Abstract: A ?-glycosidase SS-BGL mutant for modifying ginsenoside and application thereof are provided, which relate to the field of genetic engineering technologies. The ?-glycosidase SS-BGL mutant is ?-glycosidase SS-BGL with the amino acid sequence as shown in SEQ ID NO: 1 having mutation at one or more sites. A single-site mutation includes: A1, making glutamine at 96th position of SEQ ID NO: 1 to be mutated to glutamic acid; A2, making asparagine at 97th position of SEQ ID NO: 1 to be mutated to aspartate; A3, making asparagine at 128th position of SEQ ID NO: 1 to be mutated to aspartate; A4, making asparagine at 302th position of SEQ ID NO: 1 to be mutated to aspartate. A double-site mutation is a combination of A3 and A4, a three-site mutation is a combination of A1, A2 and A4, and a four-site mutation is a combination of A1, A2, A3 and A4.

Abstract: The present disclosure belongs to the technical field of monitoring landslide mass geological disasters, and discloses a multi-state triggered system and method for remote automatic monitoring and early warning of a landslide mass. The multi-state triggered system for remote automatic monitoring and early warning of a landslide mass includes: a landslide mass monitoring module, a data preprocessing module, a communication module, a central control module, a displacement monitoring module, a stability evaluation module, an abnormality early warning module, a power supply module, a data storage module and a display update module. In the present disclosure, through the displacement monitoring module and the stability evaluation module, long-term automatic monitoring of the landslide mass can be realized, and the displacement change of the landslide mass can be grasped so as to evaluate the stability of the landslide mass.

Abstract: A glycosyltransferase BS-YjiC mutant, a construction method and an application thereof provided, relating to the field of genetic engineering technologies. The glycosyltransferase BS-YjiC mutant is obtained by performing site-directed mutation on amino acids at the 125th, 178th, 313th, 125th and 178th, or 125th and 313th positions of a wild-type glycosyltransferase BS-YjiC with the amino acid sequence as shown in SEQ ID NO: 1. Compared with the wild-type glycosyltransferase BS-YjiC, the glycosyltransferase BS-YjiC mutant is more suitable for catalyzing protopanaxadiol (PPD) to generate rare ginsenosides F12 and Rh2, which is more conducive to the flexibility of the production process.

Abstract: Disclosed is a method for fermenting Gynostemma pentaphyllum with antihypertensive effect, the method comprising the following steps: 1) pretreatment of Gynostemma pentaphyllum: crushing Gynostemma pentaphyllum raw tea to prepare a homogenate; 2) activation of Tibetan Kefir: activating Tibetan Kefir in sterile milk; and 3) fermentation of Gynostemma pentaphyllum: taking the homogenate of Gynostemma pentaphyllum, the sterile milk and the activated Tibetan Kefir for fermentation.

Abstract: Disclosed is a data analysis-based intelligent deformation monitoring system for mountain landslides, which solves the technical problem in the prior art that when a landslide occurs in a landslide area, it is not possible to implement region-specific monitoring for landslide soil, thus failing to minimize the real-time impact of the landslide area. The present disclosure involves marking a sub-area where a landslide occurs as a landslide area, marking a real-time sliding direction within the landslide area as a landslide flow direction, setting areas at both sides of the landslide flow direction as landslide slopes, generating a control adjustment signal or a risk monitoring signal through landslide slope analysis, and sending the signal to a server.

Abstract: Disclosed is a method for fermenting Gynostemma pentaphyllum with antihypertensive effect, the method comprising the following steps: 1) pretreatment of Gynostemma pentaphyllum: crushing Gynostemma pentaphyllum raw tea to prepare a homogenate; 2) activation of Tibetan Kefir: activating Tibetan Kefir in sterile milk; and 3) fermentation of Gynostemma pentaphyllum: taking the homogenate of Gynostemma pentaphyllum, the sterile milk and the activated Tibetan Kefir for fermentation.

Abstract: Disclosed is a Beidou communication-based integrated monitoring system for a slope surface crack, which in particular relates to the field of geological disaster monitoring. Due to a certain trend of landslide damage degrees, and consequent offsets of a slope area over time, monitoring points pre-arranged possibly become non-optimal monitoring points with undesired monitoring effects. In view of this, the present disclosure includes an arrangement module, a monitoring module, an early warning module and a supervision module; and a slope offset threshold is set according to information of a slope, and configured to determine whether positions of the monitoring points are located in a normal area, and under the condition that a slope offset exceeds the threshold, it is indicated that the monitoring points cannot properly monitor the slope area, and need to be rearranged according to an offset direction.

Abstract: Disclosed is an air-ground integrated landslide monitoring method and device. The monitoring method comprises the following steps: step one, performing high-precision (centimeter-level) vertical aerial photogrammetry and oblique photogrammetry on a monitored area by using an unmanned aerial vehicle, and quickly generating a digital topographic map, a digital orthographic map and a digital surface model; step two, performing accurate and intensive monitoring on the monitored area through a monitoring device; and step three, finally sending obtained data to a processor, and after the monitoring data are processed by the processor, sending the data to a remote-control center, so that real-time transformation and spatialization of dynamic landslide monitoring information are achieved. The present disclosure also provides a landslide monitoring device. The landslide monitoring device comprises a control box, a bottom plate and an unmanned aerial vehicle.

Abstract: The present invention discloses a sample loading apparatus for laser ablation, including a target seat, a base, an air channel, an aerosol channel and a sample chamber, wherein a shrinking mouth is formed in the top of the sample chamber and positioned on a lower surface of the aerosol channel; a spring is arranged in the sample chamber; an opening is formed in a lower surface of the sample chamber and communicated with an air outlet; a stop valve is arranged at the air outlet; one end of the aerosol channel is communicated with a carrier gas inlet, and the other end is communicated with an aerosol outlet; and a top of the aerosol channel includes a first transparent material. The present invention increases stable reliability in a continuous use process, and improves consistency of aerosol transmission efficiency, so that different samples are analyzed.

Abstract: Disclosed herein is a method of optical modulation, the method comprising irradiating an optical switch with a control beam at a first control time and irradiating the optical switch with a signal beam at a signal time. The transmitted intensity of the signal beam in a direction depends on the delay time between the first control time and the signal time and the transmitted intensity of the signal beam in the direction is detectably different than a static signal. The optical switch comprises a nanorod array, the nanorod array comprising a plurality of nanorods extending outwardly from a substrate.

Abstract: Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties.

Abstract: The present invention relates to a compound of the formula (I), wherein R1, R2 and R3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R1 and R2 together form —OCH2O—, R3 is selected from H, OH, methoxy, ethoxy and halogens; R4 is OH or acyloxy; R5 is cycloalkoxyl, amino and substituted amino, and when R5 is selected from amino, at least one of R1, R2 and R3 is not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases.

Abstract: The present invention discloses a new and improved kind of chromatographic cake and its manufacturing methods and applications. The objective of this invention is to provide an improved chromatographic apparatus and methods for manufacturing such an apparatus, whereby the separation and simultaneous renaturation and purification of biopolymers can be efficiently performed with excellent results. The chromatographic cakes of this invention generally comprise a chromatographic packing cake with a mobile phase inlet and a mobile phase outlet, together with a chromatographic packing packed into an inner cavity region of the chromatographic packing cake. The ratio of the thickness to the diameter of the inner cavity region of the chromatographic packing cake is less than or equal to 1.

Abstract: The present invention provides a class of semi-interpenetrating polymeric networks that include a linear polymer molecule functionalized with a bioactive moiety. The linear polymer is physically entangled within a matrix based upon a thermo-responsive polymer. The bioactive moiety is, e.g., a therapeutic moiety or a moiety that enhances the interaction of a cell with the polymer network. The polymer networks of the invention are flowable at room temperature, becoming solid or semi-solid at elevated temperatures (e.g., body temperature). The polymer networks are of use as drug delivery vehicles and as matrices for tissue engineering.