Patents Assigned to NOF Corporation
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Patent number: 8288498Abstract: A sugar-alcohol-modified organopolysiloxane compound represented by formula (1) and processes for producing the compound. (In the formula, R1 represents a hydrocarbon group having 1-8 carbon atoms; X is a group represented by formula (2); Y represents —R4O(AO)nR5 (wherein AO is an oxyalkylene group having 2-4 carbon atoms, R4 is a divalent hydrocarbon group having 3-5 carbon atoms, R5 is any of a hydrogen atom, a hydrocarbon group having 1-24 carbon atoms, and an acyl group having 2-24 carbon atoms, and n is 1-100); R2 is any of R1, X, and Y; and a is 0-700, b is 0-100, and c is 0-50; provided that when b is 0, at least one of the R2s is X.) (In the formula, R3 is a divalent hydrocarbon group having 3-5 carbon atoms; and d is 1-2.Type: GrantFiled: March 26, 2008Date of Patent: October 16, 2012Assignee: NOF CorporationInventors: Yoshihiro Hayashi, Satoshi Abe
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Publication number: 20120258165Abstract: A phospholipid derivative represented by the following formula (1) wherein each symbol is as described in the specification; a liposome containing the phospholipid derivative, and the like.Type: ApplicationFiled: November 12, 2010Publication date: October 11, 2012Applicants: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION, NOF CORPORATIONInventors: Masaya Arai, Kazuhiro Kubo, Shoichi Yokoyama, Kenji Kono
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Patent number: 8282938Abstract: The present invention provides an avian influenza vaccine containing a peptide-bound liposome wherein; the peptide contains: (1) an amino acid sequence shown by any one of SEQ ID NO:1 to 9, or (2) an amino acid sequence shown by any one of SEQ ID NO:1 to 9 wherein one or two amino acids are substituted, has a length of 9 to 11 amino acids, and is capable of inducing HLA-restricted cytotoxic T lymphocytes; wherein the liposome contains a phospholipid having an acyl group with 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group with 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer; and wherein the peptide is bound to the surface of the liposome.Type: GrantFiled: March 9, 2009Date of Patent: October 9, 2012Assignees: National Institute of Infectious Diseases, National University Corporation Hokkaido University, Saitama Medical University, NOF CorporationInventors: Tetsuya Uchida, Maiko Taneichi, Kiichi Kajino, Masanori Matsui, Hiroshi Oda
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Publication number: 20120253053Abstract: Provided are a thiol-reactive polyoxyalkylene-modified lipid which can be used to chemically modify bioactive substances and which can be used for drug delivery systems such as liposomes and a method for producing the same. The polyoxyalkylene-modified lipid is represented by the following formula (1): (wherein, R1 and R2 are hydrocarbon groups which are the same as or different from each other and which contain 4 to 24 carbon atoms, R3 is a divalent hydrocarbon group containing 1 to 6 carbon atoms, OA is oxyalkylene groups containing 2 to 4 carbon atoms, n is the average addition mole number of the oxyalkylene groups and is 5 to 1,000, and Z is a group containing either maleimide or iodoacetamide.Type: ApplicationFiled: March 27, 2012Publication date: October 4, 2012Applicant: NOF CORPORATIONInventors: Matsuo Satoshi, Yuji Yamamoto, Chika Itoh
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Patent number: 8278097Abstract: The invention relates to a vessel for embryoid formation used for forming embryoid bodies from ES cells easily without complicated technique, and to a method for forming embryoid bodies easily and efficiently using the vessel. The method includes the steps of (A) providing a vessel for embryoid formation having a coating layer formed from a compound having a particular PC-like group on a vessel surface defining a region for floating culture of ES cells, and (B) floating culturing ES cells in the vessel to form embryoid bodies.Type: GrantFiled: June 8, 2009Date of Patent: October 2, 2012Assignee: NOF CorporationInventors: Hiroshi Kurosawa, Shujiro Sakaki
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Publication number: 20120245250Abstract: Provided is an anti-fog coating composition that rarely suffers from blushing when applied and dried even under high-humidity conditions and that can be heat-cured even at low temperature in a short time and form a coating film that exhibits excellent tight adhesion to a substrate and excellent heat resistance and anti-fog properties. The anti-fog coating composition comprises (A) a copolymer prepared from a monomer mixture of a monomer (A1), a monomer (A2) and a monomer (A3); (B) a basic compound such as amines; and (C) a surfactant such as anionic surfactants. The monomer (A1) is a vinyl monomer that has an N-methylol group or an N-alkoxymethylol group. The monomer (A2) is a vinyl monomer that has a sulfonic acid group. The monomer (A3) is an alkyl(meth)acrylate monomer.Type: ApplicationFiled: December 21, 2010Publication date: September 27, 2012Applicant: NOF CORPORATIONInventors: Takamitsu Kano, Shinji Mashiko, Takuro Makiguchi, Michihisa Yamada
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Publication number: 20120237569Abstract: Provided is an emulsified composition for diluting a cancer antigen peptide or a dimer thereof. Also provided is a novel cancer vaccine composition or specific CTL inducer that efficiently induces CTL irrespective of the type of cancer antigen peptide when mixing the emulsified composition for dilution and a water phase comprising a cancer antigen peptide or a dimer thereof. The present invention relates to an emulsified composition for diluting a cancer antigen peptide or a dimer thereof, comprising a particular ester, a particular surfactant, a particular emulsifier, and a water phase. The present invention also relates to a cancer vaccine composition or specific CTL inducer obtained by freshly diluting and mixing a water phase comprising a cancer antigen peptide or a dimer thereof with the emulsified composition for dilution.Type: ApplicationFiled: March 28, 2012Publication date: September 20, 2012Applicants: NOF CORPORATION, DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Koichi SAITO, Yusuke OKAWA
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Patent number: 8263405Abstract: To provide a new reductive-stimuli-responsive degradable gel that allows any control of decomposition of the three-dimensional base material for cell culture and production of a completely biological three-dimensional cellular structure consisting only of cells and cells-produced extracellular matrix and that allows safe recovery of the cellular structure produced. A stimuli-responsive hydrogel, characterized by being produced by crosslinking a water-soluble polymer with a compound having a disulfide bond in the molecular chain.Type: GrantFiled: November 24, 2006Date of Patent: September 11, 2012Assignees: NOF CorporationInventors: Mitsuru Akashi, Yoshiki Sawa, Michiya Matsusaki
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Patent number: 8252531Abstract: The present invention relates to an inhibitor capable of increasing accuracy of the reaction in hybridization, and inhibiting nonspecific hybridization, a clinical diagnostic reagent, and a method of clinical analysis whereby nonspecific hybridization in clinical analysis is inhibited, and a target nucleic substance is detected easily with high accuracy. The inhibitor and the clinical diagnostic reagent contains polymer (H) having a nonspecific hybridization inhibitory action. The polymer has in its molecule at least one of carboxyl and sulfone groups, and phosphorylcholine-like groups, and has a weight average molecular weight of 1000 to 5000000. The method of clinical analysis includes contacting a sample with a test agent capable of hybridizing with a specific nucleic substance in the presence of the inhibitor.Type: GrantFiled: April 25, 2002Date of Patent: August 28, 2012Assignee: NOF CorporationInventors: Shujiro Sakaki, Kenshiro Shuto, Mamoru Tsuchida, Yoshihiro Ashihara, Mitsuo Isomura
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Patent number: 8232321Abstract: The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z—{O-[(AO)a-(EO)b]-R}2??(I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1?2 a?150 and 1?2 b?150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %.Type: GrantFiled: July 25, 2008Date of Patent: July 31, 2012Assignees: Shiseido Company, Ltd., NOF CorporationInventors: Takashi Ohmori, Akira Ishikubo, Yuki Sugiyama, Yuko Matsui, Tomoyuki Kawasoe, Yoji Tezuka, Hiroyasu Mizuno, Kei-ichi Maruyama
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Patent number: 8178102Abstract: Provided is an emulsified composition for diluting a cancer antigen peptide or a dimer thereof. Also provided is a novel cancer vaccine composition or specific CTL inducer that efficiently induces CTL irrespective of the type of cancer antigen peptide when mixing the emulsified composition for dilution and a water phase comprising a cancer antigen peptide or a dimer thereof. The present invention relates to an emulsified composition for diluting a cancer antigen peptide or a dimer thereof, comprising a particular ester, a particular surfactant, a particular emulsifier, and a water phase. The present invention also relates to a cancer vaccine composition or specific CTL inducer obtained by freshly diluting and mixing a water phase comprising a cancer antigen peptide or a dimer thereof with the emulsified composition for dilution.Type: GrantFiled: January 19, 2006Date of Patent: May 15, 2012Assignees: Dainippon Sumitomo Pharma Co., Ltd., NOF CorporationInventors: Koichi Saito, Yusuke Okawa
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Publication number: 20120097169Abstract: Disclosed is a respiration-assisting tube whereby tissue damages in vivo can be prevented and, as a result, inflammatory reactions and infections can be avoided. The respiration-assisting tube is developed based on the finding that adhesion of cells to a respiration-assisting tube can be inhibited by coating the respiration-assisting tube with a polymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC). Also, the respiration-assisting tube is developed based on the finding that, by coating a respiration-assisting tube with a polymer containing MPC, mucosa peeling and tissue damages, which occur after using the respiration-assisting tube, can be prevented and, as a result, inflammatory reactions can be avoided.Type: ApplicationFiled: April 26, 2010Publication date: April 26, 2012Applicants: Next21 K.K., NOF Corporation, The University of TokyoInventors: Yuichi Tei, Nobuo Sasaki, Shigeki Suzuki
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Patent number: 8163869Abstract: An object of the present invention is to provide a purification method of separating impurities from a carboxyl group-containing polyoxyethylene derivative having a molecular weight of 2,000 to 100,000. The purification method according to the invention includes the following steps. The polyoxyethylene derivative is dissolved to form a solution using toluene, xylene, benzene, ethyl acetate, or butyl acetate in an amount 5 times by mass or more the amount of the polyoxyethylene derivative. A slurry is formed by adding to the solution an inorganic adsorbent containing at least one of an oxide and a hydroxide of one or more elements selected from the group consisting of magnesium, silicon, and aluminum in an amount 0.5 to 10 times by mass the amount of the polyoxyethylene derivative. The slurry is stirred at a temperature of 25° C. or higher. Toluene, xylene, benzene, ethyl acetate, or butyl acetate is added to a filtration cake obtained by filtration of the slurry, and further filtration is performed.Type: GrantFiled: December 27, 2010Date of Patent: April 24, 2012Assignee: NOF CorporationInventors: Shuichi Yoshimura, Ken-ichiro Nakamoto, Satoshi Matsuo, Takashi Ichikawa
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Patent number: 8153142Abstract: A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O-[(AO)m(EO)n]—R2??(I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1?m?70 and 1?n?70 respectively, wherein EO is 20˜80% by weight with respect to a total of AO and EO; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.Type: GrantFiled: August 11, 2009Date of Patent: April 10, 2012Assignees: Shiseido Co., Ltd., NOF CorporationInventors: Takashi Ohmori, Tohru Okamoto, Hiroyuki Kakoki, Reji Miyahara, Tomiyuki Nanba, Toshihiko Nakane, Yohei Hamano, Eriko Takeoka
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Publication number: 20120077988Abstract: A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20?n?2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.Type: ApplicationFiled: June 24, 2011Publication date: March 29, 2012Applicant: NOF CORPORATIONInventors: Yuji Yamamoto, Hiroki Yoshioka, Fumiaki Manabe
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Patent number: 8143327Abstract: A core-shell fine particle (10) is produced as follows. First of all, a monomer mixture containing 15-99% by mass of a crosslinkable monomer and 1-85% by mass of a monomer having an ATRP initiating group is adsorbed into an organic monodispersed seed particle. Next, the monomer mixture is polymerized by a polymerization initiator, thereby forming a core layer composed of a monodispersed crosslinked fine particle (11) containing an ATRP initiating group (12). A shell layer (13) is then formed by graft polymerizing a monomer onto the thus-obtained core layer.Type: GrantFiled: April 15, 2008Date of Patent: March 27, 2012Assignee: NOF CorporationInventors: Masaki Hayashi, Masumi Takamura
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Patent number: 8114930Abstract: An anti-adhesion agent composition for asphalt contains a specific polycarboxylic acid compound (A); a surfactant (B) that is at least one selected from a betaine amphoteric surfactant, an amino acid amphoteric surfactant, a polyoxyethylene alkylamine surfactant, an alkanolamide surfactant, and an amine oxide surfactant; and a water-soluble polyhydric alcohol (C).Type: GrantFiled: August 16, 2010Date of Patent: February 14, 2012Assignee: NOF CorporationInventors: Motonari Mizuta, Ebana Hiroatsu
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Patent number: 8097692Abstract: A purification method in which, from a specific polyoxyalkylene derivative having a molecular weight of 8,800 to 100,000, an impurity differing in the number of hydroxyl groups is separated, the method including steps (A), (B), (C), and (D). Step (A): a step in which an aprotic organic solvent is used in an amount at least 5 times by weight the amount of the polyoxyalkylene derivative to dissolve the polyoxyalkylene derivative therein and give a solution; step (B): a step in which an adsorbent comprising an oxide containing at least one of aluminum and silicon is added to the solution in an amount 0.5 to 5 times by weight the amount of the polyoxyalkylene derivative to thereby yield a slurry; step (C): a step in which the slurry is stirred at 25° C. or higher; step (D): a step in which the polyoxyalkylene derivative is recovered from the slurry.Type: GrantFiled: March 31, 2010Date of Patent: January 17, 2012Assignee: NOF CorporationInventors: Shuichi Yoshimura, Ken-ichiro Nakamoto, Chika Itoh
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Publication number: 20110319583Abstract: The invention provides a silicone monomer which is suitable for the manufacture of ophthalmic devices, such as contact lenses, intraocular lenses, and keratoprosthesis, a monomer composition containing the monomer, and a polymer which fulfills both surface hydrophilicity and oxygen permeability at the same time. The silicone monomer of the present invention is represented by the formula (1a) or (1b): (X: a monovalent C2 to C6 organic group having one or more —OH and optionally one 0 or N in its main chain; Z1 to Z9: a C1 to C4 alkyl group; n: 1 to 3; a and b: 0 or 1).Type: ApplicationFiled: March 5, 2010Publication date: December 29, 2011Applicant: NOF CORPORATIONInventors: Yosuke Matsuoka, Nobuyuki Yoshioka, Mao Sorimachi
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Patent number: 8071712Abstract: An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded. The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A).Type: GrantFiled: February 28, 2008Date of Patent: December 6, 2011Assignee: NOF CorporationInventors: Kenji Sakanoue, Hiroki Yoshioka, Tomohiro Shirosaki