Abstract: The invention provides methods for treating various indications and diseases in a patient in need thereof, wherein the patient has a C825T polymorphism in the G protein beta3 subunit (GNB3), comprising administering to the patient (i) at least one antioxidant compound or a pharmaceutically acceptable salt thereof; (ii) at least one nitric oxide enhancing compound; and (iii) optionally the best current therapy for the treatment of cardiovascular diseases. In one embodiment the antioxidant is a hydralazine compound or a pharmaceutically acceptable salt thereof and the nitric oxide enhancing compound is isosorbide dinitrate and/or isosorbide mononitrate.
Type:
Application
Filed:
April 4, 2007
Publication date:
December 10, 2009
Applicants:
NitoMed, Inc., Unversity of Pittsburgh of the Commonwealth System of the Higher Education
Inventors:
Manuel Worcel, Michael Sabolinski, Sang W. Tam, Dennis M. McNamara