Patents Assigned to Nitto Denko Avecia, Inc.
  • Process for the manufacture of oligonucleotides
    Patent number: 8513404
    Abstract: A process for manufacturing an oligonucleotide which comprises removing ?-eliminating phosphorus-protecting groups, in particular ?-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: August 20, 2013
    Assignee: Nitto Denko Avecia, Inc.
    Inventors: Tadeusz Krzysztof Wyrzykiewicz, Hagen Cramer, Huihe Zhu, Kevin James Finn