Abstract: A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.
Type:
Grant
Filed:
April 9, 2018
Date of Patent:
July 21, 2020
Assignees:
SOUTHWEST RESEARCH INSTITUTE, NORTHWESTER UNIVERSITY
Inventors:
XingGou Cheng, Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong, Ping Xie, Shengxian Jia
Abstract: Disclosed herein is a method of optical modulation, the method comprising irradiating an optical switch with a control beam at a first control time and irradiating the optical switch with a signal beam at a signal time. The transmitted intensity of the signal beam in a direction depends on the delay time between the first control time and the signal time and the transmitted intensity of the signal beam in the direction is detectably different than a static signal. The optical switch comprises a nanorod array, the nanorod array comprising a plurality of nanorods extending outwardly from a substrate.
Abstract: Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties.
Type:
Grant
Filed:
October 14, 2013
Date of Patent:
January 23, 2018
Assignee:
Northwester University
Inventors:
John M. Torkelson, Cynthia Pierre, Amanda Flores Walker, Philip J. Brunner
Abstract: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.
Type:
Application
Filed:
March 15, 2012
Publication date:
August 16, 2012
Applicant:
NORTHWESTER UNIVERSITY
Inventors:
DAVID M. KELSO, Kunal Sur, Zaheer Parpia