Patents Assigned to Nivalis Therapeutics, Inc.
  • Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9856219
    Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: January 2, 2018
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
    Patent number: 9814700
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: November 14, 2017
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Jan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
  • Chromone inhibitors of S-nitrosoglutathione reductase
    Patent number: 9717706
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: August 1, 2017
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Jan Wasley
  • S-nitrosoglutathione reductase inhibitors
    Patent number: 9707212
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: July 18, 2017
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu
  • Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
    Patent number: 9498466
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 22, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Jan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
  • Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9433618
    Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: September 6, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9364481
    Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: June 14, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9315462
    Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: April 19, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Dihydropyridin-2(1H)-one compounds as -nitrosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists
    Patent number: 9283213
    Abstract: The present invention is directed to novel dihydropyridin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors and/or Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: March 15, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu
  • Dihydropyrimidin-2(1H)-one compounds as -nitrosoglutathione reductase inhibitors
    Patent number: 9283229
    Abstract: The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: March 15, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu
  • Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9249132
    Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: February 2, 2016
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9221810
    Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: December 29, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • S-nitrosoglutathione reductase inhibitors
    Patent number: 9187447
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: November 17, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu
  • Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
    Patent number: 9180119
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: November 10, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Jan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
  • Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
    Patent number: 9138427
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: September 22, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Jan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
  • Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9139528
    Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: September 22, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout
  • Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9067893
    Abstract: The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: June 30, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu
  • Pyrrole inhibitors of S-nitrosoglutathione reductase
    Patent number: 9029402
    Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: May 12, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Jan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
  • Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
    Patent number: 9012646
    Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: April 21, 2015
    Assignee: Nivalis Therapeutics, Inc.
    Inventors: Xicheng Sun, Jian Qiu, Adam Stout