Patents Assigned to Norval B. Galloway
  • Oligonucleotides complementary to mycobacterial nucleic acids
    Patent number: 5521300
    Abstract: Disclosed are nucleic acid oligonucleotides which are substantially complementary to nucleic acids from Mycobacteria, and subgeneric classes thereof. More specifically, the oligonucleotides are complementary to ribosomal RNA (rRNA) and the DNA encoding rRNA (rDNA). Uses for such oligonucleotides include detection of Mycobacteria by hybridization and amplification of Mycobacterial nucleic acid by polymerase chain reaction.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: May 28, 1996
    Assignee: Norval B. Galloway
    Inventors: Jyotsna S. Shah, Ray M. Nietupski, Jing Liu
  • Methods and compositions for reducing false positive signals in an RNA amplification system
    Patent number: 5464744
    Abstract: Disclosed herein is a composition comprising ribonuclease treated RNA or DNA dependent RNA polymerase, and the use of same in amplification methods. The treatment of the RNA or DNA dependent RNA polymerase with ribonuclease reduces or eliminates false positives which result from the presence of an endogenous or contaminating replicatable template species in the Q.beta. replicase enzyme preparation.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: November 7, 1995
    Assignee: Norval B. Galloway
    Inventors: Michael P. Farrell, Juili L. Lin-Goerke