Patents Assigned to Novartis Corporation
  • Patent number: 5783704
    Abstract: Compounds of formu (I) wherein n and Z are as defined in claim 1, and, where appropriate, tautomers thereof, in each case in free form, or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: July 21, 1998
    Assignee: Novartis Corporation
    Inventors: Henry Szczepanski, Haukur Kristinsson, Peter Maienfisch, Josef Ehrenfreund
  • Patent number: 5783715
    Abstract: The invention relates to ferrocenyldiphosphine ligands containing a silylene group, ferrocenyldiphosphines bound to inorganic or polymeric organic supports by this silylene group, their preparation and also their metal complexes with transition metals such as rhodium or iridium. The invention also relates to the use of these complexes for hydrogenating organic double or triple bonds, in particular olefinic double bonds and carbon-heteroatom double bonds. The complexes are particularly suitable for enantioselective hydrogenation using chiral diphosphines and prochiral unsaturated compounds.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: July 21, 1998
    Assignee: Novartis Corporation
    Inventor: Benoit Pugin
  • Patent number: 5780500
    Abstract: Base-substituted debenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: July 14, 1998
    Assignee: Novartis Corporation
    Inventors: Claudia Betschart, Kaspar Zimmermann
  • Patent number: 5780501
    Abstract: Base-substituted dibenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: July 14, 1998
    Assignee: Novartis Corporation
    Inventors: Claudia Betschart, Kaspar Zimmermann
  • Patent number: 5777062
    Abstract: The invention relates to polymers having structural repeating units of at least one monomer MM which contains a hydroxyl group or a primary or secondary amine group as a functional group bonded directly or in a side chain, wherein the functional group is bonded via a bridge group Q formed by a diisocyanate to the hydroxyl group or primary or secondary amino group of an aliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic ditertiary diphosphine, the phosphine groups of which are bonded to a carbon chain in the 1,2-, 1,3-, 1,4- or 1,5-position relative to one another. The invention also relates to a process for their preparation and to rhodium and iridium complexes with these diphosphine ligands.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: July 7, 1998
    Assignee: Novartis Corporation
    Inventor: Benoit Pugin
  • Patent number: 5776981
    Abstract: A method of systemically controlling endoparasites and ectoparasites of warm-blooded animals by orally or percutaneously administering to the animal a parasiticidally effective amount of an acyl urea compound.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: July 7, 1998
    Assignee: Novartis Corporation
    Inventors: Michael Fred Potter, George Lorton Rotramel, Andrew James Caruso, David Teh-Wei Chou, Paul Alfred Cain
  • Patent number: 5776982
    Abstract: A method of systemically controlling endoparasites and ectoparasites of warm-blooded animals by orally or percutaneously administering to the animal a parasiticidally effective amount of an acyl urea compound.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 7, 1998
    Assignee: Novartis Corporation
    Inventors: Michael Fred Potter, George Lorton Rotramel, Andrew James Caruso, David Teh-Wei Chou, Paul Alfred Cain
  • Patent number: 5773030
    Abstract: Internally cross-linked albumin microspheres their surface being modified by attachment of polyoxy(C.sub.-)alkylene chains having a terminal ether group, especially such containing pharmacologically active agents, usable for pharmaceutical compositions.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: June 30, 1998
    Assignee: Novartis Corporation
    Inventors: Rudolf Nastke, Ernst Neuenschwander, Andreas Leonhardt
  • Patent number: 5770696
    Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. "The auxiliary proteins enhance the insecticidal activity of pesticidal proteins." Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 23, 1998
    Assignee: Novartis Corporation
    Inventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Gordon J. Nye, Brian Carr, Nalini M. Desai, Kristy Kostichka, Nicholas B. Duck, Juan J. Estruch
  • Patent number: 5770758
    Abstract: Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0,1,2 or 3;Z is CN, CO-A or CS-A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R .sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 23, 1998
    Assignee: Novartis Corporation
    Inventors: Walter Kunz, Beat Jau
  • Patent number: 5766900
    Abstract: Methods of regenerating fertile Zea mays plants from protoplasts or protoplast-derived cells are described. The protoplasts or cells may be derived from embryogenic cell cultures or callus cultures. The protoplasts, cells and resulting plants may be transgenic, containing, for example, chimeric genes coding for a polypeptide having substantially the insect toxicity properties of the crystal protein produced by Bacillus thuringiensis.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: June 16, 1998
    Assignee: Novartis Corporation
    Inventors: Ray Shillito, Gleta Carswell, Christian Harms, Yin-Fu Chang
  • Patent number: 5758766
    Abstract: The invention provides a package for accommodating product having at least two components, which package has at least two self-contained chambers in which the individual components of the product can be stored in such a manner that they are hermetically separated from one another. The end regions of the chamber walls are in the form of a common closure for the individual chambers such the individual chambers can only be opened simultaneously.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: June 2, 1998
    Assignee: Novartis Corporation
    Inventors: Hans-Uwe Richter, Marcel Aeby, Willy Baettig, Karl Meyer
  • Patent number: 5759561
    Abstract: A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behaviour of the pests and b) at least one pesticidally active compound, wherein the biologically active components are contained in a flowable or viscous non-hardening matrix that is resistant to water and weather, is protected against light and is suitable for distribution in the form of droplets or droplet-like units or spots that adhere to a substrate, by means of which matrix the behaviour-modifying substance is protected against UV radiation and from which it is slowly released in a biologically effective amount over a prolonged period, and wherein the pesticidally active compound can be taken up in a pesticidally effective amount from the surface of the droplets or droplet-like units or spots by the pests to be controlled; as well as a method of controlling the said pests, especially plant-destructive insects.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 2, 1998
    Assignee: Novartis Corporation
    Inventors: Max Angst, Fran.cedilla.ois Gugumus, Gunther Rist, Manfred Vogt, Jean Rody
  • Patent number: 5759565
    Abstract: Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.
    Type: Grant
    Filed: December 31, 1991
    Date of Patent: June 2, 1998
    Assignee: Novartis Corporation
    Inventors: Moise Azria, Thomas Cavanak
  • Patent number: 5756450
    Abstract: A combination of a pharmacologically active compound and a water soluble monoester of a saturated or unsaturated (C.sub.6-18) fatty acid and a polyol, especially a saccharide, particularly as a solid solution of the active compound in the monoester.The solid solution is especially suitable for substantially water insoluble active compounds, particularly such polypeptides, e.g. ciclosporins and is in all desirable weight ratios miscible with water.The invention also, in particular, provides pharmaceutical compositions comprising a cyclosporin as active ingredient together with a fatty acid saccharide monoester.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Lorenz Hahn, Birgit Hauer, Ulrich Posanski
  • Patent number: 5756338
    Abstract: The present invention concerns a novel DNA sequence coding for an Aspergillus aspartic protease, an Aspergillus aspartic protease per se and a method for the preparation thereof. The invention further concerns a novel Aspergillus mutant strain defective in a protease of the aspartic proteinase-type, which is useful for the expression of heterologous protein, and a method for the preparation of such a mutant strain.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Frank Buxton, Gabor Jarai, Jacob Visser
  • Patent number: 5756426
    Abstract: Described herein are compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom andY is OR.sub.11 or N(R.sub.12)R.sub.13, orb) X is CH andY is OR.sub.11,and in which furthermore:R.sub.11 is C.sub.1 -C.sub.4 alkyl;R.sub.12 and R.sub.13, independently, are hydrogen or C.sub.1 -C.sub.4 alkyl;A is an O atom or the group NR.sub.4 ; and whereinR.sub.1, R.sub.2 and R.sub.3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Hugo Ziegler, Stephan Trah, Saleem Farooq, Rene Zurfluh
  • Patent number: 5757014
    Abstract: In the optical detection device (1), the excitation light guide (11) and the emission light guide (12) form a structural unit having the end face (14) facing the fluorescence changer (4). The end face (14) physically corresponds substantially to one of the boundary surfaces of the two light guides (11, 12). As a result, the detection device (1) can be separated in a simple manner into an optical part and a mechanical part which are in optical contact only by way of the end face (14). All of the elements in the optical light path are connected in a mechanically stable manner by means of the index-matching medium 20, as a result of which the light between the light source (10) and the photoelectric sensor (13) propagates only in media having a comparable refractive index. The light source (10) is preferably a light-emitting diode.
    Type: Grant
    Filed: April 1, 1996
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Alfredo Emilio Bruno, Steven Mark Barnard, Marizel Rouilly
  • Patent number: 5756811
    Abstract: There is described a process for the preparation of a compound of formula I ##STR1## in which process: a) a compound of formula II ##STR2## is reacted with an organolithium compound of formula IIILi--R.sub.7 (III)b) the resulting lithium complex is reacted with a compound of formula IVY.sub.1 --CO--CO--Y.sub.1 IVto form a compound of formula V ##STR3## c) that compound is, in either order, c1) oximated with O-methylhydroxylamine; or oximated with hydroxylamine and then methylated or fluoromethylated or difluoromethylated;c2) reacted with a chloroformic acid ester.X, m, Y, R.sub.1 to R.sub.3 and R.sub.7 are as defined in the description.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Jean-Marie Assercq, Hans-Dieter Schneider, Albert Pfiffner, Werner Pfaff
  • Patent number: 5753618
    Abstract: The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better tolerated when administered by injection.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 19, 1998
    Assignee: Novartis Corporation
    Inventors: Thomas Cavanak, Alan Harris