Abstract: Compositions that include a polymer and an aldaric acid, such as glucaric acid, are disclosed. The compositions may include polyvinyl alcohol and glucaric acid. The compositions may also include polyacrylonitrile and glucaric acid. In addition, the compositions may further include lignin. Also disclosed are fibers including the compositions, methods of making the fibers, and uses of the fibers.

Abstract: One-step methods for forming phosphate-based enzyme inhibitors are disclosed. Methods include reacting o-phosphorylethanolamine with an acyl chloride at acidic conditions. Acyl chlorides can be derivatized. The phosphate-based enzyme inhibitors can inhibit enzymes of the pentose phosphate pathway including D-ribose-5-phosphate aldose-ketose isomerase enzymes such as T. cruzi ribose 5-phosphate isomerase type B and D-ribulose-5-phosphate 3-epimerase enzymes. Methods can be used in forming pharmaceutical compositions for use in treatment of disease caused by kinetoplastid parasites including T. cruzi, T. brucei, and Leishmania spp.

Abstract: The invention is directed to antibacterial compositions comprising bacteria modified to comprise phasmids engineered to deliver of CRISPR RNAs and methods for their use.

Abstract: Compositions and methods for treating diseases and conditions mediated by the high affinity IgE receptor (Fc?RI) are provided. Also provided are antisense oligomers for modulating splicing of mRNA encoding a MS4A6A protein, optionally in addition to antisense oligomers for modulating splicing of mRNA encoding the Fc?RI? protein, thereby down-regulating cell-surface expression of Fc?RI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation; for inhibiting anaphylaxis reactions in individuals, for treating allergic conditions in individuals, for reducing the incidence of allergic reactions in individuals, for treating individuals at risk of developing anaphylactic reactions, and for treating mast cell-related diseases in individuals.

Abstract: A decoupled ETP model processor is configured to store power consumption data retrieved from power systems; convert the power consumption data into power activated time cycles and power non-activated time cycles; derive a thermal resistance (R) parameter and a capacitance (C) parameter for a predetermined heat flow (Q) parameter at each of the outdoor temperatures; compare the converted power activated time cycles to the actual power activated time cycles; compare the converted power non-activated time cycles to the actual power non-activated time cycles; calculate a first improved resistance-capacitance-heat flow (RCQ) parameter set and a respective first outdoor temperature for the compared and converted power activated time cycles to the actual power activated time cycles; calculate the Q parameter at each outdoor temperature during the power activated time cycles; and calculate the R parameter and the C parameter at each outdoor temperature during the power non-activated time cycles.

Abstract: Methods for treating diseases and conditions mediated by the high affinity IgE receptor (Fc?RI). Antisense oligomers for modulating splicing of mRNA encoding the Fc?RI? protein, thereby down-regulating cell-surface expression of Fc?RI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.

Abstract: Described herein are devices and methods of use thereof, the devices comprising: a sample conduit providing a path for fluid flow extending from a sample inlet to a sample outlet; a thermal housing enclosing the sample conduit, the thermal housing comprising a plurality of measurement regions; and a motorized stage translatable along the thermal housing so as to align a detector with one or more of the plurality of measurement regions. The devices can continuously flow a fluid precursor sample from the sample inlet to the sample outlet, the fluid precursor sample comprising a first precursor and a second precursor, such that the first precursor reacts with the second precursor as the fluid precursor sample continuously flows from the sample inlet to the sample outlet to form the sample before reaching the sample outlet, wherein the sample comprises a plurality of particles or an organic molecule.

Abstract: The present invention is directed to methods and compositions for typing of Lactobacillus buchneri bacterial strains, detecting the presence of a L. buchneri in a sample, identifying a strain of L. buchneri having resistance to an invasive foreign genetic element, modifying the resistance of bacteria and archeae to an invasive foreign genetic element, and introducing nicks into or cleaving double stranded DNA for genome editing.

Abstract: Hybrid tomato varieties designated ‘VT19077208’ and ‘VT19108230’ are disclosed. ‘VT19077208’ and ‘VT19108230’ are hybrid tomato varieties exhibiting stability and uniformity.

Abstract: A system can include a nonlinear circuit and a voltage decoder. The nonlinear circuit can perform an operation on an input voltage. The operation can be changed. A voltage decoder can be communicatively coupled to the nonlinear circuit for receiving an output voltage from the nonlinear circuit that results from the operation performed on the input voltage. The voltage decoder can compare the output voltage to a threshold voltage and determine a result of the operation.

Abstract: The present disclosure relates to high-throughput detection of polyketides using genetically encoded biosensors.

Abstract: Various implementations include a self-cleaning screen device including a screen and auger. The screen is a hollow cylinder and has a screen central axis, a screen inner surface, a screen outer surface opposite and radially spaced apart from the screen inner surface, a screen first end, and a screen second end opposite and axially spaced apart from the screen first end. The screen outer surface defines a plurality of openings extending radially to the screen inner surface. The auger is helically shaped and has an auger central axis, an auger first end, and an auger second end opposite and axially spaced apart from the auger first end. The auger is disposed around at least a portion of the screen outer surface such that the auger central axis and the screen central axis are coincident with each other. The auger is rotatable about the auger central axis relative to the screen.

Abstract: The present invention is directed toward a method of making a composite structure including receiving a substantially planar nonwoven spunbond layer including a plurality of multicomponent fibers, thermally bonding the nonwoven spunbond layer at a first bond temperature, laying down a meltblown layer on top of the thermally bonded nonwoven spunbond layer to form an intermediate structure, and thermally bonding the intermediate structure at a second bond temperature to form a final composite structure. Composite structures including a spunbond layer and a meltblown layer, wherein the composite structure has a tensile strength of at least about 130 N/2.54 cm in both machine and cross directions, a tear strength of at least 3.0 N/2.54 cm, and an LRV of about 2.0 or higher are also provided herein.

Abstract: Disclosed herein are aluminum oxide aerogels and methods of making and use thereof. The methods of making the aluminum oxide aerogel include contacting a solid comprising aluminum with a Ga-based liquid alloy to dissolve at least a portion of the aluminum from the solid, thereby forming an aluminum-alloy mixture; and contacting the aluminum-alloy mixture with a fluid comprising water, thereby forming the aluminum oxide aerogel. In some examples, the methods can further comprise capturing and converting carbon dioxide to a syngas comprising carbon monoxide and hydrogen.

Abstract: The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or suppressing the development, maintenance, and proliferation of cancers, including blocking or inhibiting cancer cell metastasis.

Abstract: Described herein are passive samplers, making of such samplers, and methods of use. In an example embodiment, a passive sampling membrane comprises, for example, a continuous mesoporous sequestration media having a sequestration phase and a support membrane configured to support the sequestration phase. The sequestration phase may include a hydrophobic region and a hydrophilic region. The continuous mesoporous sequestration media may be configured to simultaneously sequester polar and non-polar organic substances.

Abstract: The invention relates to a low sugar or sugar free concentrated polyphenolic extract comprising at least about 30% polyphenols (w/w) and a protein-polyphenol aggregate matrix comprising at least about 15% polyphenols (w/w). The invention further relates to methods of producing a low sugar or sugar free concentrated polyphenolic extract comprising (a) extracting a low sugar or sugar free plant tissue with an aqueous solvent to produce an extract having an aqueous portion and a solids portion; (b) filtering the extract to separate the aqueous portion from the solids portion; and (c) reducing the volume of the separated aqueous portion, and methods of producing a protein-polyphenol aggregate matrix comprising about 1% to about 40% polyphenols (w/w) using the low sugar or sugar free concentrated polyphenolic extract of the invention.

Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.

Abstract: The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.

Abstract: ‘NCMS3’ is a new cultivar of Miscanthus sinensis particularly distinguished by its triploid cytotype, low female fertility, and attractive variegated foliage and showy inflorescences. ‘NCMS3’ provides an attractive and highly infertile alternative to diploid cultivars where reseeding and naturalization is a concern.