Abstract: Methods for processing and or removing organic residuals and or impurities from a solgel-derived bioactive glass-ceramic and compositions comprising solgel-derived bioactive glass-ceramics processed using these methods, are described.
Type:
Grant
Filed:
April 4, 2017
Date of Patent:
May 12, 2020
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Chloƫ Goldbach, Gregory J. Pomrink, Roy Layne Howell, Meryem Demir
Abstract: A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 15-45% CaO, 30-70% SiO2, 0-25% Na2O, 0-17% P2O5, 0-10% MgO and 0-5% CaF2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.
Type:
Grant
Filed:
June 5, 2017
Date of Patent:
January 7, 2020
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Qiang Jie, Jiang Chang, Weiming J. Gu, Jipin Zhong, Gregory J. Pomrink
Abstract: A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
Type:
Grant
Filed:
November 15, 2016
Date of Patent:
December 4, 2018
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Gregory J. Pomrink, Jipin Zhong, Zehra Tosun, Roy Layne Howell, Cecilia Cao
Abstract: A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 15-45% CaO, 30-70% SiO2, 0-25% Na2O, 0-17% P2O5, 0-10% MgO and 0-5% CaF2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.
Type:
Application
Filed:
June 5, 2017
Publication date:
December 14, 2017
Applicant:
NOVABONE PRODUCTS, LLC
Inventors:
Qiang Jie, Jiang Chang, Weiming J. Gu, Jipin Zhong, Gregory J. Pomrink
Abstract: A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 24-45% CaO, 34-50% SiO2, 0-25% Na2O, 5-17% P2O5, 0-5% MgO and 0-1% CaF2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.
Abstract: A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCI, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
Type:
Application
Filed:
November 15, 2016
Publication date:
March 2, 2017
Applicant:
NovaBone Products, LLC
Inventors:
Gregory J. Pomrink, Jipin Zhong, Zehra Tosun, Roy Layne Howell, Cecilia Cao
Abstract: Compositions including bioactive glass ceramic material surface-coated with a metallic material and methods of making and using the metallic material-coated compositions.
Type:
Application
Filed:
August 30, 2016
Publication date:
March 2, 2017
Applicant:
NovaBone Products, LLC
Inventors:
Gregory J. Pomrink, Zehra Tosun, R. Layne Howell
Abstract: A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof which include introducing Na2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
Type:
Grant
Filed:
March 11, 2014
Date of Patent:
November 22, 2016
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Gregory J. Pomrink, Jipin Zhong, Zehra Tosun, Roy Layne Howell, Cecilia Cao
Abstract: A settable osteostimulative bone graft putty composition having a bioactive glass particulate component composed of a long-term and a short-term component; the long-term component having particle sizes greater than 90 micrometers and the short-term component having particle sizes less than 90 micrometers; the long-term component comprising about 60% to 90% of the bioactive glass osteostimulative particulate component dry weight and the short-term component comprising about 40% to 10%; a binder component having a calcium sulfate component and a calcium silicate component; the calcium sulfate component comprising about 35% to 50% of the binder component dry weight and the calcium silicate component comprising about 65% to 50%; the bioactive glass osteostimulative particulate component being about 20% to 60% of the total putty dry weight composition and the binder being about 80% to 40%; the bioactive glass particulate component and the binder component mixable in water to form the putty.
Abstract: A composition including calcium salt and silica, wherein the silica is in the form of a silicate that is adsorbed onto the surface of the calcium salt, wherein the silica is not incorporated into the structure of the calcium salt, and wherein the composition is bioactive.
Abstract: Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for regenerating bone comprising collagen and bioactive glass are provided.
Type:
Grant
Filed:
December 16, 2014
Date of Patent:
December 1, 2015
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Dennis McBride, Joshua P. Clark, Richard Davis, Gregory J. Pomrink, Zehra Tosun, David C. Greenspan
Abstract: This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.
Abstract: Compositions including crosslinked collagen and bioactive glass having an average pore size of at least 100 microns and methods of preparation thereof.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
September 29, 2015
Assignee:
NOVABONE PRODUCTS, LLC
Inventors:
Gregory J. Pomrink, Cecilia A. Cao, Joshua Clark, Zehra Tosun, David C. Greenspan, Srinivas Katta
Abstract: Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for regenerating bone comprising collagen and bioactive glass are provided.
Type:
Application
Filed:
December 16, 2014
Publication date:
April 16, 2015
Applicant:
NOVABONE PRODUCTS, LLC
Inventors:
Dennis McBride, Joshua P. Clark, Richard Davis, Gregory J. Pomrink, Zehra Tosun
Abstract: The invention relates to the use of a bioactive glass material. For example, an autograft chip is wrapped in bioactive glass material for the treatment of bone injuries and bone defects in the body. The material can be in one or more of several forms, such as fibers, a fiber mesh, a sheet, or another shape. The material can be applied to hard tissues, such as bone.
Abstract: This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.
Abstract: One or more particles of bioactive glass coated with a glycosaminoglycan, wherein the glycosaminoglycan is bound to the bioactive glass and methods of treatment using such particles.
Abstract: A composition including calcium salt and silica, wherein the silica is in the form of a silicate that is adsorbed onto the surface of the calcium salt, wherein the silica is not incorporated into the structure of the calcium salt, and wherein the composition is bioactive.