Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.

Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.

Abstract: Methods and compositions disclosed herein relate to detecting, analyzing, isolating and inhibiting methyltransferases, methyltransferase substrates, S-adenosyl-methionine-binding proteins and RNA, including for the treatment of disease.

Abstract: The increase in antibacterial resistance has created the demand for new antibiotics. The present invention relates to a more potent antibiotic that targets the enzyme glutamate racemase from known glutamate racemase inhibitors. Glutamate racemase catalyses the interconversion of L-glutamate to D-glutamate, making D-glutamate available, which is required for bacterial peptidoglycan biosynthesis. Knockout mutations have shown glutamate racemase to be necessary for bacterial cell survival and, before the present invention, no antibiotic on the market targeted this enzyme. The present invention relates to new, ligand based glutamate racemase inhibitors, developed using software to extract a pharmacophore model from a group of known glutamate racemase inhibitors. Forty-seven (47) known inhibitors were collected from the literature and several pharmacophore models were extracted therefrom.

Abstract: Method and apparatus for TWB forming with adaptive control of movable punch and/or die segments in a manner to maintain a holding force at the weld line by the punch and die segments during at least initial forming of the blank in a manner to control and limit movement of the weld line. A tailor welded metal blank having a weld line is positioned between a punch and a die with the weld line spanning a cavity defined between the punch and the die. One or more individual segments of the punch and of the die are moved in a manner to engage opposite side regions of the weld line to apply a holding force to the weld line. Relative movement of the punch and/or die segments is adaptively controlled during at least initial deformation of the blank by the punch in a manner to maintain the holding force applied to weld line at a selected holding force value to retain the weld line in a plane defined by the punch and die segments, thereby reducing weld line movement.

Abstract: An automatic alignment vise capable of automatically precisely positioning a workpiece to be machined. The vise can provide precise three dimensional positioning in response to data signals provided by a robotic device, a vertical milling machine or other machining device. The vise allows precise machining of all faces of the workpiece.