Patents Assigned to Notol, Inc.
  • Method and formulation of stimulating nitric oxide synthesis
    Patent number: 5767160
    Abstract: A therapeutic in vitro or in vivo mixture comprising L-arginine and an agonist of nitric oxide synthase, namely nitroglycerin is disclosed for the treatment of diseases related to vasoconstriction, wherein the vasoconstriction is relieved by stimulating the constitutive form of nitric oxide synthase (cNOS) to produce native nitric oxide (NO). The native NO having superior beneficial effect when compared to exogenous NO produced by a L-arginine independent pathway in terms of the ability to reduce clinical endpoints and mortality.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: June 16, 1998
    Assignee: Notol, Inc.
    Inventor: W. H. Kaesemeyer