Abstract: Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5.alpha.-reductase enzyme inhibitor and an androgen receptor blocking agent in a pharmaceutically and dermatologically acceptable vehicle. The compositions may be topically applied to affected areas of the skin in the treatment or prevention of sebaceous gland hypertrophy, hirsutism and male-pattern baldness in mammals. The inhibitor and blocking agent are present in the composition in a weight ratio of about 1:20 to 5:1, with the inhibitor comprising up to about 0.1% w/v of the comopsition and the blocking agent comprising up to about 1% w/v of the composition.

Abstract: A carpule system for the microadministration of viscous fluid including a carpule syringe comprising a stainless steel delivery needle having an interior diameter in the range of from about 0.004 inches to about 0.007 inches and a generally cylindrical fluid containing carpule. The carpule has a bore with a cross-sectional area which is about 100 to 400 times greater than the cross-sectional area of the bore of the delivery needle and a movable plug sealing the fluid within the carpule. The needle is secured to one end of the carpule and a generally cylindrical housing member is adapted to receive the carpule, the housing member having means on one end for retaining the one end of the carpule. An adapter member is secured to the other end of the housing member to secure the other end of the carpule and adapter retention means are provided for securing the adapter member to the other end of the housing member.

Abstract: Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5.alpha.-reductase enzyme inhibitor and an androgen receptor blocking agent in a pharmaceutically and dermatologically acceptable vehicle. The compositions may be topically applied to affected areas of the skin in the treatment or prevention of sebaceous gland hypertrophy, hirsutism and male-pattern baldness in mammals. The inhibitor and blocking agent are present in the composition in a weight ratio of about 1:20 to 5:1, with the inhibitor comprising up to about 0.1% w/v of the composition and the blocking agent comprising up to about 1% w/v of the composition.

Abstract: The present invention provides a syringe for the administration of small amounts of high viscosity fluid having a barrel and a delivery needle having substantially the same inside diameter. It is preferred that the barrel comprise a stainless steel tube. A generally cylindrical housing member having openings at each end of the housing and threads on one end for attaching the housing member to the barrel. An adapter member, secured to the other end of the housing member, receives and supports the other end of the barrel. A cap secures the adapter member to the other end of the housing member. A plunger is adapted for axial displacement within the barrel, and has a plunger tip which is chemically inert with respect to the fluid and which is adapted to slidingly engage the interior surface of the barrel and to seal the fluid within the barrel. A finger grip and a thumb grip facilitate movement of the plunger relative to the barrel.