Abstract: The invention relates to indicator ink compositions that contain a water-based dispersion of a phenol-formaldehyde resin, at least one colorant and an amine-terminated catalyst. These indicator ink compositions are fixed to a surface, such as by drying, and respond to specific conditions of time, temperature, humidity, pressure and the presence or absence of certain chemicals by changing color. Compositions provide a means for detecting exposure to a predetermined condition and can be fixed or otherwise attached to nearly any article or designed into patterns on materials. Exposure of the indicator ink to the specific condition, the indicator ink provides a permanent detectable record of the event. Further, by varying the amount of amine-terminated catalyst in the formulation, the specific conditions at which the indicator composition will change color can be altered. Such compositions are specifically useful for determining the effectiveness of a sterilization process.

Abstract: This invention relates to novel apparatus and methods for inserting and positioning a compressible material into a container and for using the container for detecting a specific environmental parameter or combination of parameters, or for determining the effectiveness of a sterilization procedure. Precise positioning of a plug of compressible material in a container has been discovered to provide flexibility necessary for production of indicator systems that vary in their response to sterilizing conditions to reflect the efficacy of sterilizers based on different modes of sterilization and reproduceability necessary for accurate monitoring of each mode. The invention also relates to test indicators containing controlled volumes of compressed, gas-permeable materials and to methods for using test indicators for determining the efficacy of different types of sterilization processes. The test indicator consists of a plurality of interactive enzymes in a container with at least one opening.

Abstract: This invention relates to novel apparatus and methods for inserting and positioning a compressible material into a container and for using the container for detecting a specific environmental parameter or combination of parameters, or for determining the effectiveness of a sterilization procedure. Precise positioning of a plug of compressible material in a container has been discovered to provide flexibility necessary for production of indicator systems that vary in their response to sterilizing conditions to reflect the efficacy of sterilizers based on different modes of sterilization and reproduceability necessary for accurate monitoring of each mode. The invention also relates to test indicators containing controlled volumes of compressed, gas-permeable materials and to methods for using test indicators for determining the efficacy of different types of sterilization processes. The test indicator consists of a plurality of interactive enzymes in a container with at least one opening.

Abstract: The application discloses a test vial including a test article for immersion into a fluid medium, a sealed chamber which contains the fluid medium, and an open chamber which is external to the sealed chamber and which supports the test article. The sealed and open chambers define a barrier which isolates the fluid medium from the test article. The open chamber is covered by a closure. Retaining means are positioned on the closure and cooperatively support the closure in a first position and cooperatively receive the closure in a second position. The closure has a means for penetrating the barrier and for injecting the test article into the fluid medium when the closure is moved from the first position to the second position while maintaining the sealed chamber in a sealed condition upon movement of the closure from the first position to the second position.

Abstract: The application discloses a test vial including a test article for immersion into a fluid medium, a sealed chamber which contains the fluid medium, and an open chamber which is external to the sealed chamber and which supports the test article. The sealed and open chambers define a barrier which isolates the fluid medium from the test article. The open chamber is covered by a closure. Retaining means are positioned on the open chamber and on the closure. The retaining means cooperatively support the closure in a first position and cooperatively receive the closure in a second position. The closure has a means for detaching the barrier from the open and sealed chambers and for injecting the test article in the fluid medium when the closure is moved from the first position to the second position.