Abstract: A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

Abstract: A method and a device are used for carrying out measurements on cells located in a liquid environment. Each cell is positioned with an underside of its membrane on a surface having a channel running through it. A negative pressure is established to aspirate the cells. Each cell is electrically scanned via at least one electrode which is spaced apart from the cell. The negative pressure is preferably established in a pulse-like manner to rupture the membrane in such a way that the cell interior enclosed by the membrane is connected to the channel.

Abstract: A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

Abstract: The invention concerns a microelectrode arrangement for leaking, with local resolution, electrical cell potentials, or for electrical stimulation of networks of biological cells such as for example cell cultures, tissue slices "in vitro" or biological tissue "in vivo". In order to attain high local resolution and high temporal resolution, the invention suggests that, as microelectrodes (M.sub.1 to M.sub.n), in each instance a contacting electrode (K.sub.1 to K.sub.n) be placed above a pad electrode (A.sub.1 to A.sub.n) onto a substrate (S); with light-sensitive elements, preferably in the shape of a continuous layer (P) arranged between the said contacting electrodes and the pad electrodes. By illuminating the light-sensitive layer (P) in the region of individual microelectrodes (M.sub.1 to M.sub.n), these microelectrodes are selected. Selection is preferably by the transmitted-light process through the substrate (S). In this case, substrate (S) and pad electrodes (A.sub.1 to A.sub.n) must be translucent.