises transesterifying a mixture of (A) an oil or fat produced from palm oil and having the following characteristics:______________________________________ iodine value: 55 to 75 constituent fatty acids: palmitic acid: 30 to 42% by weight oleic acid: 42 to 48% by weight linoleic acid: 11 to 20% by weight tripalmitin: 2% by weight or less open-tube melting point: 5 to 25.degree. C. ______________________________________and (B) a liquid edible oil other than the component (A) in a weight ratio of 5:95 to 95:5 with immobilized lipase having 1,3-specificity in the absence of solvent and then fractionating the product in the absence of solvent. Thereby, the salad oil can be efficiently derived from palm oil which is a solid oil and the relative amount of the starting material obtained from palm oil in the salad oil can be increased. The thus-produced salad oil has a satisfactory cooling resistance.Type: GrantFiled: July 9, 1991Date of Patent: February 2, 1993Assignee: The Nisshin Oil Mills, Ltd.Inventors: Koichi Tamura, Nobuo Taguchi, Satoshi Tashiro
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Patent number: 5176909Abstract: A stable immunogen composition for oral administration which includes a dried spherical form comprised of an immunogen capable of immunizing human or animals and a gelatin having an average molecular weight of 80,000-120,000 and jelly strength of more than 150 (Bloom, g, 6.2/3%), and is enteric.Type: GrantFiled: September 28, 1990Date of Patent: January 5, 1993Assignee: The Nisshin Oil Mills, Ltd.Inventors: Kuniaki Nerome, Kuniharu Seki, Katsuhiko Ohyama
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Patent number: 5100787Abstract: A method for preparing highly purified phosphatidylinositol comprises the steps of treating a mixed phospholipid with a phospholipase D, then treating the product with an alkali or acidic phosphatase and separating unreated phosphatidylinositol from the reaction mixture. The method makes it possible to isolate phosphatidylinositol useful in various fields in a high purity in the order of 80 to 99%.Type: GrantFiled: July 30, 1990Date of Patent: March 31, 1992Assignee: The Nisshin Oil Mills, Ltd.Inventors: Shoichi Shimizu, Tsuneo Yamane, Dongxiu Li, Lekh R. Juneja
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Patent number: 5081048Abstract: An agent or device for the determination of antigen or antibody comprising capsules of a water-insoluble, dye-permeable polymer or a liquor-pool covered by said polymer, an antien, antibody or hapten immobilized on the surface of said polymer, and a dye solution enclosed or held in said capsules or liquor-pool, and a method for determining antigen or antibody using said agent or device, which can be conveniently used for the serodiagnosis of various diseases.Type: GrantFiled: March 10, 1989Date of Patent: January 14, 1992Assignee: The Nisshin Oil Mills, Ltd.Inventors: Yoshio Okahata, Naofumi Takahashi, Takuro Sada
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Patent number: 5077202Abstract: A process for producing a glycolipid having a high eicosapentaenoic acid (EPA) content is provided, which process comprises fractionating the whole lipids of marine chlorella by means of a combination of solvent-fractionation with column chromatography, which glycolipid has platelet agglutination-inhibiting effect, serum cholesterol-increase-inhibiting effect, etc. of EPA and also having a higher absorption rate in intestinal canal than EPA triglyceride or ethyl ester.Type: GrantFiled: August 28, 1985Date of Patent: December 31, 1991Assignee: Nisshin Oil Mills, Ltd.Inventors: Akira Seto, Kiyohiro Kitagawa, Shoko Yamashita, Tadasu Fujita
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Patent number: 5026644Abstract: A lipid composition having a high .gamma.-linolenic acid content is prepared by culturing mold fungi of the genus Cunninghamella in an aqueous nutrient culture medium having a relatively high concentration of a carbon source, and the lipid composition is recovered from the cultured mold fungi.Type: GrantFiled: September 6, 1989Date of Patent: June 25, 1991Assignee: The Nisshin Oil Mills, Ltd.Inventors: Yumiko Manoh, Akira Seto
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Patent number: 4956109Abstract: Herein disclosed is a lubricating oil comprising at least one member selected from the group consisting of esterified products obtained by reacting: (A) a compound selected from the group consisting of alcohols represented by the following general formula (I), alcohols represented by the following general formula (II) and hydrogenated derivatives thereof; with (B) a fatty acid having not less than 6 carbon atoms or a mixture of the fatty acid with a rosin selected from the group consisting of rosin, hydrogenated rosins, disproportionated rosins and polymerized rosins: ##STR1## in the general formulas (I) and (II), X.sub.1 and X.sub.2 each independently represents a hydrogen atom or a methyl group and n is an integer ranging from 0 to 10. The lubricating oil is used as rolling mill oils, hydraulic oils cutting-grinding oils, lubricating oils for metal plastic working and those for internal combustion engines.Type: GrantFiled: May 26, 1989Date of Patent: September 11, 1990Assignees: The Nisshin Oil Mills, Ltd., Nippon Steel CorporationInventors: Keiichi Tanikawa, Higaki Yuzo
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Patent number: 4954443Abstract: Enzymes or microorganisms are immobilized by bringing a first aqueous solution into contact with a second aqueous solution containing metal ions having a valence of 3 or more. The first solution contains enzymes or microorganisms, and at least one immobilizing agent selected from the group consisting of Xanthan gum and derivatives thereof. The immobilizing agent is thereby hardened in a state to enclose the enzymes or microorganisms. Preferably, the metal ions are iron, tin, manganese or titanium ions.Type: GrantFiled: November 18, 1988Date of Patent: September 4, 1990Assignee: The Nisshin Oil Mills, LTD.Inventors: Osamu Yamada, Tadasu Fujita
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Patent number: 4931291Abstract: Feeds comprising unicellular algaes whose cell wall are disrupted are provided as the feeds for larvae of crustaceans and shellfishes to be cultivated. With such feeds, it is possible to achieve the rates of survival and growth equivalent to, or higher than, those achieved with untreated diatom.Type: GrantFiled: July 12, 1988Date of Patent: June 5, 1990Assignee: The Nisshin Oil Mills, Ltd.Inventors: Eiji Kojima, Kiyohiro Kitagawa, Akira Seto
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Patent number: 4906479Abstract: A feedstuff for cultivating Artemia as a feedstuff for larvae of cultivated fishes or crustaceans is provided, which feedstuff for cultivation is a product obtained by treatment of breaking the cell wall of monocellular algae, the thus obtained Artemia having a high survival rate, the body length thereof being large and the content of eisacopentaenoic acid and docosahexaenoic acid in the total fatty acids therein being much higher than those of conventional feedstuffs.Type: GrantFiled: May 11, 1988Date of Patent: March 6, 1990Assignee: The Nisshin Oil Mills, Ltd.Inventors: Kiyohiro Kitagawa, Eiji Kojima, Akira Seto, Shuichi Sakamoto, Takuji Nozawa
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Patent number: 4897280Abstract: A processed soybean curd (tofu) food having a texture similar to meat. The food contains soybean curd and a fibrous soybean protein material mixed therein. The protein material is prepared by using a single or twin screw extruder.Type: GrantFiled: August 28, 1987Date of Patent: January 30, 1990Assignee: The Nisshin Oil Mills, Ltd.Inventor: Hideo Ohtsu
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Patent number: 4895835Abstract: Muramyl peptide derivatives having the formula (I) ##STR1## wherein R.sub.3 is a long chain acyloxyacyl group, R.sub.1 is hydrogen or hydroxy mercapto, acyloxy or acylthio group, R.sub.2 is hydrogen or alkyl group and R.sub.4 is acyl, which are useful as immunomodulators.Type: GrantFiled: November 17, 1988Date of Patent: January 23, 1990Assignee: Nisshin Oil Mills, Ltd.Inventor: Akira Hasegawa
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Patent number: 4891161Abstract: A cold rolling mill lubricant for steel sheets, contains a monoester oil represented by general formula (A):R.sup.1 COO--(R.sup.2 --O).sub.n --R.sup.3(Wherein R.sup.1 is an alkyl, alkenyl, hydroxyalkyl, or hydroxyalkenyl group having 7 or more carbon atoms, R.sup.2 is an alkylene group, R.sup.3 is an alkyl or phenyl group, and n is an integer of 1 to 5), and/or a diester oil represented by general formula (B): ##STR1## (wherein each R.sup.4 or R.sup.6 is independently an alkyl, alkenyl, hydroxyalkyl or hydroxyalkenyl group having 5 or more carbon atoms, R.sup.5 is an alkylene group having 2 to 4 carbon atoms, and m is an integer of 1 or more).Type: GrantFiled: February 24, 1986Date of Patent: January 2, 1990Assignees: Nisshin Oil Mills, Ltd., Nippon Steel Corp.Inventors: Keiichi Tanikawa, Yuji Fujioka, Yuzo Higaki, Hiroyuki Goto
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Patent number: 4889648Abstract: Lubricating oils for rolling of steel plates, which are composed of synthetic ester compounds obtainable from tri- or higher-valent alcohols having tertiary nitrogen such as isocyanuric derivatives or ethylene oxide addition products of ethylenediamine and fatty acids, possess well-balanced rolling lubricating properties and mill cleanability at a high level.Type: GrantFiled: July 18, 1988Date of Patent: December 26, 1989Assignees: The Nisshin Oil Mills, Ltd., Nippon Steel CorporationInventors: Yuzo Higaki, Hiroyuki Goto, Keiichi Tanikawa