Abstract: Systems and methods for treating a patient having symptoms of restless legs syndrome (RLS) or Periodic Limb Movement Disorder (PLMD) using high-frequency stimulation by applying a high-frequency pulsed electrostimulation therapy signal to a peroneal nerve or a branch thereof, where the therapy signal is above a motor threshold of a muscle innervated by the peroneal nerve or branch thereof. Surface EMG (sEMG) response to neurostimulation can be used to evaluate patient responsivity to neurostimulation, or to evaluate neurostimulation efficacy, such as to compare various neurostimulation parameter settings and to select between such settings to meet or balance between one or more goals. The sEMG response can be obtained with the muscle at rest, or during muscle activation.

Abstract: A system for monitoring or treating RLS or PLMD can include or use a leg-wearable electrostimulation device for acquiring auxiliary data from a subject at a first leg location at which the device is worn, the first leg-wearable electrostimulation device including or using a first neurostimulation delivery device, an impedance sensor configured for determining an impedance via the first and second skin electrodes, and an auxiliary sensor configured for detecting the auxiliary data of the first leg location at which the device is worn.

Abstract: Restless Leg Syndrome (RLS) or Periodic Limb Movement Disorder (PLMD) can be treated using high frequency (HF) electrostimulation. This can include selecting or receiving a subject presenting with RLS or PLMD. At least one electrostimulation electrode can be located at a location associated with at least one of, or at least one branch of, a sural nerve, a peroneal nerve, or a femoral nerve. HF electrostimulation can be delivered to the subject, which can include delivering subsensory, subthreshold, AC electrostimulation at a frequency that exceeds 500 Hz and is less than 15,000 Hz to the location to help reduce or alleviate the one or more symptoms associated with RLS or PLMD. A charge-balanced controlled-current HF electrostimulation waveform can be used.

Abstract: A transcutaneous neurostimulation therapy system can include an electrostimulation electronics unit, including first and second neurostimulation output which can be respectively coupled to first and second neurostimulation skin electrodes, and the electrostimulation electronics unit can include or be coupled to a rechargeable battery. The transcutaneous neurostimulation therapy system can also include battery charging circuitry configured for being coupled via the first and second neurostimulation output terminals to the electrostimulation electronics unit for charging the battery of the electrostimulation electronics unit through the first and second neurostimulation skin electrodes.

Abstract: Techniques to help improve efficiency or effectiveness of treating a disorder such as RLS or PLMD, such as by issuing neural electrostimulations to a particular patient, while varying one or more amplitude parameters (e.g., at least one of electrostimulation current amplitude, electrostimulation voltage amplitude, or electrostimulation pulsewidth duration). A corresponding patient-subjective or patient-objective response can be observed. A characteristic electrostimulation intensity relationship can be generated, for example, based on the determined respective at least one of RLS or PLMD response indication threshold amplitude parameters and the plurality of corresponding neural electrostimulation durations.

Abstract: Restless Leg Syndrome (RLS) or Periodic Limb Movement Disorder (PLMD) can be treated using high frequency (HF) electrostimulation. This can include selecting or receiving a subject presenting with RLS or PLMD. At least one electrostimulation electrode can be located at a location associated with at least one of, or at least one branch of, a sural nerve, a peroneal nerve, or a femoral nerve. HF electrostimulation can be delivered to the subject, which can include delivering subsensory, subthreshold, AC electrostimulation at a frequency that exceeds 500 Hz and is less than 15,000 Hz to the location to help reduce or alleviate the one or more symptoms associated with RLS or PLMD. A charge-balanced controlled-current HF electrostimulation waveform can be used.

Abstract: Systems and methods for treating a patient having symptoms of restless legs syndrome (RLS) or Periodic Limb Movement Disorder (PLMD) using high-frequency stimulation by applying a high-frequency pulsed electrostimulation therapy signal to a peroneal nerve or a branch thereof, where the therapy signal is above a motor threshold of a muscle innervated by the peroneal nerve or branch thereof. Surface EMG (sEMG) response to neurostimulation can be used to evaluate patient responsivity to neurostimulation, or to evaluate neurostimulation efficacy, such as to compare various neurostimulation parameter settings and to select between such settings to meet or balance between one or more goals. The sEMG response can be obtained with the muscle at rest, or during muscle activation.

Abstract: Restless Leg Syndrome (RLS) or Periodic Limb Movement Disorder (PLMD) can be treated using high frequency (HF) electrostimulation. This can include selecting or receiving a subject presenting with RLS or PLMD. At least one electrostimulation electrode can be located at a location associated with at least one of, or at least one branch of, a sural nerve, a peroneal nerve, or a femoral nerve. HF electrostimulation can be delivered to the subject, which can include delivering subsensory, subthreshold, AC electrostimulation at a frequency that exceeds 500 Hz and is less than 15,000 Hz to the location to help reduce or alleviate the one or more symptoms associated with RLS or PLMD. A charge-balanced controlled-current HF electrostimulation waveform can be used.