Abstract: Antibodies that specifically bind to the human tight junction molecule CLDN18.2 and have functional properties that make them suitable for use in antibody-based immunotherapies of a disease associated with aberrant expression of CLDN18.2 are disclosed.
Type:
Grant
Filed:
February 3, 2020
Date of Patent:
August 9, 2022
Assignee:
NovaRock Biotherapeutics, Ltd.
Inventors:
Han Li, Ming Lei, Yi Pei, Haichun Huang
Abstract: The present disclosure provides antibodies and antibody fragments thereof that bind to IL-23p19. The disclosed antibodies and antibody fragments thereof can modulate a biological activity of the IL-23 receptor signaling axis and are therefore useful for the treatment of immune-mediated inflammatory disorders.
Type:
Grant
Filed:
November 13, 2020
Date of Patent:
July 26, 2022
Assignee:
NOVAROCK BIOTHERAPEUTICS, LTD.
Inventors:
Haichun Huang, Ming Lei, Yi Pei, Han Li