Abstract: The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
October 12, 2006
Date of Patent:
February 2, 2010
Assignees:
Children's Medical Center Corp., The General Hospital Corp., Northeastern Ohio Universities COM
Inventors:
Evan Y. Snyder, Xandra O. Breakefield, Karen S. Aboody, Ulrich Herrlinger, William P. Lynch