Abstract: The subject invention relates to a genetically modified microorganism comprising a (R)-3-hydroxybutyric acid pathway and being able of producing (R)-3-hydroxybutyric acid, and a method of preparing (R)-3-hydroxybutyric acid or a salt thereof using the genetically modified microorganism.

Abstract: The present application discloses a method for preparing deuterium depleted water, wherein natural water is fed into the device of the present disclosure, and the liquid phase stream continuously flows backwards stage by stage under the combined action of the low-pressure steam compressors and the stream delivery pumps. In a single-stage system, the deuterium is deprived depending on the difference in vapor pressure between 1H2O and 2H2O (and/or 1H2HO), and finally, the deuterium depleted water is produced.

Abstract: The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.

Abstract: The present application discloses a device for multistage continuous preparation of deuterium depleted water, which includes a feeding pump, a plurality of stages of separation systems connected in series, and a receiver, all of which are connected in sequence. Each stage of separation system comprises a distillation column, a vapor-liquid separator, a low-pressure steam compressor, a stream delivery pump, a three-way valve, and a stream output pipe. The present application further discloses a method for preparing deuterium depleted water, wherein natural water is fed into the device of the present disclosure, and the liquid phase stream continuously flows backwards stage by stage under the combined action of the low-pressure steam compressors and the stream delivery pumps. In a single-stage system, the deuterium is deprived depending on the difference in vapor pressure between 1H2O and 2H2O (and/or 1H2HO), and finally, the deuterium depleted water is produced.

Abstract: The present application discloses a device for multistage continuous preparation of deuterium depleted water, which includes a feeding pump, a plurality of stages of separation systems connected in series, and a receiver, all of which are connected in sequence. Each stage of separation system comprises a distillation column, a vapor-liquid separator, a low-pressure steam compressor, a stream delivery pump, a three-way valve, and a stream output pipe. The present application further discloses a method for preparing deuterium depleted water, wherein natural water is fed into the device of the present disclosure, and the liquid phase stream continuously flows backwards stage by stage under the combined action of the low-pressure steam compressors and the stream delivery pumps. In a single-stage system, the deuterium is deprived depending on the difference in vapor pressure between 1H2O and 2H2O (and/or 1H2HO), and finally, the deuterium depleted water is produced.

Abstract: The present application discloses a device for multistage continuous preparation of deuterium depleted water, which includes a feeding pump, a plurality of stages of separation systems connected in series, and a receiver, all of which are connected in sequence. Each stage of separation system comprises a distillation column, a vapor-liquid separator, a low-pressure steam compressor, a stream delivery pump, a three-way valve, and a stream output pipe. The present application further discloses a method for preparing deuterium depleted water, wherein natural water is fed into the device of the present disclosure, and the liquid phase stream continuously flows backwards stage by stage under the combined action of the low-pressure steam compressors and the stream delivery pumps. In a single-stage system, the deuterium is deprived depending on the difference in vapor pressure between 1H2O and 2H2O (and/or 1H2HO), and finally, the deuterium depleted water is produced.

Abstract: The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.

Abstract: The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.