Patents Assigned to North Shore-Long Island Jewish Health System
  • Small-molecule modulators of hepatocyte growth factor / scatter factor activities
    Patent number: 6855728
    Abstract: The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: February 15, 2005
    Assignee: North Shore-Long Island Jewish Health System
    Inventors: Sivaram Pillarisetti, Itzhak D. Goldberg
  • Small-molecule modulators of hepatocyte growth factor/scatter factor activities
    Patent number: 6589997
    Abstract: The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: July 8, 2003
    Assignee: North Shore-Long Island Jewish Health System
    Inventors: Sivaram Pillarisetti, Itzhak D. Goldberg