Patents Assigned to North Carolina State University
  • Patent number: 10383299
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 20, 2019
    Assignees: North Carolina State University, University of Kentucky Research Foundation
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Patent number: 10368798
    Abstract: Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
    Type: Grant
    Filed: June 29, 2014
    Date of Patent: August 6, 2019
    Assignee: North Carolina State University
    Inventors: Alper Bozkurt, James P. Dieffenderfer
  • Publication number: 20190233905
    Abstract: The instant disclosure provides norovirus-binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Applicant: North Carolina State University
    Inventors: Lee-Ann Jaykus, Blanca Irene Escudero-Abarca, Matthew D. Moore, Helen Rawsthorne
  • Patent number: 10363226
    Abstract: Disclosed herein is a platelet membrane-coated nanovehicle having an inner core comprising a drug delivery matrix, and an outer shell platelet membrane coating the inner core. The inner core can be any drug delivery matrix capable of delivering a therapeutic agent to a cell. The outer shell platelet membrane can be a natural or synthetic membrane comprising platelet proteins capable of interacting with cancer cells. Also disclosed is a method for treating cancer in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein. Also disclosed is a method for treating vascular disease in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 30, 2019
    Assignee: North Carolina State University
    Inventors: Zhen Gu, Quanyin Hu
  • Publication number: 20190222024
    Abstract: A method, a system, and computer readable medium for managing thermostatically controlled loads (TLCs). The method includes acquiring data from a plurality of TCLs including at least thermal parameters associated with each TCL of the plurality of TCLs and a regulation signal data and prioritizing the plurality of TCLs. The prioritization is based on a contribution of each TCL to an overall service. The method further includes generating an optimization curve based on the prioritization, determining an optimization attribute associated with each TCL of the plurality of TCLs, and outputting the optimization attribute associated with each TCL for a regulation period to each TCL. The optimization curve has at least reward criteria as an optimization parameter.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 18, 2019
    Applicants: TOTAL SOLAR INTERNATIONAL, NORTH CAROLINA STATE UNIVERSITY
    Inventors: Maziar VANOUNI, Ning Lu, Wente Zeng
  • Publication number: 20190216143
    Abstract: A protective garment system including a bib configured to fit around at least part of an upper portion of a torso of a wearer. The bib includes an outer material and a particulate-blocking material which is configured to be positioned between the outer material and a wearer when the bib is worn. The bib has a perimeter and is configured to be releasably attached to a pair of trousers about the perimeter.
    Type: Application
    Filed: September 11, 2018
    Publication date: July 18, 2019
    Applicants: Lion Group, Inc., North Carolina State University
    Inventors: Richard H. Harris, Alysha Lynn Gray, Kathryn Ann York, Cassandra H. Kwon, Marc Christopher Mathews, Chandler Ross Maness, Robert Bryan Ormond
  • Publication number: 20190222244
    Abstract: Tunable filters, cancellers, and duplexers based on passive mixers. A tunable delay cell includes passive mixers electrically coupled together for receiving an input signal and outputting a delayed signal, each passive mixer comprising a plurality of mixer switches. The tunable delay includes a control circuit for providing, to each passive mixer, a respective plurality of local oscillator (LO) signals, one to each mixer switch of each passive mixer. The control circuit is configured to vary the LO signals to cause a target frequency band of the input signal to be delayed by a target delay time in propagating through the passive mixers.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 18, 2019
    Applicant: North Carolina State University
    Inventors: Brian Allan Floyd, Charley Theodore Wilson, III, Jeffrey Franklin Bonner-Stewart
  • Patent number: 10355132
    Abstract: An insulated-gate field effect transistor includes a substrate having a drift region and a source region of first conductivity type, and a base region and shielding region of second conductivity type therein. The base region forms a first P-N junction with the source region and the shielding region extends between the drift region and the base region. A transition region of first conductivity type is provided, which is electrically coupled to the drift region. The transition region extends between a first surface of the substrate and the shielding region, and forms a second P-N junction with the base region. An insulated gate electrode is provided on a first surface of the substrate. The insulated gate electrode has an electrically conductive gate therein with a drain-side sidewall extending intermediate the second P-N junction and an end of the shielding region when viewed in transverse cross-section.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: July 16, 2019
    Assignee: North Carolina State University
    Inventor: Bantval Jayant Baliga
  • Patent number: 10352914
    Abstract: An environmental stimulus sensor includes a substrate, a p-type material, and a conductive contact. In some aspects the conductive contact couples an electrode to the p-type material for supplying a current through the p-type material. The p-type material includes a nanotile structure for responding to an environmental stimulus by changing resistance.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: July 16, 2019
    Assignee: North Carolina State University
    Inventors: Bongmook Lee, Veena Misra
  • Patent number: 10335294
    Abstract: An example system for tuning powered prosthesis impedance control parameters can include a powered prosthesis and intelligent tuner operably connected to the powered prosthesis. The powered prosthesis can include a joint, a motor that is mechanically coupled to the joint, a plurality of sensors configured to measure a plurality of gait parameters associated with a subject, and an impedance controller. The motor of the powered prosthesis can be configured to drive the joint, and the impedance controller of the powered prosthesis can be configured to output a control signal for adjusting a torque of the motor, where the torque is adjusted as a function of the measured gait parameters and a plurality of impedance control parameters. The intelligent tuner can be configured to adjust at least one of the impedance control parameters using a rule base.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 2, 2019
    Assignee: North Carolina State University
    Inventors: He Huang, Ming Liu
  • Patent number: 10334874
    Abstract: Methods for producing dissolving grade pulp and microcrystalline cellulose from tobacco are provided. The methods include chemical pulping a tobacco input to form a tobacco pulp. Chemical pulping the tobacco input includes combining the tobacco input with a strong base defining a weight from about 5% to about 50% of the tobacco input, and heating the tobacco input and the strong base with an H-factor from about 500 to about 3,300. Further, the methods include bleaching the tobacco pulp to produce a dissolving grade pulp. Bleaching the tobacco pulp may include chlorination of the tobacco pulp with a chlorine dioxide solution, and caustic extraction of the tobacco pulp with a second strong base. A related tobacco-derived microcrystalline cellulose product is also provided, which can be used as a binder, a filler, and/or a texturizer in a tobacco product, such as a smokeless tobacco product.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 2, 2019
    Assignees: R. J. Reynolds Tobacco Company, North Carolina State University
    Inventors: Medwick Vaughan Byrd, Jr., Paul Stuart Chapman, Samuel Mark Debusk, Grady Lance Dooly, Anthony Richard Gerardi, David Neil McClanahan
  • Patent number: 10333569
    Abstract: Tunable filters, cancellers, and duplexers based on passive mixers. A tunable delay cell includes passive mixers electrically coupled together for receiving an input signal and outputting a delayed signal, each passive mixer comprising a plurality of mixer switches. The tunable delay includes a control circuit for providing, to each passive mixer, a respective plurality of local oscillator (LO) signals, one to each mixer switch of each passive mixer. The control circuit is configured to vary the LO signals to cause a target frequency band of the input signal to be delayed by a target delay time in propagating through the passive mixers.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 25, 2019
    Assignee: North Carolina State University
    Inventors: Brian Allan Floyd, Charley Theodore Wilson, III, Jeffrey Franklin Bonner-Stewart
  • Patent number: 10325875
    Abstract: Disclosed is an integrated circuit packaging system that includes first and second microchips. Each microchip includes a top surface, a surface, one or more quilt package nodules fabricated on said top surface, and one or more bottom surface connectors. The system also includes a substrate to which the first and second microchips are mounted. The first and second microchips are connected via the quilt package nodules.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 18, 2019
    Assignees: North Carolina State University, Indiana Integrated Circuits, LLC
    Inventors: Jason M. Kulick, Douglas Hopkins
  • Patent number: 10324983
    Abstract: Recurrent neural networks (RNNs) can be visualized. For example, a processor can receive vectors indicating values of nodes in a gate of a RNN. The values can result from processing data at the gate during a sequence of time steps. The processor can group the nodes into clusters by applying a clustering method to the values of the nodes. The processor can generate a first graphical element visually indicating how the respective values of the nodes in a cluster changed during the sequence of time steps. The processor can also determine a reference value based on multiple values for multiple nodes in the cluster, and generate a second graphical element visually representing how the respective values of the nodes in the cluster each relate to the reference value. The processor can cause a display to output a graphical user interface having the first graphical element and the second graphical element.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: June 18, 2019
    Assignees: SAS INSTITUTE INC., NORTH CAROLINA STATE UNIVERSITY
    Inventors: Samuel Paul Leeman-Munk, Saratendu Sethi, Christopher Graham Healey, Shaoliang Nie, Kalpesh Padia, Ravinder Devarajan, David James Caira, Jordan Riley Benson, James Allen Cox, Lawrence E. Lewis
  • Patent number: 10308989
    Abstract: The instant disclosure provides norovirus binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: June 4, 2019
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Lee-Ann Jaykus, Blanca Irene Escudero-Abarca, Matthew D. Moore, Helen Rawsthorne
  • Patent number: 10311356
    Abstract: An unsupervised behavior learning system and method for predicting anomalies in a distributed computing infrastructure. The distributed computing infrastructure includes a plurality of computer machines. The system includes a first computer machine and a second computer machine. The second computer machine is configured to generate a model of normal and anomalous behavior of the first computer machine, where the model is based on unlabeled training data. The second computer machine is also configured to acquire real-time data of system level metrics of the first machine; determine whether the real-time data is normal or anomalous based on a comparison of the real-time data to the model; and predict a future failure of the first computer machine based on multiple consecutive comparisons of the real-time data to the model.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 4, 2019
    Assignee: North Carolina State University
    Inventors: Xiaohui Gu, Daniel Dean
  • Patent number: 10292353
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: May 21, 2019
    Assignees: NORTH CAROLINA STATE UNIVERSITY, UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Patent number: 10278395
    Abstract: This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 7, 2019
    Assignee: North Carolina State University
    Inventors: Orlin D. Velev, Alexander P. Richter
  • Patent number: PP30431
    Abstract: A new and distinct Hydrangea cultivar named ‘NCHA8’ is disclosed, characterized by large, mop-head inflorescences with florets that open green and progress to white. Plants have a compact, rounded and upright habit with strong stems. Plants are triploid. The new variety is a Hydrangea normally produced as an outdoor garden or container plant.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: April 23, 2019
    Assignee: North Carolina State University
    Inventor: Thomas Green Ranney
  • Patent number: PP30788
    Abstract: ‘NCPX2’ is a new triploid, interspecific hybrid flowering pear with a broadly pyramidal habit, white flowers, multi-coloured fall foliage, resistance to fire blight, and significantly reduced fertility.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: August 13, 2019
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventor: Thomas G. Ranney