Abstract: A method of recovering a highly pure hydrocodone base from an impure hydrocodone preparation includes contacting the impure hydrocodone preparation with a weak acid in water to form a solution and adding a strong base to the solution in an amount sufficient to precipitate the pure hydrocodone base product. A highly pure hydrocodone base comprises less than 0.0025 wt % codeinone.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
October 26, 2021
Assignee:
NORAMCO, LLC
Inventors:
Jessica Cardot, Joshua Sasine, Paul Nichols
Abstract: The present disclosure relates to the preparation of methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate (ITE) and related compounds with high yield, purity, and scalability. The processes apply the use of a Weinreb amide intermediate as a scaffold for the preparation of ITE and structural analogs.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
October 5, 2021
Assignee:
Noramco, LLC
Inventors:
Martin Benedict Strack, Jasper Kaiser, Gnel Mkrtchyan, Wen-Chun Zhang
Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.
Type:
Grant
Filed:
April 21, 2017
Date of Patent:
April 21, 2020
Assignee:
Noramco, LLC
Inventors:
Dominique Roberge, Petteri Elsner, Christian Oliver Kappe, Bernhard Gutmann, Ulrich Weigl, Douglas Phillip Cox