Patents Assigned to North Carolina State University
  • Publication number: 20220372492
    Abstract: Methods for treating diseases and conditions mediated by the high affinity IgE receptor (Fc?RI). Antisense oligomers for modulating splicing of mRNA encoding the Fc?RI? protein, thereby down-regulating cell-surface expression of Fc?RI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.
    Type: Application
    Filed: March 7, 2022
    Publication date: November 24, 2022
    Applicants: North Carolina State University, The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Glenn P. Cruse, Dean D. Metcalfe
  • Patent number: 11499948
    Abstract: Described herein are devices and methods of use thereof, the devices comprising: a sample conduit providing a path for fluid flow extending from a sample inlet to a sample outlet; a thermal housing enclosing the sample conduit, the thermal housing comprising a plurality of measurement regions; and a motorized stage translatable along the thermal housing so as to align a detector with one or more of the plurality of measurement regions. The devices can continuously flow a fluid precursor sample from the sample inlet to the sample outlet, the fluid precursor sample comprising a first precursor and a second precursor, such that the first precursor reacts with the second precursor as the fluid precursor sample continuously flows from the sample inlet to the sample outlet to form the sample before reaching the sample outlet, wherein the sample comprises a plurality of particles or an organic molecule.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: November 15, 2022
    Assignee: North Carolina State University
    Inventors: Milad Abolhasani, Robert W. Epps, Kobi C. Felton
  • Patent number: 11499169
    Abstract: The present invention is directed to methods and compositions for typing of Lactobacillus buchneri bacterial strains, detecting the presence of a L. buchneri in a sample, identifying a strain of L. buchneri having resistance to an invasive foreign genetic element, modifying the resistance of bacteria and archeae to an invasive foreign genetic element, and introducing nicks into or cleaving double stranded DNA for genome editing.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: November 15, 2022
    Assignee: North Carolina State University
    Inventors: Rodolphe Barrangou, Alexandra Briner Crawley
  • Publication number: 20220354081
    Abstract: Hybrid tomato varieties designated ‘VT19077208’ and ‘VT19108230’ are disclosed. ‘VT19077208’ and ‘VT19108230’ are hybrid tomato varieties exhibiting stability and uniformity.
    Type: Application
    Filed: April 5, 2022
    Publication date: November 10, 2022
    Applicants: VoloAgri Group, Inc., North Carolina State University
    Inventors: Lakhwinder RANDHAWA, Mario Velasco ALVARADO, Higinio MAYORQUIN
  • Patent number: 11486010
    Abstract: The present disclosure relates to high-throughput detection of polyketides using genetically encoded biosensors.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: November 1, 2022
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Gavin J. Williams, Christian Kasey, Yiwei Li
  • Patent number: 11484818
    Abstract: Various implementations include a self-cleaning screen device including a screen and auger. The screen is a hollow cylinder and has a screen central axis, a screen inner surface, a screen outer surface opposite and radially spaced apart from the screen inner surface, a screen first end, and a screen second end opposite and axially spaced apart from the screen first end. The screen outer surface defines a plurality of openings extending radially to the screen inner surface. The auger is helically shaped and has an auger central axis, an auger first end, and an auger second end opposite and axially spaced apart from the auger first end. The auger is disposed around at least a portion of the screen outer surface such that the auger central axis and the screen central axis are coincident with each other. The auger is rotatable about the auger central axis relative to the screen.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: November 1, 2022
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Francis L. De Los Reyes, III, Tate W. Rogers, Walter Beckwith
  • Patent number: 11487926
    Abstract: A system can include a nonlinear circuit and a voltage decoder. The nonlinear circuit can perform an operation on an input voltage. The operation can be changed. A voltage decoder can be communicatively coupled to the nonlinear circuit for receiving an output voltage from the nonlinear circuit that results from the operation performed on the input voltage. The voltage decoder can compare the output voltage to a threshold voltage and determine a result of the operation.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: November 1, 2022
    Assignee: North Carolina State University
    Inventors: Behnam Kia, William Ditto, Yaman Dalal, Ravikanth Somsole, Siva Rama Maruthi Ven Donepudi Krishna Sesha Sai, Allen R. Mendes, Akshay Parnami, Robin George
  • Patent number: 11479017
    Abstract: The present invention is directed toward a method of making a composite structure including receiving a substantially planar nonwoven spunbond layer including a plurality of multicomponent fibers, thermally bonding the nonwoven spunbond layer at a first bond temperature, laying down a meltblown layer on top of the thermally bonded nonwoven spunbond layer to form an intermediate structure, and thermally bonding the intermediate structure at a second bond temperature to form a final composite structure. Composite structures including a spunbond layer and a meltblown layer, wherein the composite structure has a tensile strength of at least about 130 N/2.54 cm in both machine and cross directions, a tear strength of at least 3.0 N/2.54 cm, and an LRV of about 2.0 or higher are also provided herein.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: October 25, 2022
    Assignee: North Carolina State University
    Inventors: Benoit Maze, Behnam Pourdeyhimi
  • Patent number: 11472713
    Abstract: Disclosed herein are aluminum oxide aerogels and methods of making and use thereof. The methods of making the aluminum oxide aerogel include contacting a solid comprising aluminum with a Ga-based liquid alloy to dissolve at least a portion of the aluminum from the solid, thereby forming an aluminum-alloy mixture; and contacting the aluminum-alloy mixture with a fluid comprising water, thereby forming the aluminum oxide aerogel. In some examples, the methods can further comprise capturing and converting carbon dioxide to a syngas comprising carbon monoxide and hydrogen.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 18, 2022
    Assignee: North Carolina State University
    Inventors: Paul Maggard, Jerome J. Cuomo, Keith Markham, William Kiether
  • Patent number: 11466054
    Abstract: The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or suppressing the development, maintenance, and proliferation of cancers, including blocking or inhibiting cancer cell metastasis.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 11, 2022
    Assignees: BIOMARCK PHARMACEUTICALS LTD., NORTH CAROLINA STATE UNIVERSITY
    Inventors: Indu Parikh, Kenneth B. Adler
  • Patent number: 11454578
    Abstract: Described herein are passive samplers, making of such samplers, and methods of use. In an example embodiment, a passive sampling membrane comprises, for example, a continuous mesoporous sequestration media having a sequestration phase and a support membrane configured to support the sequestration phase. The sequestration phase may include a hydrophobic region and a hydrophilic region. The continuous mesoporous sequestration media may be configured to simultaneously sequester polar and non-polar organic substances.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 27, 2022
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Damian Shea, Xiang Q. Kong, Xin-Rui Xia
  • Patent number: 11452294
    Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 27, 2022
    Assignees: North Carolina State University, Clemson University Research Foundation
    Inventors: Fred H. Yelverton, Lambert McCarty
  • Patent number: 11452706
    Abstract: The invention relates to a low sugar or sugar free concentrated polyphenolic extract comprising at least about 30% polyphenols (w/w) and a protein-polyphenol aggregate matrix comprising at least about 15% polyphenols (w/w). The invention further relates to methods of producing a low sugar or sugar free concentrated polyphenolic extract comprising (a) extracting a low sugar or sugar free plant tissue with an aqueous solvent to produce an extract having an aqueous portion and a solids portion; (b) filtering the extract to separate the aqueous portion from the solids portion; and (c) reducing the volume of the separated aqueous portion, and methods of producing a protein-polyphenol aggregate matrix comprising about 1% to about 40% polyphenols (w/w) using the low sugar or sugar free concentrated polyphenolic extract of the invention.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 27, 2022
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Mary Ann Lila, Mary H. Grace
  • Patent number: 11439712
    Abstract: The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 13, 2022
    Assignee: North Carolina State University
    Inventors: Chase Beisel, Michelle Luo
  • Patent number: 11439194
    Abstract: Various examples are provided for obtaining body measurements of a user, predicting body measurements of a user, and/or the like. Examples include a coded dimensioning garment having a stretchable fabric that conforms to a wearer's body without substantial compression or distortion of the skin. The garment can include measurement markings of known sizes at one or more known locations on the fabric. Methods are provided for predicting body measurements from a user. Image(s) of a user wearing the garment in a reference pose are captured and can be uploaded to a body measurement application. The real-world dimensions can be converted to pixel dimensions in the same ratio as the real world dimensions and inputted into a prediction model to generate measurements from areas of interest on the user.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 13, 2022
    Assignee: North Carolina State University
    Inventors: Cynthia L. Istook, Andre J. West, Sibei Xia, Jiayin Li, James Beebe Hawes Collier
  • Publication number: 20220273117
    Abstract: A mosquito control net includes an occupant chamber and a trap chamber disposed over the occupant chamber. The trap chamber has one or more openings disposed on an outer surface thereof, through which mosquitos enter the trap chamber, the openings having receptacles attached therein and extending within the trap chamber to inhibit egression of mosquitos from the trap chamber after entry. A method for preventing mosquito bites for a subject can include providing such a mosquito control net and having the subject occupy it. A kit of parts for converting a conventional mosquito control net into a trapping mosquito control net can comprise a funnel-shaped receptacle surrounded by a bag, the bag being substantially impermeable to mosquitos and the receptacle and/or the bag being attachable to a top surface of the conventional mosquito control net to form a trap compartment.
    Type: Application
    Filed: August 6, 2020
    Publication date: September 1, 2022
    Applicant: North Carolina State University
    Inventors: Chouaïbou Seïdou Mouhamadou, Richard Michael Roe, Robert D. Mitchell, III, Charles S. Apperson, Marian Gayle McCord, Andre J. West
  • Publication number: 20220275388
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Application
    Filed: March 1, 2022
    Publication date: September 1, 2022
    Applicants: North Carolina State University, University of Kentucky Research Foundation
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Patent number: 11419892
    Abstract: Disclosed herein are platelet-like particles incorporating antimicrobial metallic nanoparticles. The platelet-like particles include an ultra-low crosslinked polymeric microgel and fibrin targeting moiety. The antimicrobial metallic nanoparticles can be covalently or noncovalently incorporated into the platelet-like particles. The particles are useful to stop bleeding and to promote wound healing while at the same time suppressing bacterial infections that can accompany tissue damage.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: August 23, 2022
    Assignee: North Carolina State University
    Inventors: Ashley Brown, Erin Sproul
  • Patent number: 11419354
    Abstract: The presently disclosed subject matter is directed to a system and method of extracting bioactive agents from biomass using continuous microwave-assisted extraction. The disclosed system includes a plurality of microwave modules that exposes the biomass to continuous microwave energy, and an extraction module to extract bioactive agents from the biomass. In some embodiments, the biomass is exposed to subcritical water treatment in the microwave modules. The disclosed system enables bioactive agent to be extracted effectively, in a relatively short period of time compared to conventional extraction methods and allows for an enhanced extraction yield.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 23, 2022
    Assignees: NORTH CAROLINA STATE UNIVERSITY, SINNOVATEK, INC.
    Inventors: Michael Druga, Amanda Vargochik, Josip Simunovic
  • Patent number: PP34712
    Abstract: ‘NCMS3’ is a new cultivar of Miscanthus sinensis particularly distinguished by its triploid cytotype, low female fertility, and attractive variegated foliage and showy inflorescences. ‘NCMS3’ provides an attractive and highly infertile alternative to diploid cultivars where reseeding and naturalization is a concern.
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: November 1, 2022
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Thomas Ranney, Darren H. Touchell, Andra Windorf Nus, Irene Palmer, Nathan Lynch