Patents Assigned to Nordion (Canada) Inc.
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Patent number: 9133208Abstract: The present application discloses a compound of formula (I) or (II): wherein X is gamma-emitting radionuclide. Also disclosed is a pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof, and a physiologically acceptable vehicle and a method of imaging a region in a patient, which includes administering to the patient a diagnostically effective amount of the pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof.Type: GrantFiled: July 13, 2012Date of Patent: September 15, 2015Assignee: NORDION (CANADA) INC.Inventors: Lihui Wei, Xuxu Yan, Corinne Bensimon, Terrence David Ruddy
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Publication number: 20140231654Abstract: A radiation detector that can be used to detect the intensity of radiation fields and provide feedback to the user about the location of radiation fields. The radiation detector has a number of radiation detection volumes that are arranged in a staggered pattern relative to a sweeping direction of the radiation detector. The staggered arrangement of the detection volumes allows a large gap-free detection volume that is composed of smaller detection volumes in order to provide adequate sensitivity.Type: ApplicationFiled: September 30, 2013Publication date: August 21, 2014Applicant: NORDION (Canada) Inc.Inventors: PETER REID, NIGEL VEZEAU
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Patent number: 8772446Abstract: A bifunctional chelating agent of the formula (I): wherein the variables R1, R1?, Q1, Q2 and M are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a stable or radioactive metal; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate.Type: GrantFiled: February 18, 2011Date of Patent: July 8, 2014Assignee: Nordion (Canada) Inc.Inventors: Mike Adam, Eszter Boros, Cara L. Ferreira, Chris Orvig, Eric William Price
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Publication number: 20130220928Abstract: A method of treating an adsorbent for a chromatographic separation. The method involves sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide and washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter to produce a treated adsorbent. The treated adsorbent can be used in a method of isolating a daughter radioisotope from a daughter radioisotope that is produced from the parent radioisotope by radioactive decay.Type: ApplicationFiled: December 7, 2012Publication date: August 29, 2013Applicant: Nordion (Canada) Inc.Inventor: Nordion (Canada) Inc.
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Patent number: 8518715Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.Type: GrantFiled: May 21, 2012Date of Patent: August 27, 2013Assignee: Nordion (Canada) Inc.Inventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso, Cara Ferreira
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Publication number: 20130022542Abstract: The present application discloses a compound of formula (I) or (II): wherein X is gamma-emitting radionuclide. Also disclosed is a pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof, and a physiologically acceptable vehicle and a method of imaging a region in a patient, which includes administering to the patient a diagnostically effective amount of the pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof.Type: ApplicationFiled: July 13, 2012Publication date: January 24, 2013Applicant: NORDION (CANADA) INC.Inventors: Lihui WEI, Xuxu Yan, Corinne Bensimon, Terrence David Ruddy
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Publication number: 20120276001Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.Type: ApplicationFiled: May 21, 2012Publication date: November 1, 2012Applicant: Nordion (Canada) IncInventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso, Cara Ferreira
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Patent number: 8198101Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.Type: GrantFiled: March 6, 2007Date of Patent: June 12, 2012Assignee: Nordion (Canada) Inc.Inventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso
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Publication number: 20120095185Abstract: An isolated conformational isomer of a bifunctional chelating agent of the formula (I): wherein the variables Q1 and Q2 are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a stable or radioactive metal; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate.Type: ApplicationFiled: September 20, 2011Publication date: April 19, 2012Applicant: NORDION (CANADA) INC.Inventors: Garry E. KIEFER, Cara L. Ferreira, Paul Jurek
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Publication number: 20120053554Abstract: The present invention relates to a method for increasing leakage resistance in a closed, pressurized system. The method involves providing a closed system including a container sealed with a septum having a top surface with an exposed section, which is maintained under a positive pressure of at least about 5 psig. A contact surface of a hard component is fixedly placed adjacent to or in contact with at least a portion of a border section or a central section of the exposed section of the septum, or both, to reduce the size of any bulge or deformation formed in the exposed section of the septum. The present invention also relates to a kit for increasing leakage resistance in a closed, pressurized system, which includes the hard component.Type: ApplicationFiled: December 8, 2009Publication date: March 1, 2012Applicant: NORDION (CANADA) INC.Inventors: Thomas J. Simpson, Graham Duncan, Donald Scott