Patents Assigned to NormOxys, Inc.
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Publication number: 20160120887Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.Type: ApplicationFiled: December 13, 2013Publication date: May 5, 2016Applicant: NormOxys, Inc.Inventors: Claude Nicolau, Jean-Marie Lehn
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Publication number: 20160067267Abstract: The present invention provides for novel treatments of obesity and overweight and related disorders. The invention provides, in part, method of treatment comprising, or uses of inositol-tripyrophosphate (ITPP) in these disease states.Type: ApplicationFiled: March 14, 2014Publication date: March 10, 2016Applicant: NormOxys, Inc.Inventors: Ruth Greferath, Jean-Marie Lehn, Yves Claude Nicolau
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Patent number: 9078908Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.Type: GrantFiled: June 20, 2013Date of Patent: July 14, 2015Assignee: NormOxys, Inc.Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
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Publication number: 20140199261Abstract: Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders.Type: ApplicationFiled: July 25, 2013Publication date: July 17, 2014Applicants: Universite de Strasbourg, NormOxys, Inc.Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Claudine Kieda
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Publication number: 20140194391Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.Type: ApplicationFiled: November 8, 2013Publication date: July 10, 2014Applicants: Universite de Strasbourg, NormOxys, Inc.Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
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Publication number: 20140179635Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.Type: ApplicationFiled: December 13, 2013Publication date: June 26, 2014Applicant: NormOxys, Inc.Inventors: Claude Nicolau, Jean-Marie Lehn
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Publication number: 20140171394Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.Type: ApplicationFiled: December 9, 2013Publication date: June 19, 2014Applicants: Universite de Strasbourg, NormOxys, Inc.Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
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Publication number: 20140155334Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.Type: ApplicationFiled: November 25, 2013Publication date: June 5, 2014Applicants: Université de Strasbourg, NormOxys, Inc.Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
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Publication number: 20140142052Abstract: The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.Type: ApplicationFiled: May 17, 2013Publication date: May 22, 2014Applicant: NormOxys, Inc.Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Srinivasu Pothukanuri, Adam Brockman, John Hey, Jeremy Yu
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Publication number: 20140088036Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.Type: ApplicationFiled: September 30, 2011Publication date: March 27, 2014Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.Inventors: Jean Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
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Publication number: 20130190524Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.Type: ApplicationFiled: August 22, 2012Publication date: July 25, 2013Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
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Publication number: 20130059820Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.Type: ApplicationFiled: March 21, 2012Publication date: March 7, 2013Applicant: NORMOXYS, INC.Inventors: Yves Claude NICOLAU, Jean-Marie LEHN, Konstantina FYLAKTAKIDOU, Ruth GREFERATH
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Patent number: 8178514Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.Type: GrantFiled: February 10, 2011Date of Patent: May 15, 2012Assignee: Normoxys, Inc.Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
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Publication number: 20120094961Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.Type: ApplicationFiled: September 28, 2011Publication date: April 19, 2012Applicant: Normoxys, Inc.Inventors: Claude NICOLAU, Jean-Marie Lehn
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Publication number: 20120010174Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.Type: ApplicationFiled: July 5, 2011Publication date: January 12, 2012Applicant: Normoxys, Inc.Inventors: Yves Claude NICOLAU, Jean-Marie Lehn, Konstantina C. Flyaktakidou, Ruth Greferath
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Publication number: 20120003161Abstract: Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.Type: ApplicationFiled: August 18, 2011Publication date: January 5, 2012Applicant: NORMOXYS, INC.Inventors: Claude Nicolau, Ruth Greferath, Konstantina C. Fylaktakidou, Jean-Marie Lehn
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Publication number: 20110294732Abstract: The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.Type: ApplicationFiled: July 5, 2011Publication date: December 1, 2011Applicants: Universite De Strasbourg, Normoxys, Inc.Inventors: Claude NICOLAU, Jean-Marie Lehn, Ruth Greferath
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Patent number: 7919481Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.Type: GrantFiled: December 23, 2009Date of Patent: April 5, 2011Assignee: NormOxys, Inc.Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Ruth Greferath
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Publication number: 20100267674Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.Type: ApplicationFiled: June 28, 2010Publication date: October 21, 2010Applicants: NORMOXYS, INC., UNIVERSITE DE STRASBOURGInventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
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Patent number: 7745423Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.Type: GrantFiled: May 30, 2008Date of Patent: June 29, 2010Assignees: NormOxys, Inc, Universite de StrasbourgInventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath