Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.
Type:
Grant
Filed:
October 14, 2011
Date of Patent:
July 24, 2018
Assignees:
RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE, NORTH CAROLINA AT CHAPEL HILL, UNIVERSITY OF