Patents Assigned to Nortic Holdings Inc.
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Publication number: 20200397773Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Applicant: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru
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Publication number: 20200397769Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: ApplicationFiled: September 8, 2020Publication date: December 24, 2020Applicant: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Patent number: 10799486Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: GrantFiled: July 26, 2018Date of Patent: October 13, 2020Assignee: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Patent number: 10765671Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: GrantFiled: July 26, 2018Date of Patent: September 8, 2020Assignee: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru
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Publication number: 20200197338Abstract: A nasal spray formulation and a method of using a locally acting sodium channel blocker to treat pain is disclosed, wherein the nasal spray formulation comprises from about 5% to about 30% w/v of a locally active sodium channel blocker, from about 0.25% to about 5% w/v of a buffering agent, and from about 5 to about 99% w/v of a pharmaceutically acceptable carrier for nasal administration. The nasal spray formulation is preferably contained in a mechanical multi-dose pump which sprays a unit dose of the nasal spray formulation with a wide plume and small droplet size, such that the unit dose is administered by actuating the mechanical multi-dose spray pump device and spraying a volume of the nasal spray formulation into each nostril of a human subject. Preferably, the nasal spray formulation does not include a preservative.Type: ApplicationFiled: December 4, 2019Publication date: June 25, 2020Applicant: Nortic Holdings Inc.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Publication number: 20200163947Abstract: A method of treating a human patient suffering from subarachnoid hemorrhage (SAH), intra-cerebral hemorrhage, and traumatic brain injuries (TBI), and the like, comprising administering a nimodipine formulation suitable for parenteral injection, e.g., either via the subcutaneous or intramuscular route, is disclosed.Type: ApplicationFiled: October 31, 2019Publication date: May 28, 2020Applicant: Nortic Holdings Inc.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Publication number: 20190255033Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution substantially free of organic solvent, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: ApplicationFiled: February 21, 2019Publication date: August 22, 2019Applicant: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Publication number: 20180325886Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: ApplicationFiled: July 26, 2018Publication date: November 15, 2018Applicant: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru
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Publication number: 20180325882Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: ApplicationFiled: July 26, 2018Publication date: November 15, 2018Applicant: NORTIC HOLDINGS INC.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Patent number: 10092553Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: GrantFiled: June 30, 2017Date of Patent: October 9, 2018Assignee: Nortic Holdings Inc.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru, Kamalkishore Pati
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Patent number: 10092557Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.Type: GrantFiled: April 12, 2017Date of Patent: October 9, 2018Assignee: Nortic Holdings Inc.Inventors: S. George Kottayil, Amresh Kumar, Prasanna Sunthankar, Vimal Kavuru