Patents Assigned to Nitto Pharmaceutical Industries Ltd.
  • Patent number: 10952983
    Abstract: The invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 23, 2021
    Assignees: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun Ogawa, Shigenobu Kishino, Teruo Kawada, Nobuyuki Takahashi, Tsuyoshi Goto, Yasunori Yonejima
  • Publication number: 20210079432
    Abstract: The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.
    Type: Application
    Filed: August 30, 2018
    Publication date: March 18, 2021
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Kohey KITAO
  • Publication number: 20210069141
    Abstract: The present invention provides an anti-inflammatory agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the anti-inflammatory agent.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Teruo KAWADA, Nobuyuki TAKAHASHI, Tsuyoshi GOTO, Tatsuya SUGAWARA, Yasunori YONEJIMA
  • Publication number: 20200101036
    Abstract: The invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.
    Type: Application
    Filed: December 11, 2019
    Publication date: April 2, 2020
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Teruo KAWADA, Nobuyuki TAKAHASHI, Tsuyoshi GOTO, Yasunori YONEJIMA
  • Patent number: 10548868
    Abstract: The present invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 4, 2020
    Assignees: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun Ogawa, Shigenobu Kishino, Teruo Kawada, Nobuyuki Takahashi, Tsuyoshi Goto, Yasunori Yonejima
  • Patent number: 10507222
    Abstract: The present invention provides a lactobacillus that improves hyperuricemia, fatty liver and a lifestyle-related disease, and a composition containing the lactobacillus.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: December 17, 2019
    Assignee: NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Yasunori Yonejima, Keiko Hisa, Yoshie Uchibori
  • Publication number: 20190256876
    Abstract: The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from lactobacillus and using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.
    Type: Application
    Filed: May 6, 2019
    Publication date: August 22, 2019
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Teruo KAWADA, Nobuyuki TAKAHASHI, Tsuyoshi GOTO, Yasunori YONEJIMA
  • Publication number: 20190223464
    Abstract: The present invention provides lactic acid bacterium-containing chocolate containing a lactic acid bacterium in a living state, wherein the average particle size of the solid particles in the lactic acid bacterium-containing chocolate is larger than 1 ?m and less than 9 ?m, and a manufacturing method thereof.
    Type: Application
    Filed: August 10, 2017
    Publication date: July 25, 2019
    Applicants: NITTO PHARMACEUTICAL INDUSTRIES, LTD., LOTTE CO., LTD.
    Inventors: Hiroaki ASHITANI, Toshiyuki KOYAMA, Yoko USAMIKRANK, Yusuke KABUKI, Yasunori YONEJIMA, Keiko HISA
  • Publication number: 20190218579
    Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
    Type: Application
    Filed: March 29, 2019
    Publication date: July 18, 2019
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Sakayu SHIMIZU, Yasunori YONEJIMA
  • Patent number: 10294501
    Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: May 21, 2019
    Assignees: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun Ogawa, Shigenobu Kishino, Sakayu Shimizu, Yasunori Yonejima
  • Patent number: 10285966
    Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 14, 2019
    Assignees: NITTO PHARMACEUTICAL INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Yasunori Yonejima, Jun Ogawa, Shigenobu Kishino
  • Patent number: 10287234
    Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 14, 2019
    Assignees: NITTO PHARMACEUTICAL INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Yasunori Yonejima, Jun Ogawa, Shigenobu Kishino
  • Publication number: 20190099438
    Abstract: The present invention provides a prophylactic or therapeutic composition for a metabolic disorder, a composition for amplifying the amount of short-chain fatty acid in the intestine, or a composition for decreasing a ratio of bacteria belonging to the Firmicutes to bacteria belonging to the Bacteroidetes in the intestine, each containing an exopolysaccharide produced by Leuconostoc mesenteroides, and further, a food, a pharmaceutical product, a feed and the like containing the composition.
    Type: Application
    Filed: February 24, 2017
    Publication date: April 4, 2019
    Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Ikuo KIMURA, Kenji YAMAMOTO, Keiko HISA
  • Publication number: 20180318248
    Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
    Type: Application
    Filed: June 2, 2016
    Publication date: November 8, 2018
    Applicants: NITTO PHARMACEUTICAL INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Yasunori YONEJIMA, Jun OGAWA, Shigenobu KISHINO
  • Patent number: 10093749
    Abstract: Provided are exopolysaccharide produced by novel lactic acid bacteria having an IgA production promoting ability, a production method of the exopolysaccharide, a composition containing the exopolysaccharide, and the like.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: October 9, 2018
    Assignee: NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Kenji Yamamoto, Chiaki Matsuzaki, Keiko Hisa
  • Publication number: 20180170854
    Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
    Type: Application
    Filed: June 2, 2016
    Publication date: June 21, 2018
    Applicants: NITTO PHARMACEUTICAL INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Yasunori YONEJIMA, Jun OGAWA, Shigenobu KISHINO
  • Publication number: 20170335355
    Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
    Type: Application
    Filed: June 21, 2017
    Publication date: November 23, 2017
    Applicants: KYOTO UNIVERSITY, NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Jun OGAWA, Shigenobu KISHINO, Sakayu SHIMIZU, Yasunori YONEJIMA
  • Patent number: 9719115
    Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: August 1, 2017
    Assignees: Kyoto University, Nitto Pharmaceutical Industries, Ltd.
    Inventors: Jun Ogawa, Shigenobu Kishino, Sakayu Shimizu, Yasunori Yonejima
  • Publication number: 20170202890
    Abstract: The present invention provides a lactobacillus that improves hyperuricemia, fatty liver and a lifestyle-related disease, and a composition containing the lactobacillus.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 20, 2017
    Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Yasunori YONEJIMA, Keiko HISA, Yoshie UCHIBORI
  • Patent number: 9707200
    Abstract: The present invention provides a metabolism improving agent comprising an oxo fatty acid having 18 carbon atoms and a carbonyl group at the 10- or 12-position, and/or a hydroxy fatty acid having 18 carbon atoms and a hydroxyl group at the 10- and/or 12-position(s), and use of the metabolism improving agent as a food, a pharmaceutical product and the like.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: July 18, 2017
    Assignees: Kyoto University, Nitto Pharmaceutical Industries, Ltd.
    Inventors: Jun Ogawa, Shigenobu Kishino, Si-Bum Park, Teruo Kawada, Nobuyuki Takahashi, Tsuyoshi Goto, Hidekazu Kim, Tatsuya Sugawara, Takashi Hirata, Yasunori Yonejima