Patents Assigned to NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat Tubingen
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Patent number: 11098081Abstract: Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of polypeptides of interest, which comprise the tag. The tag is specifically recognized by an epitope specific antibody, which can be used to detect, capture, quantify, and/or purify polypeptides of interest that are tagged with the epitope. Also provided is novel epitope specific antibody.Type: GrantFiled: March 11, 2019Date of Patent: August 24, 2021Assignees: Chromo Tek GmbH, NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Ulrich Rothbauer, Oliver Poetz, Tina Romer, Andrea Buchfellner, Larisa Yurlova, Kourosh Zolghadr, Jaqueline Bogner, Benjamin Ruf, Christian Linke-Winnebeck, Michael Metterlein
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Publication number: 20200040033Abstract: Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of polypeptides of interest, which comprise the tag. The tag is specifically recognized by an epitope specific antibody, which can be used to detect, capture, quantify, and/or purify polypeptides of interest that are tagged with the epitope. Also provided is novel epitope specific antibody.Type: ApplicationFiled: March 11, 2019Publication date: February 6, 2020Applicants: ChromoTek GmbH, NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Ulrich Rothbauer, Oliver Poetz, Tina Romer, Andrea Buchfellner, Larisa Yurlova, Kourosh Zolghadr, Jaqueline Bogner, Benjamin Ruf, Christian Linke-Winnebeck, Michael Metterlein
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Patent number: 10273265Abstract: Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of polypeptides of interest, which comprise the tag. The tag is specifically recognized by an epitope specific antibody, which can be used to detect, capture, quantify, and/or purify polypeptides of interest that are tagged with the epitope. Also provided is novel epitope specific antibody.Type: GrantFiled: November 16, 2016Date of Patent: April 30, 2019Assignees: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITÄT TÜBINGEN, CHROMOTEK GMBHInventors: Ulrich Rothbauer, Oliver Poetz, Tina Romer, Andrea Buchfellner, Larisa Yurlova, Kourosh Zolghadr, Jaqueline Bogner, Benjamin Ruf, Christian Linke-Winnebeck, Michael Metterlein
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Patent number: 10274485Abstract: A method of detecting biomolecules present in a complex biological sample includes a) separating the biological sample into fractions according to at least one physical property of the biomolecules; and b) specifically detecting biomolecules present in the fractions using at least one solid-phase-based, immunological detection method including immobilizing the biomolecules from the individual fractions on microsphere populations specific for each fraction and distinguishable from one another.Type: GrantFiled: June 27, 2012Date of Patent: April 30, 2019Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Markus Templin, Fridolin Treindl, Anette Doettinger, Oliver Poetz
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Patent number: 10125166Abstract: Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of polypeptides of interest, which comprise the tag. The tag is specifically recognized by an epitope specific antibody, which can be used to detect, capture, quantify, and/or purify polypeptides of interest that are tagged with the epitope. Also provided is novel epitope specific antibody.Type: GrantFiled: January 15, 2016Date of Patent: November 13, 2018Assignees: ChromoTek GmbH, NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Ulrich Rothbauer, Oliver Poetz, Tina Romer, Andrea Buchfellner, Larisa Yurlova, Kourosh Zolghadr, Jaqueline Bogner, Benjamin Ruf
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Publication number: 20170138927Abstract: In a method for automated determination of the relative position (x/y/z) between a first hole (27) on a first microsystem component (11), which is preferably provided with a first channel (44) opening in the first hole (27), and at least one second hole (29) on a second microsystem component (12), which is preferably provided with a second channel (45) opening in the second hole (29), the two microsystem components (11, 12) lie in a liquid medium (41) at least in the region (25, 26) of the holes (27, 29). Under the supervision of a control device (15) controlled by a computer (22), the first and second microsystem components (11, 12) are displaced relative to one another into different relative positions (x/y/z). Electrical signals (37) are delivered to one of the two microsystem components (12, 12) and are recorded on the other of the two microsystem components (11, 12) as measurement values (38) which depend on the relative position of the two microsystem components (11, 12) with respect to one another.Type: ApplicationFiled: February 1, 2017Publication date: May 18, 2017Applicant: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Timm DANKER, Elke GUENTHER
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Patent number: 8241894Abstract: A method for analyzing proteins makes use of an array of first capture molecules which are specific for peptide epitopes. The proteins to be analyzed or a protein mixture containing the proteins to be analyzed is degraded to peptide fragments corresponding to the peptide epitopes, after which the array of capture molecules is incubated with the peptide fragments. The peptide fragments bound to the capture molecules are then detected.Type: GrantFiled: December 1, 2010Date of Patent: August 14, 2012Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Thomas Joos, Dieter Stoll
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Publication number: 20110129943Abstract: A method for analyzing proteins makes use of an array of first capture molecules which are specific for peptide epitopes. The proteins to be analyzed or a protein mixture containing the proteins to be analyzed is degraded to peptide fragments corresponding to the peptide epitopes, after which the array of capture molecules is incubated with the peptide fragments. The peptide fragments bound to the capture molecules are then detected.Type: ApplicationFiled: December 1, 2010Publication date: June 2, 2011Applicant: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Thomas Joos, Dieter Stoll
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Patent number: 7867755Abstract: A method for analyzing proteins makes use of an array of first capture molecules which are specific for peptide epitopes. The proteins to be analyzed or a protein mixture containing the proteins to be analyzed is degraded to peptide fragments corresponding to the peptide epitopes, after which the array of capture molecules is incubated with the peptide fragments. The peptide fragments bound to the capture molecules are then detected.Type: GrantFiled: April 29, 2003Date of Patent: January 11, 2011Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TübingenInventors: Thomas Joos, Dieter Stoll
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Publication number: 20070218546Abstract: The invention relates to a method for coating a support plate for carrying out functional tests on biological cells, to a support plate for carrying out functional tests on biological cells and to the use of corresponding support plates for carrying out functional tests on biological cells.Type: ApplicationFiled: February 9, 2007Publication date: September 20, 2007Applicant: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat TubingenInventors: Heiko Steuer, Markus Templin, Britta Kanzok, Cornelia Kuschel, Brigitte Angres
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Patent number: 6989089Abstract: A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.Type: GrantFiled: October 26, 2001Date of Patent: January 24, 2006Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat Tubingen in ReutlingenInventors: Wilfried Nisch, Alfred Stett, Ulrich Egert, Martin Stelzle
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Patent number: 6984297Abstract: A method and a device are used for carrying out measurements on cells located in a liquid environment. Each cell is positioned with an underside of its membrane on a surface having a channel running through it. A negative pressure is established to aspirate the cells. Each cell is electrically scanned via at least one electrode which is spaced apart from the cell. The negative pressure is preferably established in a pulse-like manner to rupture the membrane in such a way that the cell interior enclosed by the membrane is connected to the channel.Type: GrantFiled: November 20, 2002Date of Patent: January 10, 2006Assignees: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Bayer AGInventors: Wilfried Nisch, Martin Stelzle, Alfred Stett, Thomas Krahn, Thomas Müller, Christoph Methfessel
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Patent number: 6315940Abstract: A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.Type: GrantFiled: May 13, 1999Date of Patent: November 13, 2001Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat Tubingen in ReutlingenInventors: Wilfried Nisch, Alfred Stett, Ulrich Egert, Martin Stelzle