Patents Assigned to NORTHWESTERN UNIVERITY
  • Nanoconjugates able to cross the blood-brain barrier
    Patent number: 10398784
    Abstract: Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (BBB) and is thus effective in the treatment of central nervous system (CNS) disorders. Further, despite the tremendously high cellular uptake of nanoconjugates, they exhibit no toxicity in the cell types tested thus far. This property is critical for therapeutic agent delivery applications for reducing off-target effects.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 3, 2019
    Assignee: NORTHWESTERN UNIVERITY
    Inventors: Chad A. Mirkin, Caroline H. Ko, David A. Giljohann, Janina Luciano, Samuel A. Jensen, Alexander Stegh