Abstract: The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cyclopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.

Abstract: The invention involves a method for treating or preventing a malignant hyperthermic reaction in a human or lower animal by administering a safe and effective amount of azumolene.

Abstract: The invention involves a method for achieving systemic administration of azumolene by delivering the drug to the intestines without exposing the drug in the stomach, and pharmaceutical compositions for achieving such administration of azumolene.

Abstract: The present invention involves compounds of the class of acylphosphorotriamides and methods for altering the blood plasma lipid content of mammals which comprises systemically administering to mammals an effective but nontoxic amount of a composition comprising such compounds.

Abstract: The invention involves a sustained release pharmaceutical capsule for oral administration comprising, in a capsule shell, a particulate mixture comprising an active drug ingredient which is a weak acid, neutral, or a weak base, polyvinylpyrrolidone, and carboxyvinylpolymer.

Abstract: The invention involves a combination sustained release/rapid release pharmaceutical capsule for oral administration of nitrofurantoin comprising, in a capsule shell, a first layer of a first particulate mixture comprising nitrofurantoin, polyvinylpyrrolidone and carboxyvinylpolymer; and a second layer of a second particulate mixture comprising macrocrystalline nitrofurantoin.

Abstract: The present invention involves compounds of the class of imidazo[4,5-f]quinolines and methods for enhancing the immune response system of mammals which comprises systemically administering to mammals having a depressed immune function an effective but nontoxic amount of a composition comprising such a compound.

Abstract: A furazolidone dosage unit form comprises the drug furazolidone, a sustained release matrix, and an enteric coating.

Abstract: The present invention involves compounds of the class of acylphosphorotriamides and methods for altering the blood plasma lipid content of mammals which comprises systemically administering to mammals an effective but nontoxic amount of a composition comprising such compounds.

Abstract: An elongated rod-shaped medical device has a weighted portion of greater density than adjacent portions thereof for providing useful weight in light medical devices. The weighted portion has a plurality of interfitting metallic weights with facing, engaging sliding surfaces to provide for high specific gravity and high bulk density in a yieldable small diameter device.

Abstract: Certain 5-phenyl-2-furoic acid hydrazides of the formula: ##STR1## wherein X represents 4-chloro, 4-fluoro, 3-trifluoromethyl or hydrogen, R.sub.1 represents hydrogen or methyl, R.sub.2 represents acetyl, isopropyl or methyl, and R.sub.1 and R.sub.2 taken together represent isopropylidene or 4-pyridinylmethylene are useful as anti-inflammatory agents.

Abstract: The invention involves compositions useful for treating certain malignant tumors with the compound ethyl 4-hydroxy-2-[(5-morpholinomethyl-2-oxo)-3-oxazolidinyliminomethyl]furo[2,3 -b]pyridine-5-carboxylate (Compound I) or its pharmaceutically acceptable salts or hydrates.

Abstract: New thiocyanatoquinoxaline compounds useful as immunomodulating agents which have the general formula: ##STR1## wherein R is hydrogen, methyl or 5-thiocyanato-2-furanyl; R.sub.1 is hydrogen, methyl or 2-furanyl; or R and R.sub.1 taken together completes a cyclohexyl ring.

Abstract: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof wherein the metal moiety is selected from the group consisting of silver, zinc, cerium and cobalt are useful in the treatment of burns. These compounds may be applied to the affected surface of a burn victim either directly or as part of a composition together with a physiologically acceptable carrier, such as a water-dispersible, hydrophilic carrier.

Abstract: A series of 1-[acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids and salts thereof are useful as Angiotensin I converting enzyme inhibitors.

Abstract: Compounds of the formula: ##STR1## wherein R is H or ##STR2## and n is 0 or 1 are useful as angiotensin I converting enzyme inhibitors.

Abstract: N-(4-phenylcyclohexyl)glycines of the formula: ##STR1## and salts thereof wherein R is H or lower alkyl and R.sub.1 is hydrogen or benzoyl are useful as angiotensin I converting enzyme inhibitors.

Abstract: 2-[2-(5-Phenylfurfurylamino)ethyl]pyridines are useful as antihypertensive agents.

Abstract: 5-(p-Chlorophenyl)-2-furaldehyde oxime is useful in treating systemic mycotic infections.

Abstract: 5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate is useful as an antidepressant agent.