Patents Assigned to Novactyl, Inc.
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Patent number: 6939884Abstract: Compositions are provided, which comprise at least one nucleoside analogue inhibitor, pharmaceutically acceptable salts, solvates, or prodrugs thereof and fusaric acid, derivatives, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising the above compositions are also provided that optionally further include another therapeutically effective compound, such as a carrier. Systemic and topical preparations comprising the above compositions are also provided as well as methods of treating viral diseases by the administration of the above antiviral agents to a patient.Type: GrantFiled: December 3, 2002Date of Patent: September 6, 2005Assignee: Novactyl, Inc.Inventors: Michael G. Douglas, Avinash N. Amin
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Patent number: 6743771Abstract: Compositions and methods for controlling prepathological and pathological protein assembly or aggregation using picolinic acid, analogs, or derivatives thereof are described. The compositions of the invention, capable of solubilizing a conformationally altered protein, comprise a carboxylic acid anion of picolinic acid, its analogs, or derivatives thereof and a cation. According to the methods of the invention, conformationally altered protein assembly or aggregation in an animal is prevented or reversed by introducing the compositions of the invention to the conformationally altered protein. The compositions can be administered systemically by injection, oral administration, inhalation, transdermal, or other routes of administration.Type: GrantFiled: July 12, 2001Date of Patent: June 1, 2004Assignee: Novactyl, Inc.Inventors: Michael G. Douglas, Avinash N. Amin
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Patent number: 6579891Abstract: An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes and enzymes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory, analgesic antiangiogenic and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn, inflammatory responses, untoward angiogenesis and other diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS.Type: GrantFiled: September 8, 2000Date of Patent: June 17, 2003Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol
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Patent number: 6569864Abstract: Compositions and kits comprising acyclovir and fusaric acid are provided.Type: GrantFiled: July 11, 2001Date of Patent: May 27, 2003Assignee: Novactyl, Inc.Inventors: Michael G. Douglas, Avinash N. Amin
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Patent number: 6441009Abstract: An agent and method for the prevention and treatment of toxicity caused by heavy metals such as depleted uranium, tungsten and nickel and metals such as iron, lead and copper. The agent is a chelating agent such as picolinic acid or derivatives thereof. The agent chelates and inactivates the metals which can be carcinogenic or poisonous. The agent can be administered to chelate excessive copper as a result of Wilson's disease. The agent can be administered orally or by other systemic routes such as injections and the like.Type: GrantFiled: October 2, 2000Date of Patent: August 27, 2002Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol
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Patent number: 6410570Abstract: An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.Type: GrantFiled: September 8, 2000Date of Patent: June 25, 2002Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol
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Patent number: 6407125Abstract: A biological response modifying metal ion chelating agent such as picolinic acid, analogs or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes and enzymes required for growth, replication or inflammatory response. The preparations can be administered systemically or topically. The products can be used to reduce systemic levels of metals in disease states such as Wilson's disease, iron or lead toxicity. The preparations have antineoplastic, antiviral, antiinflammatory, analgesic antiangiogenic, antiproliferative as well as hematopoetic and immune stimulant, effects and are used in the treatment of warts, psoriasis, acne, cancers, sunburn, inflammatory responses, untoward angiogenesis, immune depression and other diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS.Type: GrantFiled: October 2, 2000Date of Patent: June 18, 2002Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol
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Patent number: 6403618Abstract: A metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes and enzymes required for growth and replication of blood vessel cells. The preparations can be administered systemically or for topical use. The preparations have antineoplastic activity augmented by the antiangiogenic properties.Type: GrantFiled: October 2, 2000Date of Patent: June 11, 2002Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol
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Patent number: 6127393Abstract: An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.Type: GrantFiled: August 1, 1998Date of Patent: October 3, 2000Assignee: Novactyl, Inc.Inventor: Jose A. Fernandez-Pol