Patents Assigned to Novartis AC
  • Mutant forms of meningococcal ADP-ribosylating toxin
    Patent number: 7858096
    Abstract: NMB1343 is an ADP-ribosylating toxin from Neisseria meningitidis. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s) is/are preferably Glu to Asp. The protein of the invention preferably has reduced or eliminated ADP-ribosyltransferase and/or NAD-glycohydrolase activity relative to the wild-type protein.
    Type: Grant
    Filed: September 1, 2003
    Date of Patent: December 28, 2010
    Assignee: Novartis AC
    Inventors: Mariagrazia Pizza, Vega Masignani
  • Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
    Patent number: 6833367
    Abstract: The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: December 21, 2004
    Assignee: Novartis AC
    Inventors: Frederick R. Kinder, Jr., Kenneth W. Bair, Timothy M. Ramsey, Michael L. Sabio