Abstract: Disclosed herein are portable gas delivery systems and therapeutic methods of use. More specifically, the portable gas delivery systems herein include a regulator having an inhalation device, such as a mouthpiece, and is configured to operably couple with removable sealed gas cartridges that comprise a therapeutic gas mixture of either one or more noble gases or nitrous oxide.

Abstract: The invention provides compositions, treatment means and protocols for induction of protective effects of organ grafts by administration of Dexmedetomidine, in combination with/without xenon or argon, in the conventional organ graft preservation solution storage solution. In one particular embodiment, the invention provides the activation of molecular pathways associated with reduction of oxidative stress and inhibition of regulated necrosis.

Abstract: Described are compositions of matter and protocols useful for treatment of neurological and other disorders associated with inflammatory activities. In some embodiments the invention provides means of modulating neuroinflammation through administration of noble gas containing compositions. In other aspects, the invention provides means of modulating stem cell compartments to enhance endogenous reparative activities or to synergize with existing treatments.

Abstract: Disclosed are compositions of matter, treatment methods, and combination therapies for addressing panic attacks in patients suffering from Panic Disorder (PD). In one embodiment the invention provides the use of Noble Gas containing mixtures at a sufficient concentration and frequency to prevent, and/or inhibit frequency of panic attacks. In one particular embodiment xenon gas is administered by inhalation of xenon-oxygen mixtures at concentrations ranging from 15%/85% to 30%/70% with xenon consumption is capped at 3.0 liters per procedure. In other embodiments xenon-oxygen or xenon-oxygen-nitrogen mixtures are administered at sub-anesthetic concentrations which are sufficient to elicit reduction in panic attacks and/or synergize with medications patients are receiving for panic/anxiety symptoms.

Abstract: Disclosed are means of preventing, reducing and/or treating pregnancy associated complications by administration of Noble Gas mixtures, directly by inhalation, or by other means of direct or indirect introduction, with the intended effect of reducing immunological/inflammatory events associated with said complications. In one embodiment the invention teaches the modulation of the maternal-fetal unit from a Th1/Th17 predisposition towards a Th2/Treg environment by inhalation of a combination of 30% xenon gas admixed with air, or combinations of medical grade oxygen and nitrogen.

Abstract: Disclosed are methods of inhibiting progression, stabilizing and reversing amyotrophic lateral sclerosis and neuromuscular degenerative diseases including spinal muscular atrophy, by administration of xenon, or noble gas compositions at a sufficient frequency and concentration to evoke anti-inflammatory, immunomodulatory, and regenerative processes in a patient in need of therapy. In one embodiment, xenon is administered as a pharmaceutical preparation at a concentration of 5 to 90% by volume, more preferably for certain embodiments, at 5 to 30% by volume, wherein said pharmaceutical preparation additionally contains oxygen, argon, nitrogen and/or air. In other embodiments argon is utilized together, or as a replacement for xenon. Furthermore, the use of xenon and/or other noble gas combinations are disclosed for augmentation of therapies that augment endogenous regenerative cells.

Abstract: The invention provides compositions, treatment means and protocols for induction of regenerative processes by administration of noble gases. In one particular embodiment the invention provides the stimulation of production of factors associated with augmentation of hematopoiesis, angiogenesis, and wound healing by exposure of cells, organs, or mammals to a noble gas. In a particular embodiment the invention provides the administration of argon as a noble gas capable of upregulating production of VEGF and angiopoietin.

Abstract: The invention discloses means of utilizing Noble Gases for inhibition of pathogenic processes associated with Alzheimer's Disease progression, as well as reversal of Alzheimer's Disease. In one embodiment compositions containing xenon gas are administered alone or together with therapeutic interventions for treatment of Alzheimer's Disease. In another embodiment, taupathies such as chronic traumatic encephalopathy are treated by administration of xenon or Noble Gas containing mixtures.

Abstract: Described are compositions of matter and protocols useful for treatment of neurological and other disorders associated with inflammatory activities. In some embodiments the invention provides means of modulating neuroinflammation through administration of noble gas containing compositions. In other aspects, the invention provides means of modulating stem cell compartments to enhance endogenous reparative activities or to synergize with existing treatments.

Abstract: Disclosed herein are portable gas delivery systems and therapeutic methods of use. More specifically, the portable gas delivery systems herein include a regulator having an inhalation device, such as a mouthpiece, and is configured to operably couple with removable sealed gas cartridges that comprise a therapeutic gas mixture of either one or more noble gases or nitrous oxide.

Abstract: Disclosed are methods, means and compositions of matter useful for improving outcomes after surgical interventions, said improvements including reduction of pain, acceleration of healing, reduction of fibrosis, inflammation and formation of surgical adhesions. Said surgical interventions include manipulation of tissues by means of mechanical, surgical, and ablative means. Said compositions include noble gases which directly or indirectly induce antifibrotic, anti-inflammatory and pain ameliorating effects. Said gases are injected directly during the procedure of tissue manipulation, or contacted with fluids, or fluids containing cells that are subsequently injected adjacent to said tissue being manipulated. In one embodiment of the invention, laparoscopic surgery is performed using noble gases to insufflate the said body cavities. In another embodiment, said noble gases are used to treat liquids added during said manipulations of tissue, including surgical manipulation.