Abstract: A plant-growth-promoting agent is provided, which is lower in environmental pollution, highly safe and harmless to human bodies, and which exhibits an excellent plant growth-promoting action even under wide temperature conditions from low temperatures to high temperatures. A plant growth-promoting agent is also provided, which has an ability to store ubiquinone, as an active ingredient of the plant-growth-promoting agent, in a stable state and can be dispersed and stably present in a medium such as a soil or an aqueous liquid which supplies nutrition to the plant, especially in an initial stage in which a plant body is grown after germination.

Abstract: The present invention provides a composition that exhibits favorable fat absorption inhibitory activity, is capable of being safely and easily taken continuously without side effects, and further is capable of preventing and/or improving conditions associated with excessive fat absorption such as obesity and hyperlipidemia. The present invention relates to a fat absorption inhibitory composition, which contains as an active ingredient a component that is collected as insoluble matter obtained by extracting wheat germ with water at 65° C. or lower and pH 5.0 or lower and treating the extract at 70° C. or higher and pH 6.0 or higher.

Abstract: A composition for effectively preventing or treating peptic ulcers not caused by Helicobacter pylori that does not cause any adverse reaction and thus is highly safe is provided. The present invention relates to a composition for preventing and/or treating peptic ulcers not caused by Helicobacter pylori, which comprises as an active ingredient a browning reaction product of a sugar and a protein.

Abstract: A water-soluble composition comprising (A) coenzyme Q10 of 5-40% by weight, (B) monoester of polyglycerol with average polymerization degree of 10 and fatty acid with 18 carbon atoms of 5-30% by weight, (C) mono-, di-, tri- or penta-ester of polyglycerol with average polymerization degree of 3-6 and fatty acid with 18 carbon atoms of 1-18% by weight, and (D) water, wherein its average particle diameter is 110 nm or smaller. It is superior in acid resistance, salt-resistance and heat resistance, and further enables to maintain the good water-soluble state being blended to medicines, foods and beverages, cosmetics, feeds, additives usually employed therein.

Abstract: There is provided a coenzyme Q10-containing composition having a high coenzyme Q10 content and excellent stability and bioavailability of coenzyme Q10, without using synthetic emulsifiers such as glycerin fatty acid esters, polyglycerin fatty acid esters, organic acid monoglycerides or sucrose fatty acid esters. The coenzyme Q10-containing liquid composition is obtained by dispersing and emulsifying coenzyme Q10 in an aqueous liquid containing a water-soluble substance consisting of octenylsuccinate starch and dextrin, and glycerin. The liquid composition may be dried to prepare a coenzyme Q10-containing solid composition.

Abstract: There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxy-carbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid ? antagonistic activity and are useful for the treatment or prevention of side effects which are caused by ? receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

Abstract: This invention relates to a composition comprising ubiquinone having superior dispersion-stability in an aqueous solution and high bioavailability. The ubiquinone(s) is dispersed and emulsified in an aqueous solution of a water-soluble material in the presence of an organic acid(s) to form a protective colloid, the average particle size of the suspended particles being not more than 5 ?m. The liquid composition can be adsorbed in or carried on an excipient, or dried.

Abstract: This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

Abstract: The process for the preparation of amylase inhibitor including the steps of: (A) obtaining an extract solution containing the amylase inhibitor; (B) insolubilizing the amylase inhibitor by salting out by addition of a salt or salts to the solution obtained in the step (A) and recovering the insolubilized substance resulting from the salting out; and (C) directly drying the insolubilized substance recovered in the step (B) or dissolving the insolubilized substance in water to prepare an aqueous solution, and desalting and drying the aqueous solution to recover the amylase inhibitor, whereby, an amylase inhibitor in high concentrations 0.19 AI is prepared that shows highly inhibitive activity against the amylase in high yield and with good productivity.

Abstract: An inhibitor of Helicobacter pylori colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to H. pylori urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which H. pylori urease is immobilized. The glycoprotein is able to effectively inhibit H. pylori colonization, so is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.

Abstract: An inhibitor composition of Helicobacter pylori adhesion in the stomach comprises (1) anti-urease antibodies obtained from eggs laid by hens which have been immunized against H. pylori urease and (2) an inhibitor of gastric acid secretion. This inhibitor is capable of completely eliminating H. pylori from the stomach, so it is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers.

Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori. At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.

Abstract: The process for the preparation of amylase inhibitor comprises:

Abstract: Disclosed are optically active alcohols having formulae (1) and (2) wherein R is (R)-1-phenylethylamino or (S)-1-phenylethylamino.

Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori . At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.

Abstract: Optically active alcohols of formulae (1) and (2) which are useful as intermediates for the synthesis of (RRR)-optical isomers of 1,4-benzodioxin-2-carboxylic acid derivatives which are useful as a prophylactic and therapeutic agent for diabetes, hyperglycemia and the like.

Abstract: In a process for the preparation of pentaacetyl-&bgr;-D-glucopyranose by reacting D-glucose with acetic anhydride in the presence of sodium acetate catalyst, the improvement is provided wherein 5-10 mols of acetic anhydride are used per mol of D-glucose and the reaction is performed in an organic solvent. Pentaacetyl-&bgr;-D-glucopyranose is useful as intermediates for the synthesis of raw materials for industrial chemicals, medicines, cosmetics and the like.

Abstract: A process of making arbutin and its derivatives comprises solvolyzing an acylated precursor of arbutin or its derivative in a solution comprising an organic solvent and a base, neutralizing the solution with an acid, and crystillizing the product arbutin or its derivative. The process may be employed on an industrial scale and avoids the use of ion exchange columns. The process has the advantages of not requiring ion exchange columns and peripheral devices, which leads to cost and time savings, due to the elimination of column regeneration steps. Waste water from column regeneration is also eliminated.

Abstract: Disclosed are optically active alcohols having formula (1) and (2) wherein R is (R)-1-phenylethylamino or (S)-1-phenylethylamino

Abstract: A process of selectively separating and purifying eicosapentaenoic and docosahexaenoic acids or the esters thereof from a mixture comprising a highly unsaturated fatty acid or the derivative thereof, which comprises the steps of: flowing an aqueous medium comprising a silver salt through a column filled with a diatomaceous earth to carry the silver salt on the diatomaceous earth; flowing a solvent solution of a mixture comprising the highly unsaturated fatty acid or the derivative thereof through the silver salt-carried diatomaceous earth in the column; and flowing a developing solvent through the column.