Abstract: Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-?) in a subject in need thereof.
Type:
Application
Filed:
October 27, 2005
Publication date:
January 1, 2009
Applicant:
NKUADA, LLC
Inventors:
James F. Burns, Leonardo A. Cabana, Glenn C. Collupy, John R. Didsbury, Tatyana A. Dyakonov, Simon N. Haydar, Michael L. Jones, Francine F. Li, Christopher J. Markworth, Jessymol Mathew, Frank J. Schoenen, David S. Van Vliet, David Middlemiss