Abstract: The invention relates to a diagnostic device 10 for collecting and analysing a biological sample comprising, an energy source providing means for perforating, ablating and/or altering the stratum corneum of an area of skin from which the biological sample is to be collected; a housing 21 for receiving at least one test strip 22, the test strip being adapted to collect biological sample from the perforated, ablated and/or altered area of skin; and analysing means for conducting diagnostic analysis of the collected sample. The invention also relates to a cartridge 20 containing a plurality of test strips 22 for collecting a biological sample, each test strip comprising an absorbent portion 35 for absorbing the biological sample at an area of skin which has had applied thereto an energy source to perforate, ablate or alter the stratum corneum of the skin, wherein said test strips are adapted to facilitate transmission of the energy source to the skin.