Abstract: A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.
Type:
Grant
Filed:
April 9, 2018
Date of Patent:
July 21, 2020
Assignees:
SOUTHWEST RESEARCH INSTITUTE, NORTHWESTER UNIVERSITY
Inventors:
XingGou Cheng, Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong, Ping Xie, Shengxian Jia
Abstract: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.
Type:
Application
Filed:
March 15, 2012
Publication date:
August 16, 2012
Applicant:
NORTHWESTER UNIVERSITY
Inventors:
DAVID M. KELSO, Kunal Sur, Zaheer Parpia